Ancient mitogenomics

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

The mitochondrial genome has been the traditional focus of most research into ancient DNA, owing to its high copy number and population-level variability. Despite this long-standing interest in mitochondrial DNA, it was only in 2001 that the first complete ancient mitogenomic sequences were obtained. As a result of various methodological developments, including the introduction of high-throughput sequencing techniques, the total number of ancient mitogenome sequences has increased rapidly over the past few years. In this review, we present a brief history of ancient mitogenomics and describe the technical challenges that face researchers in the field. We catalogue the diverse sequencing methods and source materials used to obtain ancient mitogenomic sequences, summarise the associated genetic and phylogenetic studies that have been conducted, and evaluate the future prospects of the field.
OriginalsprogEngelsk
TidsskriftMitochondrion
Vol/bind10
Udgave nummer1
Sider (fra-til)1-11
Antal sider11
ISSN1567-7249
DOI
StatusUdgivet - jan. 2010

ID: 32220807