Moustapha Saad El-Deen Kassem

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CURRICULUM VITAE
PERSONAL DATA:
Name: Moustapha Kassem

DEGREES AND LICENSE EXAMS:
November 1983 MBBCh., Kasr-Al-Aini Medical School, University of Cairo, Egypt.
March 1985 Egyptian medical license.
January 1988 Danish medical license.
July 1993 License to practice medicine in USA and UK
August 1994 PhD in Medicine, University of Aarhus, Aarhus, Denmark
November 1997 Doctorate of Science (DSc), University of Aarhus, Aarhus, Denmark.

AWARDS:
1995 The young investigator award, American Society for Bone and Mineral Research
1996 Award for best research project, the Danish Society of Internal Medicine
2003 Generalkonsul Ernst Carlsens foundation award
2004 Research prize from the Danish Free Masons Society.
2008 Queen Ingrid’s Lecture, Åbenrå Hospital.
2010 Prize for outstanding scientific communication, University of
Southern Denmark, Denmark
2012 Marie & August Krogh award, Danish Medical Association.
2012 Award for outstanding scientific achievement, Faculty of Health Sciences, University of Southern Denmark.
2015 SEB-Codan award, Danish Medical Association.
2019 The Olav Thon award for Medical Research, University of Oslo, Norway
2020 Louis Avioli Founder Award, the American Society for Bone and Mineral Research

CURRENT APPOINTMENTS:
May 2002 Chief Physician, Department of Endocrinology, Diabetes and Metabolism, University Hospital of Odense, Odense, Denmark
May 2002 Professor of Molecular Endocrinology, University of Southern Denmark, Odense, Denmark and director for Laboratory of Molecular Endocrinology, Medical Biotechnology Center.
2013 Professor of Stem Cell Biology, Danish National Stem Cell Center (Danstem), Faculty of Health Sciences, University of Copenhagen

RESEARCH APPOINTMENTS:
Dec 89-Dec 92 PhD student, Osteoporosis Research Unit, Aarhus University Hospital, Aarhus, Denmark.
Aug 93-July 95 Postdoctoral Fellow, Department of Endocrinology and Metabolism, Mayo Clinic, Rochester, Minnesota, USA.
July 2012- July 2013 Visiting professor, Center of System Biology, Faculty of Science, University of New South Wales, Sydney, Australia.
February-March 2017 Visiting professor, The Garvan Institute for medical research, Sydney, Austrlia.

SCIENTIFIC ACTIVITIES:
Scientific Director of Stem Cell Treatment Centre, University Hospital of Odense, Odense, Denmark.

Principal investigator of the Indo-Danish Initiative of Stem Cells and Nanotechnology which is collaboration between Universities of Southern Denmark, University of Aarhus and Stem Cell Centre at Bangalore and Kerala, India,

Regular reviewer for Nature Medicine, Nature Biotechnology, Journal of bone and Mineral Research, Bone, European Journal of Clinical Investigation, Endocrinology, European Journal of Endocrinology, International Journal of Developmental Biology, Calcified Tissue International, Stem Cells, Tissue Engineering, European Journal of Hematology, Biogerontology, Osteoporosis International.

Reviewed grants for Medical Research councils in Norway, UK, Austria, Singapore, China, Finland and France. Reviewed PhD thesis (15) and Dr.Med (doctorate degree of Medical Sciences) thesis (2). Evaluation of professorships (8).

Lecturing frequently at national and international meetings. In 2015 and 2020 more than 100 presentations at national and international meetings with plenary lectures, symposia presentation, meet the professor sessions in major stem cell and endocrinology conferences including Annual meeting of Endocrine Society, Annual meetings of American Society for Bone and Mineral Research, European Calcified Tissue Society and Annual meetings of European Society of Endocrinology.

Editorship and Board Membership:
Member of editorial board of Biogerontolog (1999- 2004)
Member of editorial board of Clinical Endocrinology (2007-)
Member of editorial board of Stem Cell Reviews (2008-)
Associate editor Aging Cell (2016-)
Editor Bone (2012-)
Editor Stem Cell Research (2015-2017)
Stem Cell Research and Therapy (2014-)
Member of the Scientific-Ethical Committee of Aarhus County (1999-2001).
Board member of the Danish Society for Endocrinology (2002-2007)
Board member of the Danish Bone and Tooth Society (2000-2004)
Board Member of the Centre for Art and Science, University of Southern Denmark (2004- )
Board member of PhD graduate school of Stem Cell Research and PhD graduate school of Metabolic diseases.
Board Member of Nordic Research Foundation, Novo Nordisk Foundation (2004-2014)
Member of the advisory board of International Osteoporosis Foundation (IOF) (2009-2014)
Member of Nordic Council on Bioethics (2012-2014)
American Society for Bone and Mineral Research Ethics Advisory Committee (2014- )

Supervision:
PhD students 30, post-doctoral scientists 21, Master students 16, Medical Students (research year) 10, bachelor students 3.

Patents:
1. PCT/EP2012/060997 miRNA-138 for use in regulation of osteoblast differentiation of
hMSC
2. PCT/EP2013/059207 Identification of a novel molecule (chemical) to enhance bone cell differentiation of skeletal (mesenchymal) stem cells

Research focus
The main research focus is studying mechanisms of impaired bone formation and bone fragility during aging and in osteoporosis as well as molecular mechanisms of osteoblast (bone forming cells) differentiation of human skeletal (mesenchymal) stem cells (MSC); studying the phenomenon of biological aging of MSC with respect to lineage fate determination and how the cellular senescent phenotype can be overcome by genetic and non-genetic approaches. I have been combining clinical studies with cellular and molecular studies and employing state-of-the-art technologies of genetics and proteomics in molecular phenotyping of patients’ cohorts. I am studying the possible clinical use of MSC in tissue regeneration in a variety of diseases including fracture healing.

Research funding:
I have obtained continuous research funding as principal investigator (PI). Here is the list of my last 5 years funding as PI :
1.Novonordiskfonden (190C0057449) (2019-2021): The choir and the soloist: Studying human stromal stem cells at a single cell resolution - Changes in aging and metabolic bone diseases (3 million (M) Dkr).
2. Danmarks Frie Forskningsfond (9039-00215B) (2019-2022): Enhancement of bone regenerationby in vivo targeting of skeletal stem cells (3 M Dkr)
3. Bone Bank 2.0 (2016-2020): Inter-reg EU project: Establishing a German-Danish skeletal stem cell bank for bone regeneration therapies (5%) (1 M €)
4. Lundbeck foundation (2018) (R266-2017-4250) From stem cell transplantation to in vivo targeting: Studying the physiological role and molecular mechanisms of novel stromal (skeletal) stem cell secreted factors (0.5M dkr)
4. The Olav Thon foundation (2019-2022): Enhancement of bone regeneration by in vivo targeting of skeletal stem cells (10 M NORKr)
5. The Innovation Fund Denmark (2016-2020): Indo-Danish Centre for Musculo-Skeletal Stem Cell Targeting (10 M Dkr)
6. Novonordiskfoundation (2021-2023) The role of circulating and bone tissue microRNAs in the pathogenesis of type 2 diabetic bone fragility (3.3 M dkr)

Clinical work:
I have 40% of my time (2 days weekly) spent at the endocrine and diabetes outpatient clinic, Odense University Hospital.

Teaching:
I have responsibility for organizing Endocrinology course for biomedical students (a week course twice a year). I do regular teaching for undergraduate and postgraduate medical students and junior physicians in Endocrinology, metabolic bone diseases and osteoporosis.

 

LIST OF PUBLICATIONS

THESES:
1994 PhD thesis (University of Aarhus, Denmark): Human bone cell proliferation and differenti¬ation: effects of growth hormone and sex steroids on osteoblasts in vitro.
1997 DSc thesis (University of Aarhus, Denmark): Cellular and Molecular effects of growth hormone and estrogen on human bone cells

PUBLICATIONS:
Total number of publications: 318
Original papers 244
Invited reviews/book chapters 74
Web of Science: total articles: 240, H-index: 67, citation number 15714
Google scholar citation: H-index : 83, total citation 245557, i10-index 250

Original papers:

1- M.Kassem, E.F.Eriksen, F.Melsen, L.Mosekilde (1991) Antacid-induced osteomala¬cia. J Intern Med 229:275-80. Impact factor: 6.754

2- M.kassem, Li Mosekilde, J. Rungby, F. Melsen, Le. Mosekilde, E.F.Eriksen (1991) Formation of osteoclasts and osteoblast-like cells in long-term bone marrow cultures. Acta Path Microbiol Immunol Scand 99:262-8. Impact factor: 2.026

3- M.Kassem, L.Restilli, F. Melsen, L. Mosekilde, E.F.Eriksen (1991) Formation of osteoblast-like cells in long-term bone marrow cultures. Acta Path Microbiol Immunol Scand 99:270-4. Impact factor: 2.026

4- M.Kassem, E.F.Eriksen, L.Mosekilde (1991) Familiær hypokal¬kurisk hyperkal¬cæmi. Nordisk Medicin 4:107-??
Impact factor: 0.06

5- H.K.Nielsen, K.Brixen, M.Kassem, L.Mosekilde (1991) 1,25 dihydroxy¬vitamin D3 prevents the acute suppressive effects of gluco¬corticoids on serum osteocalcin in normal individuals. J Bone Miner Res. 6:435-41. Impact factor: 2.472

6- H.K.Nielsen, K.Brixen, M.Kassem, S.E.Christensen, L.Mosekilde (1991) Diurnal rhythm in serum osteocalcin. Relationship with sleep, growth hormone and PTH (1-84). Calcif Tissue Int 49:373-7. Impact factor: 3.275

7- M.Kassem, J. Rungby, L. Mosekilde, E.F.Eriksen (1992) Ultrastruc¬ture of human osteoblasts and associated matrix in culture. Acta Path Microbiol Immunol Scand 100:¬491-7. Impact factor: 2.026

8- H.K.Nielsen, K.Brixen, M. Kassem, P.Charles, L. Mosekilde (1992). Inhibition of the morning cortisol peak abolished the expected morning decrease in serum osteocalcin in normal males. J Clin Endocrinol Metab 74:1410-4. Impact factor: 5.789

9- D. Tornehave, B. Teisner, H. Boje-Rasmussen, J. Chemmitz, M. Kassem (1992). Fetal antigen 2 (FA2) in human fetal osteoblasts, cultured osteoblasts and osteogenic osteosarcoma cells. Anatomy and Embryology 186:271-4. Impact factor: 1.75

10- H. Boje-Rasmussen, B. Teisner, F. Bangsgaard-Pedersen, E. Yde-Andersen,
M. Kassem (1992). Quantification of foetal antigen 2 (FA2) in supernatants of cultured osteoblasts, normal human serum and serum from patients with chronic renal failure. Nephrology Dialysis Transplantation 7:902-7. Impact factor: 4.085

11. M.Kassem, W.Blum, J.Risteli, L.Mosekilde, E.F.Eriksen (1992). Effects of human Growth Hormone on proliferation and differentia¬tion of human osteoblasts in vitro. Calcif Tissue Int 52:222-6. Impact factor: 3.275

12. M.Kassem, L.Mosekilde, E.F.Eriksen (1993). 1,25 dihydroxy vitamin D3 potentiates fluoride-stimulated collagen type I production in cultures of human bone marrow stromal cells. J Bone Miner Res 12:1453-8. Impact factor: 6.314

13. M.Kassem, L.Mosekilde, E.F.Eriksen (1993) Effects of triiodothyronine on DNA synthesis and differentiation markers of human osteoblast-like cells. Biochemistry and Molecular Biology International 30:779-88. Impact factor: 0.92

14. J.Rungby, M.Kassem, E.F.Eriksen, G.Danscher (1993). The von Kossa reaction for calcium deposits: a revised version suitable also for cell cultures. Histoche¬mistry J 25:446-51. Impact factor: 2.217

15. J.Bollwerslev, S.C.Marks Jr., S.Pockwinse, M.Kassem, K.Brixen, T.Steiniche, L.Moseilde (1993) Ultrastructural investigations of bone resorptive cells in two types of autosomal dominant osteoporosis. Bone 14:865-9. Impact factor: 4.140

16. H.Brockstedt, M.Kassem, E.F.Eriksen, L.Mosekilde, F.Melsen (1993) Age- and sex-related changes in iliac cortical bone mass and remodeling. Bone 14:681-91. Impact factor: 4.140

17. M.Kassem, K. Brixen, L.Mosekilde, E.F.Eriksen (1994) Human marrow stromal osteoblast-like cells do not show reduced responsiveness to in vitro stimulation with growth hormone in patients with postmenopausal osteoporosis. Calcif Tissue Int 54:1-6. Impact factor: 3.275

