Ancient mitogenomics
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Ancient mitogenomics. / Ho, Simon Y. W.; Gilbert, Tom.
I: Mitochondrion, Bind 10, Nr. 1, 01.2010, s. 1-11.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Ancient mitogenomics
AU - Ho, Simon Y. W.
AU - Gilbert, Tom
PY - 2010/1
Y1 - 2010/1
N2 - The mitochondrial genome has been the traditional focus of most research into ancient DNA, owing to its high copy number and population-level variability. Despite this long-standing interest in mitochondrial DNA, it was only in 2001 that the first complete ancient mitogenomic sequences were obtained. As a result of various methodological developments, including the introduction of high-throughput sequencing techniques, the total number of ancient mitogenome sequences has increased rapidly over the past few years. In this review, we present a brief history of ancient mitogenomics and describe the technical challenges that face researchers in the field. We catalogue the diverse sequencing methods and source materials used to obtain ancient mitogenomic sequences, summarise the associated genetic and phylogenetic studies that have been conducted, and evaluate the future prospects of the field.
AB - The mitochondrial genome has been the traditional focus of most research into ancient DNA, owing to its high copy number and population-level variability. Despite this long-standing interest in mitochondrial DNA, it was only in 2001 that the first complete ancient mitogenomic sequences were obtained. As a result of various methodological developments, including the introduction of high-throughput sequencing techniques, the total number of ancient mitogenome sequences has increased rapidly over the past few years. In this review, we present a brief history of ancient mitogenomics and describe the technical challenges that face researchers in the field. We catalogue the diverse sequencing methods and source materials used to obtain ancient mitogenomic sequences, summarise the associated genetic and phylogenetic studies that have been conducted, and evaluate the future prospects of the field.
KW - Animals
KW - DNA, Mitochondrial
KW - Fossils
KW - Genomics
KW - Humans
KW - Phylogeny
KW - Polymerase Chain Reaction
KW - Sequence Analysis, DNA
U2 - 10.1016/j.mito.2009.09.005
DO - 10.1016/j.mito.2009.09.005
M3 - Review
C2 - 19788938
VL - 10
SP - 1
EP - 11
JO - Mitochondrion
JF - Mitochondrion
SN - 1567-7249
IS - 1
ER -
ID: 32220807