Cumulative Lactation and Clinical Metabolic Outcomes at Mid-Life among Women with a History of Gestational Diabetes

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Cumulative Lactation and Clinical Metabolic Outcomes at Mid-Life among Women with a History of Gestational Diabetes. / Wander, Pandora L.; Hinkle, Stefanie N.; Enquobahrie, Daniel A.; Wu, Jing; Ley, Sylvia H.; Grunnet, Louise G.; Chavarro, Jorge E.; Li, Mengying; Bjerregaard, Anne A.; Liu, Aiyi; Damm, Peter; Sherman, Seth; Rawal, Shristi; Zhu, Yeyi; Chen, Liwei; Mills, James L.; Hu, Frank B.; Vaag, Allan; Olsen, Sjurdur F.; Zhang, Cuilin.

I: Nutrients, Bind 14, Nr. 3, 650, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wander, PL, Hinkle, SN, Enquobahrie, DA, Wu, J, Ley, SH, Grunnet, LG, Chavarro, JE, Li, M, Bjerregaard, AA, Liu, A, Damm, P, Sherman, S, Rawal, S, Zhu, Y, Chen, L, Mills, JL, Hu, FB, Vaag, A, Olsen, SF & Zhang, C 2022, 'Cumulative Lactation and Clinical Metabolic Outcomes at Mid-Life among Women with a History of Gestational Diabetes', Nutrients, bind 14, nr. 3, 650. https://doi.org/10.3390/nu14030650

APA

Wander, P. L., Hinkle, S. N., Enquobahrie, D. A., Wu, J., Ley, S. H., Grunnet, L. G., Chavarro, J. E., Li, M., Bjerregaard, A. A., Liu, A., Damm, P., Sherman, S., Rawal, S., Zhu, Y., Chen, L., Mills, J. L., Hu, F. B., Vaag, A., Olsen, S. F., & Zhang, C. (2022). Cumulative Lactation and Clinical Metabolic Outcomes at Mid-Life among Women with a History of Gestational Diabetes. Nutrients, 14(3), [650]. https://doi.org/10.3390/nu14030650

Vancouver

Wander PL, Hinkle SN, Enquobahrie DA, Wu J, Ley SH, Grunnet LG o.a. Cumulative Lactation and Clinical Metabolic Outcomes at Mid-Life among Women with a History of Gestational Diabetes. Nutrients. 2022;14(3). 650. https://doi.org/10.3390/nu14030650

Author

Wander, Pandora L. ; Hinkle, Stefanie N. ; Enquobahrie, Daniel A. ; Wu, Jing ; Ley, Sylvia H. ; Grunnet, Louise G. ; Chavarro, Jorge E. ; Li, Mengying ; Bjerregaard, Anne A. ; Liu, Aiyi ; Damm, Peter ; Sherman, Seth ; Rawal, Shristi ; Zhu, Yeyi ; Chen, Liwei ; Mills, James L. ; Hu, Frank B. ; Vaag, Allan ; Olsen, Sjurdur F. ; Zhang, Cuilin. / Cumulative Lactation and Clinical Metabolic Outcomes at Mid-Life among Women with a History of Gestational Diabetes. I: Nutrients. 2022 ; Bind 14, Nr. 3.

Bibtex

@article{8cf1b767dc5a470dbc3e0e1ebee2bc1f,

title = "Cumulative Lactation and Clinical Metabolic Outcomes at Mid-Life among Women with a History of Gestational Diabetes",

abstract = "Lactation is associated with a lower risk of subsequent cardiometabolic disease among parous women; however, the underlying mechanisms are unknown. Further, the potential protective effects of lactation on cardiometabolic risk markers at mid-life among high-risk women with past gestational diabetes (GDM) are not established. Using data from the Diabetes & Women{\textquoteright}s Health Study (2012-2014; n = 577), a longitudinal cohort of women with past GDM from the Danish National Birth Cohort (1996-2002), we assessed associations of cumulative lactation duration (none, < 6 months, 6-12 months, ≥ 12-24 months, and ≥ 24 months) with clinical metabolic outcomes (including type 2 diabetes [T2D], prediabetes, and obesity) and cardiometabolic biomarkers (including biomarkers of glucose/insulin metabolism, fasting lipids, inflammation, and anthropometrics) 9-16 years after enrollment when women were at mid-life. At follow-up, women were 43.9 years old (SD 4.6) with a BMI of 28.7 kg/m2 (IQR 24.6, 33.0); 28.6% of participants had T2D, 39.7% had prediabetes, and 41.2% had obesity. Relative risks (95% CI) of T2D for 0-6, 6-12, 12-24, and ≥ 24 months of cumulative lactation duration compared to none were 0.94 (0.62,1.44), 0.88 (0.59,1.32), 0.73 (0.46,1.17), and 0.71 (0.40,1.27), respectively. Cumulative lactation duration was not significantly associated with any other clinical outcome or continuous biomarker. In this high-risk cohort of middle-aged women with past GDM, T2D, prediabetes, and obesity were common at follow-up, but not associated with history of cumulative lactation duration 9-16 years after the index pregnancy. Further studies in diverse populations among women at mid-age are needed to understand associations of breastfeeding with T2D.",

keywords = "Biomarkers, Breastfeeding, Diabetes, Lactation, Obesity, Pregnancy, Women",