18. M.kassem, C.Xu, S.Brask, E.F.Eriksen, L.Mosekilde,T.A.Kruse (1994) Familial isolated primary hyperparathyroidism: an allelic form of multiple endocrine neoplasia syndrome type I. Clinical Endocrinol 41:415-20. Impact factor: 5.455

19. M.Kassem, L.Mosekilde, E.F.Eriksen (1994) Effects of sodium fluoride on bone cells in vitro: differences in responsiveness between marrow precursors and mature osteo¬blasts. European J Endocrinol 130:381-6. Impact factor: 4.333

20. M.Kassem, K. Brixen, W. Blum, L.Mosekilde, E.F.Eriksen (1994) Normal osteoclastic and osteoblastic responses to exogenous growth hormone in patients with postmenopausal spinal osteoporosis. J Bone Miner Res 9:1365-70. Impact factor: 6.314

21. M.Kassem, K. Brixen, W. Blum, L.Mosekilde, E.F.Eriksen (1994) No evidence for reduced spontaneous or growth hormone-stimulated insulin-like growth factor (IGF)-I, IGF-II or IGF binding protein 3 (IGFBP-3) in patients with postmenopausal osteoporosis. European J Endocrinol 131:150-5. Impact factor: 4.333

22. P.Hansen, M.Kassem, K. Brixen, L. Mosekilde, O. Faergeman (1995) Effect of short term treatment with recombinant human growth hormone on lipid and lipoproteins in females and males without growth hormone deficiency. Metabolism 44:725-9. Impact factor: 5.963

23. M.Kassem, L.Mosekilde, E.F.Eriksen (1994). Growth hormone stimulates proliferation of human marrow stromal osteoblast-like cells in vitro. Growth Regulation 4:131-5. Impact factor: 2.047

24. L.Ankersen, M.Kassem, L.Østergård, E.F.Eriksen, B.F.Clark, S.Rattan (1994). Aging of human trabecular osteoblasts in culture. Archives of Gerontology and Geriatrics. 4:5-12. Impact factor: 2.241

25. K.Brixen, M.Kassem, H.K.Nielsen, A.G. Loft, A.Flyvbjerg, L.Mosekilde (1995). Short-term treatment with growth hormone stimulates osteoblastic and osteoclastic activity in osteopenic postmenopausal women: a dose-response study. J Bone Miner Res 10:1865-74. Impact factor: 6.314

26. M.Kassem, S.A.Harris, T.C.Spelsberg, B.L.Riggs (1996). Estrogen inhibits interleukin 6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors. J Bone Miner Res 11:193-9. Impact factor: 6.314

27. D.Rickard, M.Kassem, T.Hefferan, G.Sarkar, B.L.Riggs (1996). Isolation and characterization osteoblast progenitor cells from human bone marrow. J Bone Miner Res 11:312-24. Impact factor: 6.314

28. M.Kassem, S.Khosla, T.C.Spelsberg, B.L.Riggs (1996). Failure to demonstrate estrogen regulation of cytokine production in bone marrow plasma or bone marrow cell cultures in early postmenopausal women. J Clin Endocrinol Metab 81:513-8. Impact factor: 5.455

29. M.Kassem, R.Okazaki, S.A.Harris,T.C.Spelsberg, C.A.Conover, B.L.Riggs (1996). Potential mechanism of estrogen-mediated decrease in bone formation: estrogen increases production of inhibitory insulin-like growth factor-binding protein-4 in a human osteoblastic cell line with high levels of estrogen receptors. Proc Assoc Amer Physcian 108:155-64. Impact factor: 1.974

30. M.Kassem, L.Ankersen, E.F.Eriksen, B.F.C.Clark, S.I.S.Rattan (1997). Demonstra¬tion of cellular aging and senescence in human osteoblast cultures established from normal and osteoporotic bone. Osteop Int 7:514-24. Impact factor: 3.591

31. M.Kassem, C.A.Conover, S.A.Harris, T.C.Spelsberg, B.L.Riggs (1998). Estrogen effects on gene expression of insulin-like growth factors in a human cell line with high levels of estrogen receptors. Calcif Tissue Int 62:60-66. Impact factor: 3.275

32. B.Langdal, M.Kassem, M.K.Moeller, E.F.Eriksen (1998). Effects of insulin-like growth factor-I and -II with and without growth hormone on proliferation and differentiation of human osteoblasts in vitro. Europ J Clin Invest 28:176-?? Impact factor: 3.086

33. E.Gonos, A.Derventzi, M.Kveiborg, G.Agiostratidou, M.Kassem, B.Clark, P.Jat, S.Rattan (1998) Cloning and identification of genes that associate with mammalian replicative senescence. Exp Cell Res 240:66-74. Impact factor: 3.246

34. M.Kassem, K.Brixen, L.Mosekilde, W.Blum, A.Flyvbjerg (1998) Effects of growth hormone treatment on serum levels of insulin-like growth factors (IGFs) and IGF binding proteins 1-4 in postmenopausal women. Clinical Endocrinology 49:747-56 Impact factor: 5.455

35. N. Abilgaard, J.Rungby, H.Glerup, K.Brixen, M.Kassem, H.Brincker, K.Heickendorff, E.Eriksen, J.Nielsen (1998) Long-term oral pamidronate treatment inhibits osteoclastic bone resorption and bone turnover without affecting affecting osteoblastic functions in multiple myeloma Eur J Haematol 61:128-34. Impact factor: 2.595

36. M.kveiborg, M.Kassem, B.Langdahl, E.F.Eriksen, S.I.S.Rattan (1999). Telomere shortening during aging of human osteoblasts in vitro and in leucocytes in vivo: lack of excessive telomere loss in osteoporotic patients. Mech Aging Develop 106:261-71. Impact factor: 0.56

37. E.F.Eriksen, B.Langdahl, J.Rungby, M.Kassem (1999) Hormone replacement therapy prevents osteoclastic hyperactivity in early menopasue: a histomorphometric study in early postmenopausal women. J Bone Miner Res 14:1217-21. Impact factor: 6.314

38. N. Abilgaard, H.Glerup, J.Rungby, K.Bendix-Hansen, M.Kassem, K.Brixen, L.Heickendorff, J.L.Nielsen, E.Eriksen (2000) Biochemical markers of bone metabolism reflect osteoclastic and osteoblastic activity in multiple myeloma. Eur J Haematol 64:121-9. Impact factor: 2.595

39. M.Kassem, M.Kveiborg, E.F.Eriksen (2000) Transforming growth factor- production and responsiveness in human osteoblasts in vitro. Europ J Clin Invest 30:549-61. Impact factor: 3.086

40. M.Kveiborg, A.Flyvbjerg, S.I.S. Rattan, M.Kassem (2000) Changes in insulin-like growth factor system may contribute to in vitro age-related impaired osteoblast functions. Exp Gerontol 35:1061-74. Impact factor: 3.224

41. M.Christiansen, M.Kveiborg, M.Kassem, B.F.C.Clark, S.I.S.Rattan (2000) CBFA-1 and Topoisomerase I mRNA levels decline during cellular aging of human trabecular osteoblasts. J Gerontol Biol Sci 55A:B194-200. Impact factor: 4.902

42. M.Kassem, T.Kruse, F.Wong, C. Larsson, B.The (2000) Familial isolated hyperparathyroidism: a variant of MEN-1. J Clin Endocrinol Metab 85:165-7. Impact factor: 5.455

43. M.Kveiborg, S.I.S. Rattan, B.Clark, E.F.Eriksen, M.Kassem (2001) Treatment with 1,25-dihydroxyvitamin D3 reduces impairment of human osteoblast functions during cellular aging in cultrue. J Cell Physiol 186:298-306. Impact factor: 4.080

44. M.Kveiborg, A.Flyvbjerg, E.F.Eriksen, M.Kassem (2001) Calcitriol stimulates the production of insulin-like growth factor binding protein-2, -3 and –4 in human bone marrow stromal cells. Europ J Endocrinol 144:549-57. Impact factor: 4.333

45. K.Stenderup, J.Justesen, E.F.Eriksen, Suresh Rattan, M.Kassem (2001) Number and proliferative capacity of osteogenic stem cells are maintained during aging and in patients with osteoporosis. J Bone Miner Res 16:1120-9. Impact factor: 6.314

46. J.Justesen, K.Stenderup, E.F.Eriksen, M.kassem (2002) Maintenance of osteoblastic and adipocytic differentiation potential with age and osteoporosis in human marrow stromal cell cultures. Calcif Tissue Int 71:36-44. Impact factor: 3.275

47. M. Kveiborg, A.Flyvbjerg, E.F.Eriksen, M.Kassem (2001) Transforming growth factor-B stimulates the production of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in human bone marrow stromal osteoblast progenitors. J Endocrinol 169:549-61. Impact factor: 4.012

48. M.kveiborg, A.Flyvbjerg, M.Kassem (2002) Synergistic effects of 1,25-Dihydroxyvitamin D3 and TGF-beta1 on the production of insulin-like growth factor binding protein 3 in human bone marrow stromal cell cultures. APMIS. 10:410-4. Impact factor: 2.206

49. J.Justesen, K.Stenderup, E.Ebbesen, T.Steiniche, M.Kassem (2001) Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology 1:165-71. Impact factor: 3.702

50. L.Torring, L.Mosekilde, J.Justesen, E.Falk, M.Kassem (2001) Troglitazone treatment induces adipogenesis but does not affect osteogenesis in the bone marrow. Calcif Tissue Int 69:46-50. Impact factor: 3.275

51. C.Rosada, D.Melsvik, P.Ebbesen, M.Kassem (2002) The umblical cord blood: a potential source for mesenchymal stem cells. Calcif Tissue Int 72:135-42. Impact factor: 3.275

*52. J. Simonsen, C.Rosada, N.Sernici, J. Justesen, K.Stenderup, S.Rattan, T.Jensen, M.Kassem (2002). Telomerase expression extends lifespan and prevents senescence-associated impairment of osteoblast functions. Nature Biotechnology 20:592-6. Impact factor: 35.724

53. M. Kveiborg, C.Gravholdt, M.Kassem (2001) Evidence of a normal mean telomere fragment length in patients with Ullrich-Turner syndrome. Eur J Hum Genet. 9:877-9. Impact factor: 4.349

54. J. Justesen, Li. Mosekilde, K.Stenderup, J.Gaster, J. Seckl , M.Kassem (2004). Mice deficient in 11 b-hydroxysteroid dehydrogense type 1 lack bone marrow adipocytes but maintain normal bone formation. Endocrinology 145:1916-25. Impact factor: 3.961

55. Villablanca A, Wassif WS, Smith T, Hoog A, Vierimaa O, Kassem M, Dwight T, Forsberg L, Du Q, Learoyd D, Jones K, Stranks S, Juhlin C, Teh BT, Carling T, Robinson B, Larsson C. (2002) Involvement of the MEN1 gene locus in familial isolated hyperparathyroidism. Eur J Endocrinol 147:313-22. Impact factor: 4.333

56. J.Justesen, K.Stenderup, S.B.Pedersen, M.Kassem (2004). Subcutaneous adipocytes differentiate into bone forming cells in vitro and in vivo. Tissue Engineering 10:381-91. Impact factor: 3.508

*57. K.Stenderup, J.Justesen, C.Clausen, M.Kassem (2003). Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone 33:919-26. Impact factor: 4.140

58. K.Stenderup, J.Justesen, C.Clausen, M.Kassem (2004). Aged human marrow stromal cells maintain bone forming capaciyt in vivo evaluated using an improved method of visulaization. Biogerontology 5:107-18. Impact factor: 3.702

59. E. Paschalis, A. Boskey, M.Kassem, E.F.Eriksen (2003) Effect of hormone replacement therapy on bone quality in early menopausal women. J Bone Miner Res 18:955-9. Impact factor: 6.314

60. Parkinson C, Kassem M, Heickendorff L, Flyvbjerg A, Trainer PJ (2003) Pegvisomant-induced serum insulin-like growth factor-I normalization in patients with acromegaly returns elevated markers of bone turnover to normal. J Clin Endocrinol Metab. 88:5650-5. Impact factor: 5.455

*61. Abdallah BM, Jensen CH, Gutierrez G, Leslie RG, Jensen TG, Kassem M (2004) Regulation of human skeletal stem cells differentiation by Dlk1/Pref-1. J Bone Miner Res. 19:841-52. Impact factor: 6.314

