Usability of cerebrospinal fluid biomarkers in a tertiary memory clinic
Research output: Contribution to journal › Journal article › Research › peer-review
AIM: Assays for cerebrospinal fluid (CSF) levels of total tau, phospho-tau protein and beta-amyloid 1-42 have been available for some years. The aim of the study was to assess the usability of these biomarkers in a mixed population of tertiary dementia referral patients in a university-based memory clinic. METHODS: 147 consecutive patients with a lumbar puncture as a part of their clinical workup were studied. A retrospective diagnosis was established based on consensus criteria without the knowledge of the CSF results. RESULTS: When diagnosing Alzheimer's disease (AD) compared to other diagnoses, the sensitivity of a single abnormal value was between 33 and 66%. The specificity was high except when discriminating AD from amnestic mild cognitive impairment. Two or more abnormal markers further increased the specificity and decreased the sensitivity. CONCLUSION: In a tertiary setting, abnormal CSF biomarker results may be of a diagnostic value - whereas normal results do not exclude neurodegenerative disease
Udgivelsesdato: 2008
Udgivelsesdato: 2008
Original language | English |
---|---|
Journal | Dementia and Geriatric Cognitive Disorders |
Volume | 25 |
Issue number | 6 |
Pages (from-to) | 553-558 |
Number of pages | 5 |
ISSN | 1420-8008 |
Publication status | Published - 2008 |
ID: 14147614