author = "Wander, {Pandora L.} and Hinkle, {Stefanie N.} and Enquobahrie, {Daniel A.} and Jing Wu and Ley, {Sylvia H.} and Grunnet, {Louise G.} and Chavarro, {Jorge E.} and Mengying Li and Bjerregaard, {Anne A.} and Aiyi Liu and Peter Damm and Seth Sherman and Shristi Rawal and Yeyi Zhu and Liwei Chen and Mills, {James L.} and Hu, {Frank B.} and Allan Vaag and Olsen, {Sjurdur F.} and Cuilin Zhang",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

doi = "10.3390/nu14030650",

language = "English",

volume = "14",

journal = "Nutrients",

issn = "2072-6643",

publisher = "M D P I AG",

number = "3",

}

RIS

TY - JOUR

T1 - Cumulative Lactation and Clinical Metabolic Outcomes at Mid-Life among Women with a History of Gestational Diabetes

AU - Wander, Pandora L.

AU - Hinkle, Stefanie N.

AU - Enquobahrie, Daniel A.

AU - Wu, Jing

AU - Ley, Sylvia H.

AU - Grunnet, Louise G.

AU - Chavarro, Jorge E.

AU - Li, Mengying

AU - Bjerregaard, Anne A.

AU - Liu, Aiyi

AU - Damm, Peter

AU - Sherman, Seth

AU - Rawal, Shristi

AU - Zhu, Yeyi

AU - Chen, Liwei

AU - Mills, James L.

AU - Hu, Frank B.

AU - Vaag, Allan

AU - Olsen, Sjurdur F.

AU - Zhang, Cuilin

PY - 2022

Y1 - 2022

N2 - Lactation is associated with a lower risk of subsequent cardiometabolic disease among parous women; however, the underlying mechanisms are unknown. Further, the potential protective effects of lactation on cardiometabolic risk markers at mid-life among high-risk women with past gestational diabetes (GDM) are not established. Using data from the Diabetes & Women’s Health Study (2012-2014; n = 577), a longitudinal cohort of women with past GDM from the Danish National Birth Cohort (1996-2002), we assessed associations of cumulative lactation duration (none, < 6 months, 6-12 months, ≥ 12-24 months, and ≥ 24 months) with clinical metabolic outcomes (including type 2 diabetes [T2D], prediabetes, and obesity) and cardiometabolic biomarkers (including biomarkers of glucose/insulin metabolism, fasting lipids, inflammation, and anthropometrics) 9-16 years after enrollment when women were at mid-life. At follow-up, women were 43.9 years old (SD 4.6) with a BMI of 28.7 kg/m2 (IQR 24.6, 33.0); 28.6% of participants had T2D, 39.7% had prediabetes, and 41.2% had obesity. Relative risks (95% CI) of T2D for 0-6, 6-12, 12-24, and ≥ 24 months of cumulative lactation duration compared to none were 0.94 (0.62,1.44), 0.88 (0.59,1.32), 0.73 (0.46,1.17), and 0.71 (0.40,1.27), respectively. Cumulative lactation duration was not significantly associated with any other clinical outcome or continuous biomarker. In this high-risk cohort of middle-aged women with past GDM, T2D, prediabetes, and obesity were common at follow-up, but not associated with history of cumulative lactation duration 9-16 years after the index pregnancy. Further studies in diverse populations among women at mid-age are needed to understand associations of breastfeeding with T2D.

AB - Lactation is associated with a lower risk of subsequent cardiometabolic disease among parous women; however, the underlying mechanisms are unknown. Further, the potential protective effects of lactation on cardiometabolic risk markers at mid-life among high-risk women with past gestational diabetes (GDM) are not established. Using data from the Diabetes & Women’s Health Study (2012-2014; n = 577), a longitudinal cohort of women with past GDM from the Danish National Birth Cohort (1996-2002), we assessed associations of cumulative lactation duration (none, < 6 months, 6-12 months, ≥ 12-24 months, and ≥ 24 months) with clinical metabolic outcomes (including type 2 diabetes [T2D], prediabetes, and obesity) and cardiometabolic biomarkers (including biomarkers of glucose/insulin metabolism, fasting lipids, inflammation, and anthropometrics) 9-16 years after enrollment when women were at mid-life. At follow-up, women were 43.9 years old (SD 4.6) with a BMI of 28.7 kg/m2 (IQR 24.6, 33.0); 28.6% of participants had T2D, 39.7% had prediabetes, and 41.2% had obesity. Relative risks (95% CI) of T2D for 0-6, 6-12, 12-24, and ≥ 24 months of cumulative lactation duration compared to none were 0.94 (0.62,1.44), 0.88 (0.59,1.32), 0.73 (0.46,1.17), and 0.71 (0.40,1.27), respectively. Cumulative lactation duration was not significantly associated with any other clinical outcome or continuous biomarker. In this high-risk cohort of middle-aged women with past GDM, T2D, prediabetes, and obesity were common at follow-up, but not associated with history of cumulative lactation duration 9-16 years after the index pregnancy. Further studies in diverse populations among women at mid-age are needed to understand associations of breastfeeding with T2D.

KW - Biomarkers

KW - Breastfeeding

KW - Diabetes

KW - Lactation

KW - Obesity

KW - Pregnancy

KW - Women

U2 - 10.3390/nu14030650

DO - 10.3390/nu14030650

M3 - Journal article

C2 - 35277008

AN - SCOPUS:85124390592

VL - 14

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 3

M1 - 650

ER -

ID: 306439467