62. Bentzon JF, Stenderup K, Hansen FD, Schroder HD, Abdallah BM, Jensen TG, Kassem M (2005) Tissue distribution and engraftment of human mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene. Biochem Biophys Res Commun. 330:633-40. Impact factor: 2.559

63. Abdallah BM, Haack-Sorensen M, Burns JS, Elsnab B, Jakob F, Hokland P,
Kassem M (2005) Maintenance of differentiation potential of human bone marrow mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene despite of extensive proliferation. Biochem Biophys Res Commun. 326:527-38. Impact factor: 2.559

64. Fink T, Abildtrup L, Fogd K, Abdallah BM, Kassem M, Ebbesen P, Zachar V (2004) Induction of adipocyte-like phenotype in human mesenchymal stem cells by hypoxia. Stem Cells. 22:1346-55. Impact factor: 5.587

*65. Serakinci N, Guldberg P, Burns JS, Abdallah B, Schrodder H, Jensen T, Kassem M (2004). Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene. 23:5095-8. Impact factor: 6.854

66. Niemeier A, Kassem M, Toedter K, Wendt D, Ruether W, Beisiegel U, Heeren J (2005). Expression of LRP1 by human osteoblasts: a mechanism for the delivery of lipoproteins and vitamin K1 to bone. J Bone Miner Res. 20:283-93. Impact factor: 6.314

67. Rejnmark L, Vestergaard P, Kassem M, Christoffersen BR, Kolthoff N, BrixenK, Mosekilde L (2004). Fracture risk in perimenopausal women treated with beta-blockers. Calcif Tissue Int. 75:365-72. Impact factor: 3.275

*68. Burns JS, Abdallah BM, Guldberg P, Rygaard J, Schroder HD, Kassem M (2005). Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells. Cancer Res. 65:3126-35. Impact factor: 9.130

69. Abdallah BM, Stilgren LS, Nissen N, Kassem M, Jorgensen HR, Abrahamsen B (2005). Increased RANKL/OPG mRNA ratio in iliac bone biopsies from women with hip fractures. Calcif Tissue Int. 76:90-7. Impact factor: 3.275

*70. Kratchmarova I, Blagoev B, Haack-Sorensen M, Kassem M, Mann M (2005) Mechanisms of divergent growth factor effects in mesenchymal stem cell differentiation. Science 308:1472-7. Impact factor: 37.205

*71. Foster LJ, Zeemann PA, Li C, Mann M, Jensen ON, Kassem M (2005)
Differential expression profiling of membrane proteins by quantitative
proteomics in a human mesenchymal stem cell line undergoing osteoblast
differentiation. Stem Cells 23:1367-77. Impact factor: 5.587

72. Kassem M, Burns J, Abd-Allah B (2005) Blood vessels engineered from human cells. Lancet 366:891-2. Impact factor: 53.254

73. Ebert R, Ulmer M, Zeck S, Meissner-Weigl J, Schneider D, Stopper H, Schupp N, Kassem M, Jakob F (2006) Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro. Stem Cells. 24:12226-35. Impact factor: 5.587

76. Abdallah BM, Haack-Sorensen M, Fink T, Kassem M (2006) Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females. Bone. 39:181-8. Impact factor: 4.140

77. Serakinci N, Hoare SF, Kassem M, Atkinson SP, Keith N (2006) Telomerase promoter reprogramming and interaction with general transcription factors in human mesenchymal stem cells. Reg Med 1:125-31. Impact factor: 1.152

78. Norgaard R, Kassem M, Rattan SI (2006) Heat shock-induced enhancement of osteoblastic differentiation of hTERT-immortalized mesenchymal stem cells. Ann N Y Acad Sci. 1067:443-7. Impact factor: 4.039

79. Woo C, Li H, Baatrup A, Krause A, Kassem M, Bunger C, Lind M (2006)
Effects of bone protein extract on human mesenchymal stem cells proliferation and differentiation. J Biomed Mater Res A. 79:552-6. Impact factor: 2.308

80. Fierro-Monti I, Mohammed S, Matthiesen R, Santoro R, Burns JS, Williams DJ, Proud CG, Kassem M, Jensen ON, Roepstorff P (2006) Quantitative proteomics identifies Gemin5, a scaffolding protein involved in ribonucleoprotein assembly, as a novel partner for eukaryotic initiation factor 4E. J Proteome Res. 5:1367-78. Impact factor: 4.268

81. Imel EA, Peacock M, Pitukcheewanont P, Heller HJ, Ward LM, Shulman D, Kassem M, Rackoff P, Zimering M, Dalkin A, Drobny E, Colussi G, Shaker JL, Hoogendoorn EH, Hui SL, Econs MJ (2006) Sensitivity of fibroblast growth factor 23 measurements in tumor-induced osteomalacia. J Clin Endocrinol Metab. 91:2055-61. Impact factor: 5.455

82. Abdallah BM, Boissy P, Tan Q, Dahlgaard J, Traustadottir GA, Kupisiewicz K,Laborda J, Delaisse JM, Kassem M (2007) DLK1/FA1 regulates the function of human bone marrow mesenchymal stem cells (hMSC) by modulating gene expression of pro-inflammatory cytokines and immune-response-related factors. J Biol Chem. 282:7339-51. Impact factor: 4.010

83. Mygind T, Stiehler M, Baatrup A, Li H, Zou X, Flyvbjerg A, Kassem M, Bunger C (2007) Mesenchymal stem cell ingrowth and differentiation on coralline hydroxyapatite scaffolds. Biomaterials;28:1036-47. Impact factor: 8.806

84. Bentzon JF, Weile C, Sondergaard CS, Hindkjaer J, Kassem M, Falk E (2006).
Smooth muscle cells in atherosclerosis originate from the local vessel wall and not circulating progenitor cells in ApoE knockout mice. Arterioscler Thromb Vasc Biol. 26:2696-702. Impact factor: 6.607

85. Qiu W, Andersen TE, Bollerslev J, Mandrup S, Abdallah BM, Kassem M (2007) Patients with High Bone Mass Phenotype Exhibit Enhanced Osteoblast Differentiation and Inhibition of Adipogenesis of Human Mesenchymal Stem cells. J Bone Miner Res. 22:1720-31. Impact factor: 6.314

86. Rinne S, Ramstad Kleiveland C, Kassem M, Lea T, Lundanes E, Greibrokk T (2007). Fast and simple online sample preparation coupled with capillary LC-MS/MS for determination of prostaglandins in cell culture supernatants.
J Sep Sci. 30:1860-9. Impact factor: 2.415

87. Abdallah BM, Ding M, Jensen CH, Ditzel N, Flyvbjerg A, Jensen TG,
Dagnaes-Hansen F, Gasser JA, Kassem M (2007). Dlk1/FA1 is a novel endocrine regulator of bone and fat mass and its serum level is modulated by growth hormone. Endocrinology. 148:3111-21. Impact factor: 3.961

88. Bentzon JF, Sondergaard CS, Kassem M, Falk E (2007). Smooth muscle cells healing atherosclerotic plaque disruptions are of local, not blood, origin in apolipoprotein E knockout mice. Circulation. 116:2053-61 Impact factor: 18.88

89. Stiehler M, Lind M, Mygind T, Baatrup A, Dolatshahi-Pirouz A, Li H, Foss M,
Besenbacher F, Kassem M, Bünger C (2008) Morphology, proliferation, and osteogenic differentiation of mesenchymal stem cells cultured on titanium, tantalum, and chromium surfaces. J Biomed Mater Res A. 86:448-58. Impact factor: 2.308

90. Li YM, Schilling T, Benisch P, Zeck S, Meissner-Weigl J, Schneider D, Limbert
C, Seufert J, Kassem M, Schütze N, Jakob F, Ebert R (2007). Effects of high glucose on mesenchymal stem cell proliferation and differentiation. Biochem Biophys Res Commun. 363:209-15. Impact factor: 2.559

91. Frandsen U, Porneki AD, Floridon C, Abdallah BM, Kassem M (2007) Activin B mediated induction of Pdx1 in human embryonic stem cell derived embryoid bodies. Biochem Biophys Res Commun. 362:568-74. Impact factor: 2.559

92. Zou L, Zou X, Chen L, Li H, Mygind T, Kassem M, Bünger C (2008) Multilineage differentiation of porcine bone marrow stromal cells associated with specific gene expression pattern. J Orthop Res. 26:713-20. Impact factor: 3.14

93. Post S, Abdallah BM, Bentzon JF, Kassem M (2008) Demonstration of the presence of independent pre-osteoblastic and pre-adipocytic cell populations in bone marrow-derived mesenchymal stem cells. Bone. 43:32-39. Impact factor: 4.140

94. Grønbæk K, Ralfkiaer U, Dahl C, Hother C, Burns JS, Kassem M, Worm J,
Ralfkiaer EM, Knudsen LM, Hokland P, Guldberg P (2008). Frequent hypermethylation of DBC1 in malignant lymphoproliferative neoplasms. Mod Pathol. 21:632-8. Impact factor: 6.655

95. Prawitt J, Niemeier A, Kassem M, Beisiegel U, Heeren J (2008) Characterization of lipid metabolism in insulin-sensitive adipocytes differentiated from immortalized human mesenchymal stem cells. Exp Cell Res. 314:814-24. Impact factor: 3.246

96. Kleiveland CR, Kassem M, Lea T (2008). Human mesenchymal stem cell proliferation is regulated by PGE2 through differential activation of cAMP-dependent protein kinase isoforms. Exp Cell Res. 314:1831-8. Impact factor: 3.246

97. Prokhorova TA, Harkness LM, Frandsen U, Ditzel N, Burns JS, Schroeder HD,
Kassem M (2008). Teratoma Formation by Human Embryonic Stem Cells is site-dependent and enhanced by the presence of Matrigel. Stem Cells Dev. 18:47-54. Impact factor: 3.315

98. Bjerre L, Bünger CE, Kassem M, Mygind T (2008). Flow perfusion culture of human mesenchymal stem cells on silicate-substituted tricalcium phosphate scaffolds. Biomaterials. 29:2616-27. Impact factor: 8.806

99. Zou L, Zou X, Chen L, Li H, Mygind T, Kassem M, Bünger C (2008). Effect of hyaluronan on osteogenic differentiation of porcine bone marrow stromal cells in vitro. J Orthop Res. 26:713-20. Impact factor: 3.14

100. Rinne Dahl S, Ramstad Kleiveland C, Kassem M, Lea T, Lundanes E, Greibrokk T (2008) Detecting pM concentrations of prostaglandins in cell culture supernatants by
capillary SCX-LC-MS/MS. J Sep Sci. 31:2627-33. Impact factor:

101. Thingholm TE, Larsen MR, Ingrell CR, Kassem M, Jensen ON (2008) TiO2-Based Phosphoproteomic Analysis of the Plasma Membrane and the Effects of Phosphatase Inhibitor Treatment. J Proteome Res. 7:3304-13. Impact factor: 4.268

102. Diederichsen AC, Møller JE, Thayssen P, Junker AB, Videbaek L, Saekmose SG,
Barington T, Kristiansen M, Kassem M (2008) Effect of repeated intracoronary injection of bone marrow cells in patients with ischaemic heart failure the Danish stem cell study--congestive heart failure trial (DanCell-CHF). Eur J Heart Fail. 10:661-7. Impact factor: 10.683

103. Burns JS, Abdallah BM, Shrøder HD, Kassem M (2008) The histopathology of a human mesenchymal stem cell experimental tumor model: support for an hMSC origin for Ewing's sarcoma? Histol Histopathol. 23:1229-40. Impact factor: 2.025

104. Stiehler M, Bünger C, Baatrup A, Lind M, Kassem M, Mygind T (2009).
Effect of dynamic 3-D culture on proliferation, distribution, and osteogenic
differentiation of human mesenchymal stem cells. J Biomed Mater Res A. 89:96-107. Impact factor: 2.308

105. Gjerstorff MF, Harkness L, Kassem M, Frandsen U, Nielsen O, Lutterodt M,
Møllgård K, Ditzel HJ (2008) Distinct GAGE and MAGE-A expression during early human development indicate specific roles in lineage differentiation.
Hum Reprod. 23:2194-201. Impact factor: 4.949

106. Bay-Jensen AC, Tabassi NC, Sondergaard LV, Andersen TL, Dagnaes-Hansen F,
Garnero P, Kassem M, Delaisse JM (2009). The response to estrogen deprivation on cartilage collagen degradation markers; CTX-II is unique compared to other markers of collagen turnover. Arthritis Res Ther. 11:R9. Impact factor: 4.269

