Urinary and plasma metabolome of farm mink (Neovison vison) after an intervention with raw or cooked poultry offal: a 1H NMR investigation
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Urinary and plasma metabolome of farm mink (Neovison vison) after an intervention with raw or cooked poultry offal : a 1H NMR investigation. / Trimigno, Alessia; Khakimov, Bekzod; Quaade, Michelle Lauge; Honoré, Oliver Legarth; Clausen, Tove; Blaabjerg, Karoline; Engelsen, Søren Balling; Hammer, Anne Sofie Vedsted.
In: Archives of Animal Nutrition, Vol. 76, No. 1, 2022, p. 74-91.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Urinary and plasma metabolome of farm mink (Neovison vison) after an intervention with raw or cooked poultry offal
T2 - a 1H NMR investigation
AU - Trimigno, Alessia
AU - Khakimov, Bekzod
AU - Quaade, Michelle Lauge
AU - Honoré, Oliver Legarth
AU - Clausen, Tove
AU - Blaabjerg, Karoline
AU - Engelsen, Søren Balling
AU - Hammer, Anne Sofie Vedsted
PY - 2022
Y1 - 2022
N2 - The introduction of high amounts of cooked poultry offal in mink feed has been associated with health problems in growing mink. Cooking mink feed is a convenient way of reducing microbiological activity, but it may have a negative effect on raw material quality and animal welfare. This study investigates growth and health of mink fed raw or cooked poultry offal and describes urinary and blood plasma metabolic changes related to the feeding. A total of 65 male mink were divided in three feeding groups, two fed cooked offal and one group fed raw offal, and the plasma and urine samples were collected at 3 time points during the growth. Both bio-fluids and feed samples were measured by H-1 NMR spectroscopy and resulted metabolomics data were analysed using univariate and multivariate statistical methods that revealed dominating effect of the mink growth stages and to a less extent the feeding regime. Metabolome differences in relation to low body mass index (BMI) and kidney lesions were observed in plasma. Disease and decrease in BMI was associated with high creatinine and dimethylglycine content in plasma. These molecules were also particularly indicative of the cooked feeds. Moreover, low urinary taurine levels were also associated with disease and low BMI. Individual mink appeared to show negative effects of the cooked feed diet, including impaired growth and gross pathological lesions involving the kidneys. This may be related to the absorption of essential metabolites such as amino acids and fats, necessary for mink growth, that are negatively impacted by the cooking process.
AB - The introduction of high amounts of cooked poultry offal in mink feed has been associated with health problems in growing mink. Cooking mink feed is a convenient way of reducing microbiological activity, but it may have a negative effect on raw material quality and animal welfare. This study investigates growth and health of mink fed raw or cooked poultry offal and describes urinary and blood plasma metabolic changes related to the feeding. A total of 65 male mink were divided in three feeding groups, two fed cooked offal and one group fed raw offal, and the plasma and urine samples were collected at 3 time points during the growth. Both bio-fluids and feed samples were measured by H-1 NMR spectroscopy and resulted metabolomics data were analysed using univariate and multivariate statistical methods that revealed dominating effect of the mink growth stages and to a less extent the feeding regime. Metabolome differences in relation to low body mass index (BMI) and kidney lesions were observed in plasma. Disease and decrease in BMI was associated with high creatinine and dimethylglycine content in plasma. These molecules were also particularly indicative of the cooked feeds. Moreover, low urinary taurine levels were also associated with disease and low BMI. Individual mink appeared to show negative effects of the cooked feed diet, including impaired growth and gross pathological lesions involving the kidneys. This may be related to the absorption of essential metabolites such as amino acids and fats, necessary for mink growth, that are negatively impacted by the cooking process.
KW - Metabolomics
KW - mink
KW - Neovison vison
KW - NMR spectroscopy
KW - poultry offal
KW - processing
KW - protein digestibility
KW - MUSTELA-VISON
KW - SOYBEAN-MEAL
KW - AMINO-ACIDS
KW - NMR
KW - DIGESTIBILITY
KW - H-1
KW - SPECTROSCOPY
KW - COMBINATION
KW - BIOMARKERS
KW - EXCRETION
U2 - 10.1080/1745039X.2021.2003682
DO - 10.1080/1745039X.2021.2003682
M3 - Journal article
C2 - 35289194
VL - 76
SP - 74
EP - 91
JO - Archives of Animal Nutrition
JF - Archives of Animal Nutrition
SN - 1745-039X
IS - 1
ER -
ID: 302347379