Correlation between asparaginase enzyme activity levels and coagulation parameters during childhood acute lymphoblastic leukemia treatment
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Thromboembolism is a serious toxicity in the treatment of acute lymphoblastic leukemia (ALL), but little is known about the correlation between asparaginase enzyme activity (ASA) levels and coagulation parameters. We included 65 non-high risk ALL patients, aged 1-17 years. Coagulation parameters and corresponding ASA levels were measured during asparaginase treatment. We found ASA to be negatively correlated with antithrombin and fibrinogen up to ASA levels of 250 IU/L, after which these parameters reached a plateau and did not decrease further with further increase of ASA. Patients with silent inactivation of asparaginase had normal coagulation parameters.
Originalsprog | Engelsk |
---|---|
Artikelnummer | e30085 |
Bogserie | Medical and Pediatric Oncology. Supplement |
Vol/bind | 70 |
Udgave nummer | 2 |
Antal sider | 5 |
ISSN | 1545-5009 |
DOI | |
Status | Udgivet - 2023 |
ID: 327278800