107. Prokhorova TA, Rigbolt KT, Johansen PT, Henningsen J, Kratchmarova I, Kassem
M, Blagoev B (2009). SILAC-labeling and quantitative comparison of the membrane proteomes of self-renewing and differentiating human embryonic stem cells.
Mol Cell Proteomics. 8:959-70. Impact factor: 6.540

108. Heile AM, Wallrapp C, Klinge PM, Samii A, Kassem M, Silverberg G, Brinker T (2009). Cerebral transplantation of encapsulated mesenchymal stem cells improves cellular
pathology after experimental traumatic brain injury. Neurosci Lett. 463:176-81. Impact factor: 2.180

109. Liedert A, Kassem M, Claes L, Ignatius A (2009). Mechanosensitive promoter region in
the human HB-GAM gene. Biochem Biophys Res Commun. 387:289-93. Impact factor: 2.559

110. Chen M, Feng W, Cao H, Zou L, Chen C, Baatrup A, Nielsen AB, Li H, Kassem M,
Zou X, Bünger C (2009). A traditional Chinese medicine formula extracts stimulate
proliferation and inhibit mineralization of human mesenchymal stem cells in
vitro. J Ethnopharmacol. 125:75-82. Impact factor: 3.115

111. Gjerstorff M, Burns JS, Nielsen O, Kassem M, Ditzel H (2009). Epigenetic modulation
of cancer-germline antigen gene expression in tumorigenic human mesenchymal stem
cells: implications for cancer therapy. Am J Pathol. 175:314-323. Impact factor: 4.069

112. Hald A, Hansen RR, Thomsen MW, Ding M, Croucher PI, Gallagher O, Ebetino FH,
Kassem M, Heegaard AM (2009). Cancer-induced bone loss and associated pain-related
behavior is reduced by risedronate but not its phosphonocarboxylate analog:
NE-10790-85. Int J Cancer. 125:1177 Impact factor: 6.513

113. Dahl SR, Kleiveland CR, Kassem M, Lea T, Lundanes E, Greibrokk T (2009).
Determination of thromboxanes, leukotrienes and lipoxins using high-temperature
capillary liquid chromatography-tandem mass spectrometry and on-line sample
preparation. J Chromatogr A. 1216:4648-54. Impact factor: 4.169

114. Weber C, Pohl S, Potner R, Wallrapp C, Kassem M, Geigle P, Czermak P (2007). Cultivation and Differentiation of Encapsulated hMSC-TERT in a Disposable Small-Scale Syringe-Like Fixed Bed Reactor. Open Biomed Eng J. 1:64-70. Impact factor: 0.87

115. Weber C, Pohl S, Potner R, Wallrapp C, Kassem M, Geigle P, Czermak P (2007). Expansion and harvesting of hMSC-TERT. Open Biomed Eng J. 1:38-46. Impact factor: 0.87

116. Kraft DC, Bindslev DA, Melsen B, Abdallah BM, Kassem M, Klein-Nulend J (2010).
Mechanosensitivity of dental pulp stem cells is related to their osteogenic
maturity. Eur J Oral Sci. 118:29-38. Impact factor: 1.655

117. Harkness L, Taipaleenmaki H, Mahmood A, Frandsen U, Saamanen AM, Kassem M,
Abdallah BM (2009). Isolation and differentiation of chondrocytic cells derived from
human embryonic stem cells using dlk1/FA1 as a novel surface marker. Stem Cell
Rev. 5:353-368. Impact factor: 5.587

118. Sondergaard BC, Schultz N, Madsen SH, Bay-Jensen AC, Kassem M, Karsdal MA (2009). MAPKs are essential upstream signaling pathways in proteolytic cartilage
degradation - divergence in pathways leading to aggrecanase and MMP-mediated
articular cartilage degradation. Osteoarthritis Cartilage. 18:279-88. Impact factor: 5.454

119. Larsen KH, Frederiksen CM, Burns JS, Abdallah BM, Kassem M (2009). Identifying A
Molecular Phenotype for Bone Marrow Stromal Cells With In Vivo Bone Forming
Capacity. J Bone Miner Res. 25:796-808 Impact factor: 6.314

120. Jensen T, Dolatshahi-Pirouz A, Foss M, Baas J, Lovmand J, Duch M, Pedersen FS,
Kassem M, Bunger C, Soeballe K, Besenbacher F (2010). Interaction of human mesenchymal stem cells with osteopontin coated hydroxyapatite surfaces. Colloids Surf B
Biointerfaces. 75:186-93. Impact factor: 3.997

121. Diederichsen AC, Møller JE, Thayssen P, Videbæk L, Sækmose SG, Barington T, Kassem M (2010). Changes in left ventricular filling patterns efter repeated injections of autologus bone marrow cells in heart failure patients. Scand Cardiovasc J. 44:139-45. Impact factor: 1.449

122. Qiu W, Hu Y, Andersen TE, Jafari A, Li N, Chen W, Kassem M (2010).Tumour necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signalling and C/EBP. J Biol Chem 285:14438-49 Impact factor: 4.010

123. Frost M, Andersen TE, Yadav V, Brixen K, Karsenty G, Kassem M (2010). Patients with high bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin. J Bone Miner Res 25:673-5. Impact factor: 6.314

124. Mahmood A, Harkness L, Schrøder HD, Abdallah BM, Kassem M (2010). Enhanced differentiation of human embryonic stem cells to mesenchymal progenitors by inhibition of TGF-beta/Activin/Nodal signalling using SB-431542. J Bone Miner Res 6:1216-33
125. Henriksen J, Stabell M, Meza-Zepeda LA, Lauvrak SA, Kassem M, Myklebost O (2010). Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells. BMC Cancer 10: 329 Impact factor: 3.288

126. Isa A, Nehlin JO, Sabir HJ, Andersen TE, Gaster M, Kassem M, Barington T (2010). Imapired cell surface expression of HLA-B antigens on mesenchymal stem cells and muscle cell progenitor. Plos One 5:e10900 Impact factor: 2.766

127. Harkness L, Mahmood A, Ditzel N, Abdallah BM, Nygaard JV, Kassem M. (2011) Selective isolation and differentiation of a stromal population of human embryonic stem cells with osteogenic potential. Bone. 48:231-41 Impact factor: 4.140

128. Andersen MØ, Nygaard JV, Burns JS, Raarup MK, Nyengaard JR, Bünger C, Besenbacher F, Howard KA, Kassem M, Kjems J (2010). siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells. Mol Ther. 18:2018-27. Impact factor: 6.825

129. Harkness L, Rasmussen IA, Erb K, Kassem M (2010). Derivation and characterisation of hESC lines from supernumerary embryos, experience from Odense, Denmark. In Vitro Cell Dev Biol Anim. 46:259-68. Impact factor: 1.447

130. Burns JS, Rasmussen PL, Larsen KH, Schrøder HD, Kassem M (2010). Parameters in three-dimensional osteospheroids of telomerized human mesenchymal (stromal) stem cells grown on osteoconductive scaffolds that predict in vivo bone-forming potential. Tissue Eng Part A. 16:2331-42. Impact factor: 3.508

131. Seefried L, Mueller-Deubert S, Schwarz T, Lind T, Mentrup B, Kober M, Docheva D, Liedert A, Kassem M, Ignatius A, Schieker M, Claes L, Wilke W, Jakob F and Ebert R (2010) A small scale cell culture system to analyze mechanobiology using reporter gene
constructs and polyurethane dishes. eCell and Biomaterial 20:344-55. Impact factor: 3.667

132. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B (2011). System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 4:rs3. Impact factor: 6.494

133. Frost M, Andersen T, Gossiel F, Hansen S, Bollerslev J, Van Hul W, Eastell R, Kassem M, Brixen K (2011). Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high bone mass phenotype due to a mutation in Lrp5. J Bone Miner Res. 26:1721-8. Impact factor: 6.314

134. Saeed H, Abdallah BM, Ditzel N, Catala-Lehnen P, Qiu W, Amling M, Kassem M (2011).Telomerase-deficient mice exhibit bone loss due to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment. J Bone Miner Res. 26:1494-505 Impact factor: 6.314

135. Abdallah BM, Ditzel N, Mahmood A, Isa A, Traustadottir GA, Schilling AF, Ruiz-Hidalgo M, Laborda J, Amling M, Kassem M (2011). DLK1 is a novel regulator of bone mass that mediates estrogen-deficiency induced bone loss in mice. J Bone Miner Res. 26:1457-71 Impact factor: 6.314

136. Dolatshahi-Pirouz A, Jensen TH, Kolind K, Bünger C, Kassem M, Foss M, Besenbacher F (2011). Cell shape and spreading of stromal (mesenchymal) stem cells cultured on fibronectin coated gold and hydroxyapatite surfaces. Colloids Surf B Biointerfaces. 84:18-25. Impact factor: 3.997

137. Seefried L, Mueller-Deubert S, Schwarz T, Lind T, Mentrup B, Kober M, Docheva D, Liedert A, Kassem M, Ignatius A, Schieker M, Claes L, Wilke W, Jakob F, Ebert R (2010). A small scale cell culture system to analyze mechanobiology using reporter gene constructs and polyurethane dishes. Eur Cell Mater. 20:344-55. Impact factor: 3.667

138. Taipaleenmäki H, Abdallah BM, Aldahmash A, Säämänen AM, Kassem M (2011). Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations. Exp Cell Res. 317:745-56. Impact factor: 3.246

139. Tormin A, Li O, Brune JC, Walsh S, Schütz B, Ehinger M, Ditzel N, Kassem M, Scheding S (2011). CD146 expression on primary non-hematopoietic bone marrow stem cells correlates to in situ localization. Blood. 117:5067-77 Impact factor: 13.164

140. Limbert C, Päth G, Ebert R, Rothhammer V, Kassem M, Jakob F, Seufert J (2011). PDX1- and NGN3-mediated in vitro reprogramming of human bone marrow-derived mesenchymal stromal cells into pancreatic endocrine lineages. Cytotherapy. 13:802-13. Impact factor: 3.203

141. Eskildsen T, Taipaleenmäki H, Stenvang J, Abdallah BM, Ditzel N, Nossent AY, Bak M, Kauppinen S, Kassem M (2011). MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo. Proc Natl Acad Sci U S A. 108:6139-44. Impact factor: 9.504

142. Bjerre L, Bünger C, Baatrup A, Kassem M, Mygind T (2011). Flow perfusion culture of human mesenchymal stem cells on coralline hydroxyapatite scaffolds with various pore sizes.
J Biomed Mater Res A. 97:251-63. Impact factor: 2.308

143. Harkness L, Novikov SM, Beermann J, Bozhevolnyi SI, Kassem M (2012).Identification of Abnormal Stem Cells Using Raman Spectroscopy. Stem Cells Dev.; 12:2152-9. Impact factor: 3.315

144. D'Andrea FP, Horsman MR, Kassem M, Overgaard J, Safwat A. (2012).
Tumourigenicity and radiation resistance of mesenchymal stem cells. Acta Oncol. 51:669-79. Impact factor: 2.997

145. Taipaleenmäki H, Harkness L, Chen L, Larsen KH, Säämänen AM, Kassem M, Abdallah BM (2012). The crosstalk between transforming growth factor-β1 and delta like-1 mediates early chondrogenesis during embryonic endochondral ossification. Stem Cells. 30:304-13. Impact factor: 5.587

146. Saeed H, Taipaleenmäki H, Aldahmash AM, Abdallah BM, Kassem M. (2012).
Mouse Embryonic Fibroblasts (MEF) Exhibit a Similar but not Identical Phenotype to Bone Marrow Stromal Stem Cells (BMSC). Stem Cell Rev. 8:318-28. Impact factor: 5.587

147. Qiu W, Chen L, Kassem M (2011). Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells. Biochem Biophys Res Commun. 413:98-104. Impact factor: 2.559

148. Burns JS, Kristiansen M, Kristensen LP, Larsen KH, Nielsen MO, Christiansen H, Nehlin J, Andersen JS, Kassem M (2011). Decellularized matrix from tumorigenic human mesenchymal stem cells promotes neovascularization with galectin-1 dependent endothelial interaction. PLoS One. 6:e21888. Impact factor: 2.766

149. D'Andrea FP, Safwat A, Kassem M, Gautier L, Overgaard J, Horsman MR (2011).
Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance. Radiother Oncol. 99:373-8. Impact factor: 4.942

150. Abdallah BM, Bay-Jensen AC, Srinivasan B, Tabassi NC, Garnero P, Delaissé JM, Khosla S, Kassem M (2011). Estrogen inhibits Dlk1/FA1 production: a potential mechanism for estrogen effects on bone turnover. J Bone Miner Res. 26:2548-51. Impact factor: 6.314

