Development and evaluation of a manual segmentation protocol for deep grey matter in multiple sclerosis: Towards accelerated semi-automated references
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Background: Deep grey matter (dGM) structures, particularly the thalamus, are clinically relevant in multiple sclerosis (MS). However, segmentation of dGM in MS is challenging; labeled MS-specific reference sets are needed for objective evaluation and training of new methods. Objectives: This study aimed to (i) create a standardized protocol for manual delineations of dGM; (ii) evaluate the reliability of the protocol with multiple raters; and (iii) evaluate the accuracy of a fast-semi-automated segmentation approach (FASTSURF). Methods: A standardized manual segmentation protocol for caudate nucleus, putamen, and thalamus was created, and applied by three raters on multi-center 3D T1-weighted MRI scans of 23 MS patients and 12 controls. Intra- and inter-rater agreement was assessed through intra-class correlation coefficient (ICC); spatial overlap through Jaccard Index (JI) and generalized conformity index (CIgen). From sparse delineations, FASTSURF reconstructed full segmentations; accuracy was assessed both volumetrically and spatially. Results: All structures showed excellent agreement on expert manual outlines: intra-rater JI > 0.83; inter-rater ICC ≥ 0.76 and CIgen ≥ 0.74. FASTSURF reproduced manual references excellently, with ICC ≥ 0.97 and JI ≥ 0.92. Conclusions: The manual dGM segmentation protocol showed excellent reproducibility within and between raters. Moreover, combined with FASTSURF a reliable reference set of dGM segmentations can be produced with lower workload.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 102659 |
| Tidsskrift | NeuroImage: Clinical |
| Vol/bind | 30 |
| ISSN | 2213-1582 |
| DOI | |
| Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
The members of the MAGNIMS Study Group Steering Committee are: F. Barkhof and H. Vrenken (Amsterdam UMC, location VUmc, Amsterdam, Netherlands), O. Ciccarelli and T. Yousry (Queen Square MS Centre, UCL Institute of Neurology, London, UK), N. De Stefano (University of Siena, Siena, Italy), C. Enzinger (Department of Neurology, Medical University of Graz, Graz, Austria), M. Filippi and M.A. Rocca (San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy), C. Gasperini (San Camillo-Forlanini Hospital, Rome, Italy), L. Kappos (University of Basel, Basel, Switzerland), J. Palace (University of Oxford Hospitals Trust, Oxford, UK), A. Rovira and J. Sastre-Garriga (Hospital Universitari Vall d'Hebron, Universitat Aut?noma de Barcelona, Barcelona, Spain). The study was funded by the Nauta fonds through a travel grant. The MS Center Amsterdam is supported by the Dutch MS Research Foundation through a program grant (current grant 18-358f). D.B. is supported by project PI18/00823 from the ?Fondo de Investigaci?n Sanitaria Carlos III?. F.B. is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. The acquisition of data in London was funded by supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.
Funding Information:
The members of the MAGNIMS Study Group Steering Committee are: F. Barkhof and H. Vrenken (Amsterdam UMC, location VUmc, Amsterdam, Netherlands), O. Ciccarelli and T. Yousry (Queen Square MS Centre, UCL Institute of Neurology, London, UK), N. De Stefano (University of Siena, Siena, Italy), C. Enzinger (Department of Neurology, Medical University of Graz, Graz, Austria), M. Filippi and M.A. Rocca (San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy), C. Gasperini (San Camillo-Forlanini Hospital, Rome, Italy), L. Kappos (University of Basel, Basel, Switzerland), J. Palace (University of Oxford Hospitals Trust, Oxford, UK), A. Rovira and J. Sastre-Garriga (Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain). The study was funded by the Nauta fonds through a travel grant. The MS Center Amsterdam is supported by the Dutch MS Research Foundation through a program grant (current grant 18-358f). D.B. is supported by project PI18/00823 from the “Fondo de Investigación Sanitaria Carlos III”. F.B. is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. The acquisition of data in London was funded by supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.
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© 2021 The Authors
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