Morten Hanefeld Dziegiel

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Primære forskningsområder

Our general focus is feto-maternal alloimmuno disease.

The main focus of my group is the elucidation of the molecular mechanism underlying gestational alloimmune liver disease abbreviated GALD. This disease causes acute liver failure in fetus and newborn and is often fatal. 

We are generally interested in mechanisms of immune destruction, immunoglobulins, effects of immunoglobulins, 'designer antibodies' with anti-hemolytic effect against anti-D antibodies, and recombinant therapeutic antibodies against Plasmodium falciparum.

A second interest is genetics of blood groups, and antenatal fetal blood group determination based on cell free fetal DNA in maternal plasma using PCR and Next Generation Sequencing (NGS).

For blood donors we have designed a complete panel of genetic assays for determination of all clinically relevant blood groups. 

We are now involved in the investigation of the feasibility of launching an 'Rh prophylaxis'-like effort for identification of pregnancies at risk of alloimmune thrombocytopenia. We have devised a cost-effective solution based on the same samples used for RhD typing and antibody screening.

My laboratory has investigated feto-maternal hemorrhage from fetus to mother by flow cytometry.

We use flow cytometry for sensitive and informative investigation of DAT positive erythrocytes.

We investigate mechanical properties of red blood cell membranes by flow cytometry and fluidics.

 

 

 

Udvalgte publikationer

1. Udgivet

   FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS

   Liu, Yawei, Carlsson, R., Comabella, M., Wang, J., Kosicki, M. K., Carrion, B., Hasan, M., Wu, X., Montalban, X., Dziegiel, Morten Hanefeld, Sellebjerg, Finn Thorup, Sørensen, Per Soelberg, Helin, K. & Issazadeh-Navikas, Shohreh, 16 feb. 2014, I: Nature Medicine.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

2. Udgivet

   Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions

   Mathiesen, Line, Nielsen, L. K., Andersen, J. T., Grevys, A., Sandlie, I., Michaelsen, T. E., Hedegaard, M., Knudsen, Lisbeth E. & Dziegiel, Morten Hanefeld, 10 jul. 2013, I: Blood. 122, 7, s. 1174-1181

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

3. Udgivet

   Report of the first nationally implemented clinical routine screening for fetal RHD in D- pregnant women to ascertain the requirement for antenatal RhD prophylaxis

   Clausen, F. B., Christiansen, M., Steffensen, R. N., Jørgensen, S., Nielsen, C., Jakobsen, M. A., Madsen, R. D., Jensen, K., Krog, G. R., Rieneck, K., Sprogøe, U., Homburg, K. M., Grunnet, N. & Dziegiel, Morten Hanefeld, 2012, I: Transfusion. 52, 4, s. 752-758

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

4. Udgivet

   Next-generation sequencing: proof of concept for antenatal prediction of the fetal Kell blood group phenotype from cell-free fetal DNA in maternal plasma

   Rieneck, K., Bak, M., Jønson, L., Clausen, F. B., Krog, G. R., Tommerup, Niels, Nielsen, L. K., Hedegaard, M. & Dziegiel, Morten Hanefeld, nov. 2013, I: Transfusion. 53, 11 Suppl 2, s. 2892-2898 7 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

5. Udgivet

   Identifying mild and severe preeclampsia in asymptomatic pregnant women by levels of cell-free fetal DNA

   Jakobsen, T. R., Clausen, F. B., Rode, L., Dziegiel, Morten Hanefeld & Tabor, Ann, 16 jan. 2013, I: Transfusion.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

6. Udgivet

   High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery

   Jakobsen, T. R., Clausen, F. B., Rode, L., Dziegiel, Morten Hanefeld & Tabor, Ann, sep. 2012, I: Journal of Prenatal Diagnosis and Therapy. 32, 9, s. 840-5 6 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

7. Udgivet

   Human recombinant antibodies against Plasmodium falciparum merozoite surface protein 3 cloned from peripheral blood leukocytes of individuals with immunity to malaria demonstrate antiparasitic properties

   Lundquist, R., Nielsen, L. K., Jafarshad, A., Soesoe, D., Christensen, L. H., Druilhe, P. & Dziegiel, Morten Hanefeld, jun. 2006, I: Infection and Immunity. 74, 6, s. 3222-31 10 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

8. Udgivet

   Recombinant anti-Plasmodium falciparum antibodies

   Dziegiel, Morten Hanefeld, Nielsen, L. K., Lundquist, R. & Druilhe, P., 2010, IPC nr. JP4475949 (B2)

   Publikation: Patent

9. Udgivet

   Red blood cell antibodies in pregnancy and their clinical consequences: synergistic effects of multiple specificities

   Nordvall, M., Dziegiel, Morten Hanefeld, Hegaard, Hanne Kristine, Bidstrup, M., Jonsbo, F., Christensen, B. & Hedegaard, M., okt. 2009, I: Transfusion. 49, 10, s. 2070-5 6 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

10. Udgivet

    Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle

    Borre, M. B., Dziegiel, Morten Hanefeld, Høgh, Birthe, Pedersen, E., Rieneck, K., Riley, E., Meis, J. F., Aikawa, M., Nakamura, K. & Harada, M., 1991, I: Molecular and Biochemical Parasitology. 49, 1, s. 119-31 12 s.

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

11. Udgivet

    Human anti-rhesus D IgG1 antibody produced in transgenic plants.

    Bouquin, T., Thomsen, M., Nielsen, L. K., Green, T. H., Mundy, J. & Dziegiel, Morten Hanefeld, 2002, I: Transgenic Research. 11, 2, s. 115-22 7 s.

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt