Søren Brøgger Christensen
Professor emeritus
Medicinal Chemistry
Jagtvej 162, 2100 København Ã
Medlem af:
Author or coauthor more than 185 articles or bookchapters in scientific journals or books, coeditor on 2 books and coinventor on 8 patents, h-index 50.
The main topic of research has been isolation of natural products with biological activities and optimizing of their structures to develop new drugs. The focus points have been development of mipsagargin from thapsigargin for treatment of cancer diseases and development of malaria drugs from licochalcone A.
Udvalgte publikationer
- Udgivet
Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells
Griend, D. J. V., Antony, L., Dalrymple, S. L., Xu, Y., Christensen, Søren Brøgger, Denmeade, S. R. & Isaacs, J. T., 2009, I: Molecular Cancer Therapeutics. 8, 5, s. 1340-1349Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase
Paulsen, E. S., Villadsen, J., Tenori, E., Liu, H., Bonde, D. F., Lie, M. A., Bublitz, M., Olesen, C. L., Autzen, Henriette Elisabeth, Dach, I., Sehgal, P., Nissen, P., Møller, J., Schiøtt, B. & Christensen, Søren Brøgger, 9 maj 2013, I: Journal of Medicinal Chemistry. 56, 9, s. 3609-19 11 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
ID: 1300951
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1553
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The antiparasitic compound Licochalcon A is a potent echinocytogenic agent that modifies erythrocyte membrane in the concentration region where the antiplasmodial activity is observed
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Udgivet -
318
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Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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292
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Demethoxycurcumin is a potent inhibitor of P-type ATPases from diverse kingdoms of life
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Udgivet