Moustapha Saad El-Deen Kassem
Morphogenesis and Differentiation Program
2200 København N.
The main research focus is studying mechanisms of impaired bone formation and bone fragility during aging and in osteoporosis as well as molecular mechanisms of osteoblast (bone forming cells) differentiation of human skeletal (mesenchymal) stem cells (MSC); studying the phenomenon of biological aging of MSC with respect to lineage fate determination and how the cellular senescent phenotype can be overcome by genetic and non-genetic approaches. I have been combining clinical studies with cellular and molecular studies and employing state-of-the-art technologies of genetics and proteomics in molecular phenotyping of patients’ cohorts. I am studying the possible clinical use of MSC in tissue regeneration in a variety of diseases including fracture healing.