151. Aldahmash A, Haack-Sørensen M, Al-Nbaheen M, Harkness L, Abdallah BM, Kassem M (2011). Human serum is as efficient as fetal bovine serum in supporting proliferation and differentiation of human multipotent stromal (mesenchymal) stem cells in vitro and in vivo. Stem Cell Rev. 7:860-8. Impact factor: 5.587

152. Andersen DC, Kortesidis A, Zannettino AC, Kratchmarova I, Chen L, Jensen ON, Teisner B, Gronthos S, Jensen CH, Kassem M (2011). Development of novel monoclonal antibodies that define differentiation stages of human stromal (mesenchymal) stem cells.
Mol Cells. 32(2):133-42. Impact factor: 14.248

153. Heinonen J, Taipaleenmäki H, Roering P, Takatalo M, Harkness L, Sandholm J, Uusitalo-Järvinen H, Kassem M, Kiviranta I, Laitala-Leinonen T, Säämänen AM (2011).
Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes. Osteoarthritis Cartilage. 19:1026-35. Impact factor: 5.454

154. Al-Nbaheen M, Vishnubalaji R, Ali D, Bouslimi A, Al-Jassir F, Megges M, Prigione A, Adjaye J, Kassem M, Aldahmash A (2012). Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential. Stem Cell Rev. 9:32-43 Impact factor: 5.587

155. D'Andrea FP, Safwat A, Burns JS, Kassem M, Horsman MR, Overgaard J (2012). Tumour microenvironment and radiation response in sarcomas originating from tumourigenic human mesenchymal stem cells. Int J Radiat Biol. 88:457-465. Impact factor: 1.687

156. Larsen SA, Kassem M, Rattan SI (2012). Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells. Chem Cent J. Mar 17;6(1):18. Impact factor: 2.284

157. Elseberg CL, Leber J, Salzig D, Wallrapp C, Kassem M, Kraume M, Czermak P (2012). Microcarrier-based expansion process for hMSCs with high vitality and undifferentiated characteristics. Int J Artif Organs. Feb;35(2):93-107 Impact factor:1.133

158. Harkness L, Novikov SM, Beermann J, Bozhevolnyi SI, Kassem M (2012).Identification of Abnormal Stem Cells Using Raman Spectroscopy. Stem Cells Dev.; 12:2152-9. Impact factor: 3.315

159. Taipaleenmäki H, Harkness L, Chen L, Larsen KH, Säämänen AM, Kassem M, Abdallah BM (2012).The Cross-talk Between TGF-β1 and Dlk1 Mediates Early Chondrogenesis During Embryonic Endochondral Ossification. Stem Cells. Feb;30(2):304-13 Impact factor: 5.587

160. Andries A, Niemeier A, Støving RS, Abdallah BA, Wolf AM, Hørder K, Kassem M (2012). Serum Levels of Fetal Antigen 1 in Extreme Nutritional States. ISRN Endocrinology, Article ID 592648, doi:10.5402/2012/592648. Impact factor: 0.38

161. Kristensen LP, Chen L, Nielsen MO, Qanie DW, Kratchmarova I, Kassem M, Andersen JS (2012). Temporal profiling and pulsed SILAC labeling identify novel secreted proteins during ex vivo osteoblast differentiation of human stromal stem cells. Mol Cell Proteomics. 10:989-1007 Impact factor: 6.540

162. Sabir HJ, Nehlin JO, Qanie D, Harkness L, Prokhorova TA, Blagoev B, Kassem M, Isa A, Barington T (2013). Separate developmental programs for HLA-A and -B cell surface expression during differentiation from embryonic stem cells to lymphocytes, adipocytes and osteoblasts.
PLoS One. 8(1):e54366. Impact factor: 2.766

163. Quint P, Ruan M, Pederson L, Kassem M, Westendorf JJ, Khosla S, Oursler MJ (2013).
Sphingosine 1-Phosphate (S1P) Receptors 1 and 2 Coordinately Induce Mesenchymal Cell Migration through S1P Activation of Complementary Kinase Pathways. J Biol Chem. 2013 288(8):5398-406. Impact factor: 4.010

164. Pang CN, Tay AP, Aya C, Twine NA, Harkness L, Hart-Smith G, Chia SZ, Chen Z, Deshpande NP, Kaakoush NO, Mitchell HM, Kassem M, Wilkins MR (2013). Tools to Co-visualize and Co-analyse Proteomic data with Genomes and Transcriptomes: validation of genes and alternative mRNA splicing. J Proteome Res.13:84-98. Impact factor: 4.268

165. Jensen J, Rölfing JH, Svend Le DQ, Kristiansen AA, Nygaard JV, Hokland LB, Bendtsen M, Kassem M, Lysdahl H, Bünger CE (2013). Surface-modified functionalized polycaprolactone scaffolds for bone repair: In vitro and in vivo experiments. J Biomed Mater Res A. 102:2993-3003. Impact factor: 2.308

166. Andersen DC, Laborda J, Baladron V, Kassem M, Sheikh SP, Jensen CH (2013).Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration. Development. 140:3743-53 Impact factor: 5.843

167. Al-Toub M, Almusa A, Almajed M, Al-Nbaheen M, Kassem M, Aldahmash A, Alajez NM. (2013) Pleiotropic effects of cancer cells' secreted factors on human stromal (mesenchymal) stem cells. Stem Cell Res Ther. 2013 Sep 17;4(5):114. doi: 10.1186/scrt325. Impact factor: 4.963

168. Chen L, Holmstrøm K, Qiu W, Ditzel N, Shi K, Hokland LB, Kassem M (2014). MicroRNA-34a Inhibits osteoblast differentiation and in vivo bone formation of human stromal stem cells. Stem Cells. 32:902-12. Impact factor: 5.587

169. Pang CN, Tay AP, Aya C, Twine NA, Harkness L, Hart-Smith G, Chia SZ, Chen Z, Deshpande NP, Kaakoush NO, Mitchell HM, Kassem M, Wilkins MR (2014).
Tools to covisualize and coanalyze proteomic data with genomes and transcriptomes: validation of genes and alternative mRNA splicing. J Proteome Res. 13(1):84-98. Impact factor: 4.268

170. Hamam D, Ali D, Vishnubalaji R, Hamam R, Al-Nbaheen M, Chen L, Kassem M, Aldahmash A, Alajez NM. microRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (skeletal) stem cells. Cell Death Dis. 2014 Oct 30;5:e1499. doi: 10.1038/cddis.2014.462. Impact factor: 5.638

171. Hansen M, Nyby S, Eifer Møller J, Videbæk L, Kassem M, Barington T, Thayssen P, Diederichsen AC. Intracoronary injection of CD34-cells in chronic ischemic heart failure: 7 years follow-up of the DanCell study. Cardiology. 2014;129(2):69-74 Impact factor: 1.994

172. Qiu W, Kassem M (2014). miR-141-3p inhibits human stromal (mesenchymal) stem cell proliferation and differentiation. Biochim Biophys Acta. 1843(9):2114-21. doi: 10.1016/j.bbamcr.2014.06.004. Impact factor: 3.679

173. N.Twine, L. Chen, C. N. Pang, M. R.Wilkins, M. Kassem (2014). Identification of differentiation-stage specific markers that define the ex vivo osteoblastic phenotype. Bone 67: 23–32. Impact factor: 4.140

174. Rolandsson S, Andersson Sjöland A, Brune JC, Li H, Kassem M, Mertens F, Westergren A, Eriksson L, Hansson L, Skog I, Bjermer L, Scheding S, Westergren-Thorsson G.
Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells. BMJ Open Respir Res. 2014 May 17;1(1). Impact factor: 2.413

175. Li H, Ghazanfari R, Zacharaki D, Ditzel N, Isern J, Ekblom M, Méndez-Ferrer S, Kassem M, Scheding S. Low/negative expression of PDGFR-α identifies the candidate primary mesenchymal stromal cells in adult human bone marrow.
Stem Cell Reports. 2014 Dec 9;3(6):965-74. Do. Impact factor: 6.537

176. Tay AP, Pang CN, Twine NA, Hart-Smith G, Harkness L, Kassem M, Wilkins MR.
Proteomic Validation of Transcript Isoforms, Including Those Assembled from RNA-Seq Data. J Proteome Res.14:3541-54. Impact factor: 4.268

 

177. Sanz-Nogués C1, Horan J, Thompson K, Howard L, Ryan G, Kassem M, O'Brien T.J (2015). Inefficiency in macromolecular transport of SCS-based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells.
Biomed Mater Res A. 103:3676-88. Impact factor: 2.308

178. Abdallah BM, Ditzel N, Laborda J, Karsenty G, Kassem M (2015).
DLK1 regulates whole body glucose metabolism: A negative feedback regulation of the osteocalcin-insulin loop. Diabetes. 64:3069-80 Impact factor: 7.273

179. He Y, Zheng Q, Jiang M, Sun S, Christiansen TG, Kassem M, Karsdal MA, Bay-Jensen AC. The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. PLoS One. 2015 Apr 24;10(4):e0122700. Impact factor: 2.766

180. Khan AM, Babcock AA, Saeed H, Myhre CL, Kassem M, Finsen B.
Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype.
Neurobiol Aging. 2015 Jun;36(6):2164-75. Impact factor: 5.153

181. Jafari A, Siersbaek MS, Chen L, Qanie D, Zaher W, Abdallah BM, Kassem M (2015).
Pharmacological Inhibition of Protein Kinase G1 Enhances Bone Formation by Human Skeletal Stem Cells Through Activation of RhoA-Akt Signaling.
Stem Cells. 33:2219-31. Impact factor: 5.587

182. Vishnubalaji R, Hamam R, Abdulla MH, Mohammed MA, Kassem M, Al-Obeed O, Aldahmash A, Alajez NM. Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer.
Cell Death Dis. 2015 Jan 22;6:e1614. doi: Impact factor: 5.638

183. Saeed H, Qiu W, Li C, Flyvbjerg A, Abdallah BM, Kassem M (2015).
Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway. Biogerontology. 16:733-45. Impact factor: 3.702

184. Chen L, Shi K, Frary CE, Ditzel N, Hu H, Qiu W, Kassem M (2015). Inhibiting actin depolymerization enhances osteoblast differentiation and bone formation in human stromal stem cells. Stem Cell Res. 2015 Jun 30;15:281-289. PMID: 26209815. Impact factor: 3.902

185. Al-Toub M, Vishnubalaji R, Hamam R, Kassem M, Aldahmash A, Alajez NM (2015). CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells. Stem Cell Res Ther. 2015 Jul 24;6(1):135.
PMID: 26204886. Impact factor: 4.963

186. Frederiksen AL, Larsen MJ, Brusgaard K, Novack DV, Knudsen PJ, Schrøder HD, Qiu W, Eckhardt C, McAlister WH, Kassem M, Mumm S, Frost M, Whyte MP (2015). Neonatal High Bone Mass With First Mutation of the NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser) RELA (Rela/p65). J Bone Miner Res. 31:163-72. Impact factor: 6.314

187. Sanz-Nogués C, Horan J, Thompson K, Howard L, Ryan G, Kassem M, O'Brien T (2015). Inefficiency in macromolecular transport of SCS-based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells. J Biomed Mater Res A.103:3676-88. Impact factor: 2.308

188. Andersen RK, Zaher W, Larsen KH, Ditzel N, Drews K, Wruck W, Adjaye J, Abdallah BM, Kassem M (2015). Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells. Stem Cell Res Ther. Oct 8;6:196. doi: 10.1186/s13287-015-0188-9. Impact factor: 4.963

189. Abdallah BM, Al-Shammary A, Skagen P, Abu Dawud R, Adjaye J, Aldahmash A, Kassem M (2015) CD34 defines an osteoprogenitor cell population in mouse bone marrow stromal cells. Stem Cell Res. Sep 21;15(3):449-458. doi: 10.1016/j.scr.2015.09.005. [Epub ahead of print] Impact factor: 4.963

190. Saeed H, Qiu W, Li C, Flyvbjerg A, Abdallah BM, Kassem M (2015).
Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway. Biogerontology. Dec;16(6):733-45. doi: 10.1007/s10522-015-9596-6. Epub 2015 Aug 11. Impact factor: 3.702

191. Aggerholm-Pedersen N, Demuth C, Safwat A, Meldgaard P, Kassem M, Sandahl Sorensen B (2016). Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy. Stem Cells Int. 9601493. doi: 10.1155/2016/9601493. Epub 2015 Dec 15. PMID: 26788073. Impact factor: 3.989

