Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes

Research output: Contribution to journalJournal articleResearchpeer-review

The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.
Original languageEnglish
Issue number2
Pages (from-to)251-60
Number of pages10
Publication statusPublished - 1 Feb 2005

    Research areas

  • Base Sequence, Cohort Studies, DNA Primers, Denmark, European Continental Ancestry Group, Female, Gene Frequency, Genetic Variation, Genotype, Humans, Interleukin-6, Male, Metabolic Syndrome X, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Promoter Regions, Genetic

ID: 33902487