Nicolai Jacob Wewer Albrechtsen

Nicolai Jacob Wewer Albrechtsen

Gæsteforsker

I have two major focus areas in my research and clinical work.

The first focus on the pathophysiology of metabolic diseases such as liver diseases. I am in particular interested in how our gastrointestinal tract regulates metabolism and how impaired inter-organ communication (the liver-alpha cell axis) contribute to development of comorbidities such as diabetes. To capture these dysmetabolic conditions I have developed and evaluate biochemical based measurement technologies that have enabled my research group to pinpoint disturbances and common pathways in diabetes and fatty liver disease.

 

The second focus on using state of the art mass-spectrometry based proteomics to study human disease and to explore the clinical applicability of such technology. I am currently the team leader of a visionary effort that bridges forefront technology from NNF Center of Protein Research to Denmark most specialized hospital, Rigshospitalet. Here, we together with several departments and clinicians utilizes this advanced technology to evaluate its clinical potential application for diagnostic, prognostics and disease monitoring.

Udvalgte publikationer

  1. Udgivet

    The liver-alpha cell axis and type 2 diabetes

    Albrechtsen, Nicolai Jacob Wewer, Pedersen, J., Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Suppli, M. P., Janah, L., Gromada, J., Vilstrup, H., Knop, Filip Krag & Holst, Jens Juul, 2019, I: Endocrine Reviews. 40, 5, s. 1353-1366

    Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

  2. Udgivet
  3. Udgivet

    Methods and Guidelines for Measurement of Glucagon in Plasma

    Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2019, I: International Journal of Molecular Sciences (Online). 20, 10 s., 5416.

    Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

  4. Udgivet

    Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

    Albrechtsen, Nicolai Jacob Wewer, Geyer, P. E., Doll, S., Treit, P. V., Bojsen-Møller, K. N., Martinussen, C., Jørgensen, N. B., Torekov, Signe Sørensen, Meier, F., Niu, Lili, Santos Delgado, Alberto, Keilhauer, E. C., Holst, Jens Juul, Madsbad, Sten & Mann, Matthias, 2018, I: Cell Systems. 7, 6, s. 601-612

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  5. Udgivet

    Proteomics reveals the effects of sustained weight loss on the human plasma proteome

    Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Tyanova, S., Grassl, N., Lehmann, Eva Winning, Lundgren, Julie Rehné, Madsbad, Sten, Holst, Jens Juul, Torekov, Signe Sørensen & Mann, Matthias, 22 dec. 2016, I: Molecular Systems Biology. 12, 16 s., 901.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  6. Udgivet

    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes

    Batista, T. M., Jayavelu, A. K., Albrechtsen, Nicolai Jacob Wewer, Iovino, S., Lebastchi, J., Pan, H., Dreyfuss, J. M., Krook, A., Zierath, Juleen R, Mann, Matthias & Kahn, C. R., 2020, I: Cell Metabolism. 32, 5, s. 844-859.e5

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

ID: 95638859