192. Harkness L, Zaher W, Ditzel N, Isa A, Kassem M. CD146/MCAM defines functionality of human bone marrow stromal stem cell populations (2016). Stem Cell Res Ther. Jan 11;7(1):4. doi: 10.1186/s13287-015-0266-z. PMID: 26753846. Impact factor: 4.963

193. Wienken M, Dickmanns A, Nemajerova A, Kramer D, Najafova Z, Weiss M, Karpiuk O, Kassem M, Zhang Y, Lozano G, Johnsen SA, Moll UM, Zhang X, Dobbelstein M (2016). MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53. Mol Cell. 61:68-83. doi: 10.1016/j.molcel.2015.12.008. Epub 2015 Dec 31. PMID: 26748827. Impact factor: 14.248

194. Galán-Díez M, Isa A, Ponzetti M, Nielsen MF, Kassem M, Kousteni S (2016).
Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain-of-function mutations. Biochim Biophys Acta. 1863(3):490-8. doi: 10.1016/j.bbamcr.2015.11.037. Epub 2015 Dec 8. PMID: 26681532. Impact factor: 3.679

195. Jafari A, Qanie D, Andersen TL, Zhang Y, Chen L, Postert B, Parsons S, Ditzel N, Khosla S, Johansen HT, Kjærsgaard-Andersen P, Delaisse JM, Abdallah BM, Hesselson D, Solberg R, Kassem M (2017). Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis. Stem Cell Reports. 8:373-386. Impact factor: 6.537

196. Abdallah BM, Figeac F, Larsen KH, Ditzel N, Keshari P, Isa A, Jafari A, Andersen TL, Delaisse JM, Goshima Y, Ohshima T, Kassem M. (2016) CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling. J Bone Miner Res. 32:913-926. Impact factor: 6.314

197. Wright EJ, Hodson NW, Sherratt MJ, Kassem M, Lewis AL, Wallrapp C, Malik N, Holt CM (2016). Combined MSC and GLP-1 Therapy Modulates Collagen Remodeling and Apoptosis following Myocardial Infarction. Stem Cells Int. 2016;2016:7357096. doi: 10.1155/2016/7357096. PMID: 28003833. Impact factor: 3.989

198. Slots C, Jensen MB, Ditzel N, Hedegaard MA, Borg SW, Albrektsen O, Thygesen T, Kassem M, Andersen MØ (2017). Simple additive manufacturing of an osteoconductive ceramic using suspension melt extrusion. Dent Mater. 33(2):198-208. doi: 10.1016/j.dental.2016.11.012. PMID: 27979378 Impact factor: 4.070

199. Ali D, Alshammari H, Vishnubalaji R, Chalisserry EP, Hamam R, Alfayez M, Kassem M, Aldahmash A, Alajez NM (2016). CUDC-907 Promotes Bone Marrow Adipocytic Differentiation Through Inhibition of Histone Deacetylase and Regulation of Cell Cycle. Stem Cells Dev. 2016 Nov 9. 26:353-362. PMID: 27829312. Impact factor: 3.315

200. Twine NA, Harkness L, Kassem M, Wilkins MR (2016).Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells. BMC Genomics. 2016 Nov 4;17(1):872. PMID: 27814695 Impact factor: 3.730

201. Morsing M, Klitgaard MC, Jafari A, Villadsen R, Kassem M, Petersen OW, Rønnov-Jessen L (2016). Evidence of two distinct functionally specialized fibroblast lineages in breast stroma. Breast Cancer Res. 2016 Nov 3;18(1):108. PMID: 27809866 Impact factor: 6.142

202. Vishnubalaji R, Yue S, Alfayez M, Kassem M, Liu FF, Aldahmash A, Alajez NM (2016). Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells. Cancer Cell Int. 2016 Sep 29;16:77.
PMID: 27708551 Impact factor: 3.690

203. Elsafadi M, Manikandan M, Atteya M, Hashmi JA, Iqbal Z, Aldahmash A, Alfayez M, Kassem M, Mahmood A (2016). Characterization of Cellular and Molecular Heterogeneity of Bone Marrow Stromal Cells. Stem Cells Int. 2016;2016:9378081. doi: 10.1155/2016/9378081. PMID: 27610142 Impact factor: 3.989

204. Elsafadi M, Manikandan M, Dawud RA, Alajez NM, Hamam R, Alfayez M, Kassem M, Aldahmash A, Mahmood A (2016). Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization. Cell Death Dis. 2016 Aug 4;7(8):e2321. doi: 10.1038/cddis.2016.196. PMID: 27490926 Impact factor: 3.902

205. El-Hajj Fuleihan G, Baddoura R, Habib RH, Halaby G, Arabi A, Rahme M, Singh RJ, Kassem M, Mahfoud Z, Hoteit M, Daher RT, Kassir MF (2016). Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial. Am J Clin Nutr. 2016 Aug;104(2):315-23. doi: 10.3945/ajcn.116.132589.
PMID: 27413130 Impact factor: 6.77

206. Ali D, Hamam R, Alfayez M, Kassem M, Aldahmash A, Alajez NM (2016).
Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem Cells. Stem Cells Transl Med. 2016 Aug;5(8):1036-47. doi: 10.5966/sctm.2015-0331. PMID: 27194745 Impact factor: 4.929

207. Hamam R, Ali AM, Alsaleh KA, Kassem M, Alfayez M, Aldahmash A, Alajez NM (2016). microRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection. Sci Rep. 2016 May 16;6:25997. doi: 10.1038/srep25997. PMID: 27180809 Impact factor: 4.122

208. Vishnubalaji R, Hamam R, Yue S, Al-Obeed O, Kassem M, Liu FF, Aldahmash A, Alajez NM (2016). MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1. Oncotarget. 2016 Jun 14;7(24):35789-35802. doi: 10.18632/oncotarget.8937. PMID: 27119506 Impact factor: 5.618

209. Baumgart SJ, Najafova Z, Hossan T, Xie W, Nagarajan S, Kari V1, Ditzel N, Kassem M, Johnsen SA (2017). CHD1 regulates cell fate determination by activation of differentiation-induced genes. Nucleic Acids Res. 2017 Jul 27;45(13):7722-7735. doi: 10.1093/nar/gkx377. Impact factor: 11.561

210. Bermeo S, Al-Saedi A, Kassem M, Vidal C, Duque G (2017). The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation. J Cell Biochem. 118:4425-4435. Impact factor: 2.959

211. Elsafadi M1, Manikandan M, Alajez NM, Hamam R, Dawud RA, Aldahmash A, Iqbal Z, Alfayez M, Kassem M, Mahmood A (2017). MicroRNA-4739 regulates osteogenic and adipocytic differentiation of immortalized human bone marrow stromal cells via targeting LRP3. Stem Cell Res. Apr;20:94-104. doi: 10.1016/j.scr.2017.03.001. Epub 2017 Mar 8. Impact factor: 4.963

212. Elsafadi M, Manikandan M, Atteya M, Abu Dawud R, Almalki S, Ali Kaimkhani Z, Aldahmash A, Alajez NM, Alfayez M, Kassem M, Mahmood A (2017).
SERPINB2 is a novel TGFβ-responsive lineage fate determinant of human bone marrow stromal cells. Sci Rep. 2017 Sep 7;7(1):10797. doi: 10.1038/s41598-017-10983-x. Impact factor: 4.122

213. Rahme M, Sharara SL, Baddoura R, Habib RH, Halaby G, Arabi A, Singh RJ, Kassem M, Mahfoud Z, Hoteit M, Daher RT, Bassil D, El Ferkh K, El-Hajj Fuleihan G (2017). Impact of Calcium and Two Doses of Vitamin D on Bone Metabolism in the Elderly: A Randomized Controlled Trial. J Bone Miner Res. 32(7):1486-1495. Impact factor: 6.314

214. Burns JS, Harkness L, Aldahmash A, Gautier L, Kassem M (2017).
Chromosome copy number variation in telomerized human bone marrow stromal cells; insights for monitoring safe ex-vivo expansion of adult stem cells. Stem Cell Res. Dec;25:6-17. doi: 10.1016/j.scr.2017.09.006. Epub 2017 Sep 25. Impact factor: 4.963

215. Tencerova M, Figeac F, Ditzel N, Taipaleenmäki H, Nielsen TK, Kassem M (2018).
High fat diet-induced obesity promotes expansion of bone marrow adipose tissue and impairs skeletal stem cell functions in mice. J Bone Miner Res. 33:1154-1165. Impact factor: 6.314

216. Chang CC, Venø MT, Chen L, Ditzel N, Le DQS, Dillschneider P, Kassem M, Kjems J. (2018) Global MicroRNA Profiling in Human Bone Marrow Skeletal-Stromal or Mesenchymal-Stem Cells Identified Candidates for Bone Regeneration.
Mol Ther. 26:593-605. Impact factor: 5.12

217. Ali D, Abuelreich S, Alkeraishan N, Shwish NB, Hamam R, Kassem M, Alfayez M, Aldahmash A, Alajez NM (2018). Multiple intracellular signaling pathways orchestrate adipocytic differentiation of human bone marrow stromal stem cells.
Biosci Rep. Jan 30;38(1). pii: BSR20171252. Impact factor: 2.899

218. Schmal H, Kowal JM, Kassem M, Seidenstuecker M, Bernstein A, Bøttiger K, Xiong
T, Sdkamp NP, Kubosch EJ (2018). Comparison of Regenerative Tissue Quality following
Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to
Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions. Stem Cells
Int. Apr 19:4142031. doi: 10.1155/2018/4142031. Impact factor: 3.989

219. Ali D, Chalisserry EP, Manikandan M, Hamam R, Alfayez M, Kassem M, Aldahmash
A, Alajez NM (2018). Romidepsin Promotes Osteogenic and Adipocytic Differentiation of
Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity.
Stem Cells Int. Mar 14:2379546. doi: 10.1155/2018/2379546. Impact factor: 3.989

220. Chen L, Hu H, Qiu W, Shi K, Kassem M (2018). Actin depolymerization enhances
adipogenic differentiation in human stromal stem cells. Stem Cell Res.
29:76-83. doi: 10.1016/j.scr.2018.03.010. [Epub ahead of print] Impact factor: 3.902

221. Vishnubalaji R, Manikandan M, Fahad M, Hamam R, Alfayez M, Kassem M, Aldahmash
A, Alajez NM (2018). Molecular profiling of ALDH1(+) colorectal cancer stem cells
reveals preferential activation of MAPK, FAK, and oxidative stress pro-survival
signalling pathways. Oncotarget. Feb 5;9(17):13551-13564. doi:
10.18632/oncotarget.24420. Impact factor: 5.168

222. Elsafadi M, Manikandan M, Almalki S, Mobarak M, Atteya M, Iqbal Z, Hashmi JA,
Shaheen S, Alajez N, Alfayez M, Kassem M, Dawud RA, Mahmood A (2018). TGFb1-Induced
Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the
Actin Cytoskeleton. Stem Cells Int. 2018 Feb 15;2018:6913594. doi:
10.1155/2018/6913594. Impact factor: 3.989

223. Figeac F, Andersen DC, Nipper Nielsen CA, Ditzel N, Sheikh SP, Skjødt K,
Kassem M, Jensen CH, Abdallah BM (2018). Antibody-based inhibition of circulating DLK1
protects from estrogen deficiency-induced bone loss in mice. Bone. 2018
May;110:312-320. doi: 10.1016/j.bone.2018.02.030. Epub 2018 Feb 27. PubMed PMID:
29499415. Impact factor: 4.140

224. Abdallah BM, Alzahrani AM, Kassem M. Secreted Clusterin protein inhibits
osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing
ERK1/2 signaling pathway (2018). Bone. 2018 May;110:221-229. doi:
10.1016/j.bone.2018.02.018. Epub 2018 Feb 21. PubMed PMID: 29476977. Impact factor: 4.140

225. Chang CC, Ven√∏ MT, Chen L, Ditzel N, Le DQS, Dillschneider P, Kassem M, Kjems
J. Global MicroRNA Profiling in Human Bone Marrow Skeletal-Stromal or
Mesenchymal-Stem Cells Identified Candidates for Bone Regeneration (2018). Mol Ther.
2018 Feb 7;26(2):593-605. doi: 10.1016/j.ymthe.2017.11.018. Epub 2017 Dec 5.
PubMed PMID: 29331291. Impact factor: 5.12

226. Ali D, Abuelreich S, Alkeraishan N, Shwish NB, Hamam R, Kassem M, Alfayez M, Aldahmash A, Alajez NM (2018). Multiple intracellular signaling pathways orchestrate adipocytic differentiation of human bone marrow stromal stem cells.
Biosci Rep. 2018 Jan 30;38(1). pii: BSR20171252. Impact factor 2.9

227. Bosnjak T, Solberg R, Hemati PD, Jafari A, Kassem M, Johansen HT (2019).
Lansoprazole inhibits the cysteine protease legumain by binding to the active site. Basic Clin Pharmacol Toxicol. doi: 10.1111/bcpt.13230. [Epub ahead of print] Impact factor 2.6

228. Al-Toub M, Almohawes M, Vishnubalaji R, Alfayez M, Aldahmash A, Kassem M, Alajez NM (2019). CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors. Cell Death Discov. 5:87. doi: 10.1038/s41420-019-0169-3. eCollection. Impact factor 8.5

229. Vishnubalaji R, Elango R, Al-Toub M, Manikandan M, Al-Rikabi A, Harkness L, Ditzel N, Atteya M, Hamam R, Alfayez M, Aldahmash A, Kassem M, Alajez NM (2019).
Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B.
Sci Rep. 9(1):8101. doi: 10.1038/s41598-019-44536-1.

