Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, finding that individuals with ASD and individuals with ADHD had a similar burden of rare protein-truncating variants in evolutionarily constrained genes, both significantly higher than controls. This motivated a combined analysis across ASD and ADHD, identifying microtubule-associated protein 1A (MAP1A) as a new exome-wide significant gene conferring risk for childhood psychiatric disorders.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Nature Neuroscience |
Vol/bind | 22 |
Udgave nummer | 12 |
Sider (fra-til) | 1961-1965 |
ISSN | 1097-6256 |
DOI | |
Status | Udgivet - 2019 |
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884695/pdf/nihms-1540803.pdf
Accepteret manuskript
ID: 231901715