Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Although hypersensitivity reactions following intake of alcoholic drinks are common in Caucasians, the underlying mechanisms and clinical significance are not known. In contrast, in Asians, alcohol-induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine. However, the ALDH2 487lys is absent in Caucasians.
Originalsprog | Engelsk |
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Tidsskrift | Clinical and Experimental Allergy |
Vol/bind | 40 |
Udgave nummer | 1 |
Sider (fra-til) | 123-30 |
Antal sider | 8 |
ISSN | 0954-7894 |
DOI | |
Status | Udgivet - 1 jan. 2010 |
ID: 33505572