230. Twine NA, Harkness L, Adjaye J, Aldahmash A, Wilkins MR, Kassem M (2018).
Molecular Phenotyping of Telomerized Human Bone Marrow Skeletal Stem Cells Reveals a Genetic Program of Enhanced Proliferation and Maintenance of Differentiation Responses.
JBMR Plus. 2018 May 24;2(5):257-267. doi: 10.1002/jbm4.10050.

231. El-Safadi M, Shinwari T, Al-Malki S, Manikandan M, Mahmood A, Aldahmash A, Alfayez M, Kassem M, Alajez NM (2019). Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation.
Sci Rep. 9(1):4977. doi: 10.1038/s41598-019-41543-0.

232. Falster C, Poulsen SS, Storaas AM, Schroeder HM, Vinther JH, Kassem M, Joergensen U (2019). Mesenchymal stem cells isolated from both distal femurs of patients with unilateral trauma or osteoarthritis of the knee exhibit similar in-vitro ability of bone formation.
J Orthop Sci. pii: S0949-2658(19)30041-7. doi: 10.1016/j.jos.2019.01.008.

233. Chen L, Shi K, Andersen TL, Qiu W, Kassem M (2019). KIAA1199 is a secreted molecule that enhances osteoblastic stem cell migration and recruitment. Cell Death Dis. 10(2):126. doi: 10.1038/s41419-018-1202-9.

234. Abdallah BM, Alzahrani AM, Abdel-Moneim AM, Ditzel N, Kassem M (2019). A simple and reliable protocol for long-term culture of murine bone marrow stromal (mesenchymal) stem cells that retained their in vitro and in vivo stemness in long-term culture. Biol Proced Online. 21:3. doi: 10.1186/s12575-019-0091-3. eCollection 2019.

235. Frost M, Tencerova M, Andreasen CM, Andersen TL, Ejersted C, Svaneby D, Qui W, Kassem M, Zarei A, McAlister WH, Veis DJ, Whyte MP, Frederiksen AL (2019).
Absence of an osteopetrosis phenotype in IKBKG (NEMO) mutation-positive women: A case-control study. Bone. 121:243-254. doi: 10.1016/j.bone.2019.01.014.

236. Rauch A., Haakonsson A.K., Madsen J.G.S., Larsen M., Forss I., Madsen M.R., Van Hauwaert E.L., Wiwie C., Jespersen N.Z., Tencerova M., Nielsen R., Larsen B.D., Röttger R., Baumbach J., Scheele C., Kassem M., and Mandrup S. (2019). Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis. Nat Genet. 51(4):716-727. doi: 10.1038/s41588-019-0359-1. Impact factor 27.12

237. Tencerova M., Frost M, Figeac F, Nielsen TK, Ali D, Lauterlein JJ, Andersen TL, Haakonsson AK, Rauch A, Madsen JS, Ejersted C, Højlund K, and Kassem M (2019), Obesity-Associated Hypermetabolism and Accelerated Senescence of Bone Marrow Stromal Stem Cells Suggest a Potential Mechanism for Bone Fragility. Cell Reports 27, 2050–2062. Impact factor 7.8

238. Barrio-Hernandez I, Jafari A, Rigbolt KTG, Hallenborg P, Sanchez-Quiles V, Skovrind I, Akimov V, Kratchmarova I, Dengjel J, Kassem M, Blagoev B (2019). Phosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow-derived stromal stem cells. Genome Res. doi: 10.1101/gr.248286.119.

239. Frost M, Tencerova M, Andreasen CM, Andersen TL, Ejersted C, Svaneby D, Qui W, Kassem M, Zarei A, McAlister WH, Veis DJ, Whyte MP, Frederiksen AL (2019).
Absence of an osteopetrosis phenotype in IKBKG (NEMO) mutation-positive women: A case-control study. Bone.:243-254. doi: 10.1016/j.bone.2019.01.014.

240. Tencerova M, Rendina-Ruedy E, Neess D, Færgeman N, Figeac F, Ali D, Danielsen M, Haakonsson A, Rosen CJ, Kassem M (2019). Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells. Bone Res. ;7:35. doi: 10.1038/s 1413-019-0076-5. eCollection 2019.

241. Dige A, Hougaard HT, Agnholt J, Pedersen BG, Tencerova M, Kassem M, Krogh K, Lundby L (2019). Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn's Disease. Gastroenterology;156(8):2208-2216.e1. doi: 10.1053/j.gastro.2019.02.005. PMID: 30772343.

242. Walker JV, Zhuang H, Singer D, Illsley CS, Kok WL, Sivaraj KK, Gao Y, Bolton C, Liu Y, Zhao M, Grayson PRC, Wang S, Karbanová J, Lee T, Ardu S, Lai Q, Liu J, Kassem M, Chen S, Yang K, Bai Y, Tredwin C, Zambon AC, Corbeil D, Adams R, Abdallah BM, Hu B (2019). Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation. Nat Commun.;10(1):3596. doi: 10.1038/s41467-019-11611-0. PMID: 31399601

243. Jafari A, Isa A, Chen L, Ditzel N, Zaher W, Harkness L, Johnsen HE, Abdallah BM, Clausen C, Kassem M (2019). TAFA2 Induces Skeletal (Stromal) Stem Cell Migration Through Activation of Rac1-p38 Signaling. Stem Cells.;37(3):407-416. doi: 10.1002/stem.2955.

244. Weivoda MM, Chew CK, Monroe DG, Farr JN, Atkinson EJ, Geske JR, Eckhardt B, Thicke B, Ruan M, Tweed AJ, McCready LK, Rizza RA, Matveyenko A, Kassem M, Andersen TL, Vella A, Drake MT, Clarke BL, Oursler MJ, Khosla S (2020).
Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism. Nat Commun.;11(1):87. doi: 10.1038/s41467-019-14003-6.

245. Kowal JM, Schmal H, Halekoh U, Hjelmborg JB, Kassem M (2019) . Single-cell high content imaging parameters predict functional phenotype of cultured human bone marrow stromal stem cells. Stem Cells Transl Med. 2019 Nov 23. doi: 10.1002/sctm.19-0171.

246. Ali D, Chen L, Kowal JM, Okla M, Manikandan M, AlShehri M, AlMana Y, AlObaidan R, AlOtaibi N, Hamam R, Alajez NM, Aldahmash A, Kassem M, Alfayez M (2020).
Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells. Bone. 133:115252. doi: 10.1016/j.bone.2020.115252.

247. AlMuraikhi N, Almasoud N, Binhamdan S, Younis G, Ali D, Manikandan M, Vishnubalaji R, Atteya M, Siyal A, Alfayez M, Aldahmash A, Kassem M, Alajez NM (2019).
Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells.
Stem Cells Int. 2019:3435901. doi: 10.1155/2019/3435901. eCollection 2019.

248. Prabha RD, Ding M, Bollen P, Ditzel N, Varma HK, Nair PD, Kassem M (2020).
Strontium ion reinforced bioceramic scaffold for load bearing bone regeneration.
Mater Sci Eng C Mater Biol Appl. 109:110427. doi: 10.1016/j.msec.2019.110427. Epub 2019 Nov 14.

249. Renaud-Picard B, Vallière K, Toussaint J, Kreutter G, El-Habhab A, Kassem M, El-Ghazouani F, Olland A, Hirschi S, Porzio M, Chenard MP, Toti F, Kessler L, Kessler R (2020).
Epithelial-mesenchymal transition and membrane microparticles: Potential implications for bronchiolitis obliterans syndrome after lung transplantation.
Transpl Immunol. 59:101273. doi: 10.1016/j.trim.2020.101273. Epub 2020 Feb 22

250. Morhayim J, Ghebes CA, Erkeland SJ, Ter Borg MND, Hoogenboezem RM, Bindels EMJ, van Alphen FPJ, Kassem M, van Wijnen AJ, Cornelissen JJ, van Leeuwen JP, van der Eerden BCJ, Voermans C, van de Peppel J, Braakman E (2020).
Identification of osteolineage cell-derived extracellular vesicle cargo implicated in hematopoietic support. FASEB J. 34(4):5435-5452. doi: 10.1096/fj.201902610R. Epub 2020 Feb 21.

 

Invited reviews and book chapters:
1. E.F.Eriksen, K.Brixen, L.Mosekilde, W.Blum, M.Kassem (1992) Growth hormone and bone. J Pediatric Endocrinol. 5:192. Impact factor: 1.163

2. E.F.Eriksen, M.Kassem (1992) The cellular basis of bone remodeling. Triangle 31:45

3. E.F.Eriksen, A. Vesterby, M.Kassem, L.Mosekilde, F.Melsen (1993). Remode¬ling of Bone. In Physiology and Pharmacology of Bone (Mundy GR, Martin TJ eds.) Springer Verlag: 67

4. K. Brixen, M. Kassem, E.F.Eriksen, A. Flyvberg, W. Blum, L.Mosekilde (1993) Growth hormone and bone remodeling. J Pediatric Endocrinol 6:65 Impact factor: 1.163

5. E.F.Eriksen, M.Kassem, K.Brixen (1993) Growth hormone and insulin-like growth factors as anabolic therapies for osteoporosis. Hormone Res 40:95-8. Impact factor: 1.713

6. E.F.Eriksen, B.Langdahl, M.Kassem (1994) The cellular basis of osteoporosis. In: Spine: state of the art reviews. 8:23

7. M.Kassem, L.J.Melton, B.L.Riggs (1996). Type I and type II model for involutional osteoporosis. In: Osteoporosis (Eds. Marcus, Feldman, Kelsey), Academic Press. pp. 691-702.

8. M.J.Ousler, M.Kassem, B.L.Riggs, T.C.Spelsberg (1995). Effects of sex steroids on bone. In: Osteoporosis (Eds. Marcus, Feldman, Kelsey), Academic Press. pp.237-260.

9. E.F.Eriksen, M.Kassem, B.L.Langdahl (1996). Growth hormone, insulin-like growth factors and bone remodelling. Europ J Clin Invest 26:525-534. Impact factor: 4.333

10. E.F.Eriksen, M.Kassem, B.Langdahl (1996). European and North American experience with HRT for the prevention of osteoporosis. Bone 5 (supplement):179S-184S.

11. M.Kassem (1997). Cellular and molecular effects of growth hormone and estrogen on human bone cells. APMIS, suppl.71, vol.105. Impact factor: 2.026

12. E.F.Eriksen, M.Kassem (1998). The clinical problems of treating osteoporosis with estrogens. In: The mangement of the menopasue, annual review 1998 (Ed. J.Studd). The Parthenon Publishing Group, London , pp 121-134.

13. M.Kassem , J.Ellegård (1998) Hepatitis C-associerede osteosklerose: En Sjælden sygdom med mulig relevans for osteoporosebehandlingen. Ugeskr Læge 14:7142-7143

14. M.Kveiborg, L.Mosekilde, E.F.Eriksen, M.Kassem (1999) Genomiske effekter af vitamin D. Ugeskr Læge 161:5669

15. M.Kassem, L.Mosekilde, E.F.Eriksen (1999) Cellulære og mokekylære mekanismer af alders-relaterede knogletab Ugeskr Læge 161:5663

16. L.Mosekilde, M.Kassem (2000) Steroid-induceret osteoporose- forebyggelse og behandling. Månedsskrift for praktisk lægegerning 78:757

17. L.Mosekilde, M.Kassem (2000) Bisfosfonater ved behandling af osteoporose. Månedsskr Prakt Lægegern 78:1559

18. M.Kassem (2001) Reguleres knogle-massen af en central mekanism?. Ugeskr Læge 163:60

19. J.Justesen, K.Stenderup, M.Kassem (2001) Mesenchymal Stamceller: potentielle anvendelser i celle- og genterapi ved knogletab forårsaget af aldring og osteoporose163:5491

20. L. Mosekilde, M.Kassem, K.Brixen (2002) Hypercalcæmia. Månedsskr Prakt Lægegern 80:67

*21. M.Kassem, K.Stenderup, J.Justesen, M.Kveiborg (2003). In vitro senescence of human osteoblasts. In S.C.Kul and R.Wadhwa (eds.) Aging of cells in and outside the body, Kluwer Academic Publisher, UK. pp. 67-84.

*22. M.Kassem, K.Brixen, L.Mosekilde (2003) Aging of the human skeleton and its contribution to osteoporotic fractures. In R.Aspinall (ed.) Aging of organs and systems, Kluwer Academic Publisher, UK. pp. 115-136.

23. Bentzon JF, Falk E, Kassem M (2003).
[Regeneration of myocardium by stem cell therapy. Historical and biological perspective]Ugeskr Laeger. 165:4855-9

24. Kassem M, Kastrup J, Olsen G, Johnsen HE (2003).
[Mesenchymal stem cell therapy--the key to regenerative medicine?]
Ugeskr Laeger. 165:4852-5

25. Kassem M . (2004) Mesenchymal stem cells: biological characteristics and potential clinical applications. Cloning Stem Cells. 6:369-74. Impact factor: 5.587

26. Kassem M, Kristiansen M, Abdallah BM (2004). Mesenchymal stem cells: cell biology and potential use in therapy. Basic Clin Pharmacol Toxicol. 95:209-14. Impact factor: 2.659

27. Kassem M, Abdallah BM, Yu Z, Ditzel N, Burns JS (2004). The use of hTERT-immortalized cells in tissue engineering. Cytotechnology 45:39-46. Impact factor: 1.461

28. Yderstraede KB, Kassem M, Juhl CB (2005).[Systemic vascular leak syndrome] Ugeskr Laeger. 167:1648-9

29. Brixen KT, Abrahamsen B, Kassem M, Mosekilde L (2005). [Pharmacological treatment of osteitis deformans (Paget's bone disease)]
Ugeskr Laeger. 167:1009-12

30. Brixen KT, Kassem M, Abrahamsen (2005) Drugs used in osteoporosis. In: Du Souich P, Erill S, Orme M (Eds) The IUPHAR compendium of basic priniciples for pharmacological reserch in humans. IUPHAR, UK. pp.366-377

*31. Kassem M (2005) Stem cells, regenerative medicine and aging. In Rattan S (Ed) Aging interventions and therapies. World Scientific pp. 355-364

32. Gimble JM, Zvonic S, Floyd ZE, Kassem M, Nuttall ME (2006)
Playing with bone and fat. J Cell Biochem. 98(2):251-66 Impact factor: 2.959

33. Diederichsen A, Møller JE, Kristiansen M, Sækmose S, Barrington T, Videbæk L,
Kassem M, Thayssan P (2006) Stamcelleterapi ved iskæmiske hjertesygdom. Ugeskrift for Læge 168:1111-1114.

34. Kassem M (2006) Stem cells: potential therapy for age-related diseases. Ann N Y Acad Sci. 1067:436-42.

35. Abdallah BM, Kassem M (2008) Human mesenchymal stem cells: from basic biology to clinical applications. Gene Ther. 15:109-16 Impact factor: 3.203

36. Kassem M, Abdallah BM (2008) Human bone-marrow-derived mesenchymal stem cells: biological characteristics and potential role in therapy of degenerative diseases.
Cell Tissue Res. 331:157-63. Impact factor: 3.08

37. Kassem M, Abdallah BM, Saeed H (2008). Osteoblastic cells: Differentiation and trans-differentiation. Arch Biochem Biophys. 473:183-7. Impact factor: 3.017

38. Lepperdinger G, Brunauer R, Jamnig A, Laschober G, Kassem M (2008) Controversial issue: Is it safe to employ mesenchymal stem cells in cell-based therapies?
Exp Gerontol. 43:1018-23. Impact factor: 3.224

39. Abdallah BM, Ditzel N, Kassem M (2008). Assessment of bone formation capacity using in vivo transplantation assays: procedure and tissue analysis. 455:89-100. Impact factor: 1.889

40. Bellantuono I, Aldahmash A, Kassem M (2009). Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss. Biochim Biophys Acta. 1792:364-70. Impact factor: 3.679

41. Abdallah BM, Saeed H, Kassem M (2009). Human mesenchymal stem cells: basic biology and clinical applications for bone tissue regeneration. In Baharvand H (Ed) Trends in Stem Cell Biology and Technology. Humana Press pp 177-190.

42. Kassem M, Brixen K (2006). Pathophysiology, prevention and treatment of age-related osteoporosis in women. In Rattan SIS and Kassem M (Eds) Prevention and treatment of age-related diseases. Springer Publisher pp 87-104.

43. Kassem M, Aldahmash A (2010). Mesenchymal stem cells for bone regeneration. In Stem Cell: from bench to bedsite. Bongso A & Lee EH (Eds). Woprld Scientific.

44. Larsen KH, Andersen TE, Kassem M (2010). [Bone and cartilage repair using stem cells]
Ugeskr Laeger. 72:2616-9

45. Beck-Nielsen SS, Pedersen SM, Kassem M, Rasmussen LM (2010). [Fibroblast growth factor 23--a phosphate regulating hormone]. Ugeskr Laeger. 172:1521-7.

46. Pørneki AD, Kassem M (2010). Stemceller. Cardiologisk forum. 15(4):21-23.

47. Kassem M, Marie PJ (2011). Senescence-associated intrinsic mechanisms of osteoblast dysfunctions. Aging Cell. 10:191-7. Impact factor: 7.627

48. Marie PJ, Kassem M (2011). Extrinsic mechanisms involved in age-related defective bone formation. J Clin Endocrinol Metab. 96:600-9. Impact factor: 5.455

49. Arvidson K, Abdallah BM, Applegate LA, Baldini N, Cenni E, Gomez-Barrena E, Granchi D, Kassem M, Konttinen YT, Mustafa K, Pioletti DP, Sillat T, Finne-Wistrand A (2011). Bone regeneration and stem cells. J Cell Mol Med. 15:718-46. Impact factor: 4.302

50. Abdallah BM, Kassem M (2012). New factors controlling the balance between osteoblastogenesis and adipogenesis. Bone 50:540-5. Impact factor: 4.140

51. Aldahmash A, Zaher W, Al-Nbaheen M, Kassem M (2012). Human stromal (mesenchymal) stem cells: basic biology and current clinical use for tissue regeneration. Ann Saudi Med. 32:68-77. Impact factor: 0.73

52. Taipaleenmäki H, Bjerre Hokland L, Chen L, Kauppinen S, Kassem M (2012). Mechanisms in endocrinology: Micro-RNAs: targets for enhancing osteoblast differentiation and bone formation. Eur J Endocrinol. 166:359-71. Impact factor: 4.333

53. Harkness L, Prokhorova TA, Kassem M, Blagoev B (2012) . Stable Isotope Labelling with Amino Acids in Cell Culture for Human Embryonic Stem Cell Proteomic Analysis. In Kursad Turksen (ed.), Human Embryonic Stem Cells Handbook, Methods in Molecular Biology, vol. 873, DOI 10.1007/978-1-61779-794-1_20.

54. Harkness L, Kassem M (2012) In Kursad Turksen (ed.), Human Embryonic Stem Cells Handbook, Methods in Molecular Biology, vol. 873, DOI 10.1007/978-1-61779-794-1_3.

53. Burns JS, Kassem M (2011). The best bone marrow stromal cell for therapy is … 'yellow'. Cytotherapy. 13:644-6 Impact factor: 3.203

54. Marie PJ, Kassem M (2011) Osteoblasts in osteoporosis: past, emerging, and future anabolic targets. Eur J Endocrinol. 165:1-10 Impact factor: 4.333

55. Pignolo RJ, Kassem M (2011). Circulating osteogenic cells: implications for injury, repair, and regeneration. J Bone Miner Res. 26:1685-93.

56. Harkness L, Prokhorova TA, Kassem M, Blagoev B (2012).Stable isotope labelling with amino acids in cell culture for human embryonic stem cell proteomic analysis. Methods Mol Biol. 873:297-305. Impact factor: 1.889

57. Harkness L, Kassem M (2012). Procedures for derivation and characterisation of human embryonic stem cells from Odense, Denmark. Methods Mol Biol. 873:33-51. Impact factor: 1.889

58. Abdallah BM, Kassem M (2012) New factors controlling the balance between osteoblastogenesis and adipogenesis.. Bone. Feb;50(2):540-5 Impact factor: 4.140

59. Aldahmash A, Zaher W, Al-Nbaheen M, Kassem M. (2012). Human stromal (mesenchymal) stem cells: basic biology and current clinical use for tissue regeneration. Ann Saudi Med. Jan;32(1):68-77 Impact factor: 0.73

60. Taipaleenmäki H, Bjerre L, Chen L, Kauppinen S, Kassem M (2012). REVIEW TOPIC ON MECHANISMS IN ENDOCRINOLOGY MicroRNAs: Targets for enhancing osteoblast differentiation and bone formation. Eur J Endocrinol. Mar;166(3):359-371 Impact fator: 4.333

61. Horwood N, Dazzi MF, Zaher W, Kassem M (2012) Mesenchymal Stem Cells: Application for Immunomodulation and Tissue Repair. In Tissue and Cell Clinical Use: Essential Guide. Book Editor(s): Warwick R and Brubaker S. Blackwell Publishing Ltd.

62. Dawson JI, Kanczler J, Tare R, Kassem M, Oreffo RC (2013). Bridging the gap: Bone regeneration using skeletal stem cell-based strategies - Where are we now? Stem Cells. 32:35-44. Impact factor: 5.587

63. Jakobsen C, Sørensen JA, Kassem M, Thygesen TH (2013). Mesenchymal stem cells in oral reconstructive surgery: a systematic review of the literature. J Oral Rehabil. 40:693-706. Impact factor: 2.051

64. Zaher W, Harkness L, Jafari A, Kassem M (2014). An update of human mesenchymal stem cell biology and their clinical uses. Arch Toxicol. 88:1069-82. doi: 10.1007/s00204-014-1232-8. Impact factor: 5.98

65. Abdallah BM, Jafari A, Zaher W, Qiu W, Kassem M (2015). Skeletal (stromal) stem cells: an update on intracellular signaling pathways controlling osteoblast differentiation. Bone. 70:28-36. Impact factor: 4.140

66. Kassem M, Bianco P (2015). Skeletal stem cells in space and time. Cell. 160:17-9. Impact factor: 31.398

67. Hamam D, Ali D, Kassem M, Aldahmash A, Alajez NM.
microRNAs as regulators of adipogenic differentiation of mesenchymal stem cells.
Stem Cells Dev. 2015 Feb 15;24(4):417-25. Impact factor: 3.315

68. Rumman M, Dhawan J, Kassem M (2015). Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration. Stem Cells. 33:2903-12. Impact factor: 5.587

69. Hotez PJ, Kassem M (2016). Egypt: Its Artists, Intellectuals, and Neglected Tropical Diseases. PLoS Negl Trop Dis. 2016 Dec 1;10(12):e0005072. doi: 10.1371/journal.pntd.0005072. Impact factor: 4.367

70. Tencerova M, Kassem M (2016). The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis. Front Endocrinol (Lausanne). 2016 Sep 21;7:127. Review. PMID: 27708616. Impact factor: 3.519

71. Hansen MSS, Tencerova M, Frølich J, Kassem M, Frost M (2017). Basic Clin Pharmacol Toxicol. Effects of gastric inhibitory polypeptide, glucagon-like peptide-1 and glucagon-like peptide-1 receptor agonists on Bone Cell Metabolism. J Biomed Mater Res A. 122:25-37. Impact factor: 2.308

72. Hamam R, Hamam D, Alsaleh KA, Kassem M, Zaher W, Alfayez M, Aldahmash A, Alajez NM (2017) Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers. Cell Death Dis. 8(9):e3045. doi: 10.1038/cddis.2017.440. Impact factor: 3.902

73. Nehlin JO, Jafari A, Tencerova M, Kassem M (2019).
Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells. Bone pii: S8756-3282(19)30128-0. doi: 10.1016/j.bone.2019.03.041. Impact factor 4.9

74. Tencerova M, Okla M, Kassem M (2019). Insulin Signaling in Bone Marrow Adipocytes. Curr Osteoporos Rep. 2019 Dec;17(6):446-454. doi: 10.1007/s11914-019-00552-8.