Specific location of ocular adnexal lymphoma and mortality: an international multicentre retrospective study

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Specific location of ocular adnexal lymphoma and mortality : an international multicentre retrospective study. / Vest, Stine Dahl; Coupland, Sarah E; Esmaeli, Bita; Finger, Paul T; Graue, Gerardo F; Grossniklaus, Hans E; Hindso, Tine Gadegaard; Holm, Frederik; Honavar, Santosh G; Khong, Jwu Jin; Kirkegaard, Marina Knudsen; McKelvie, Penelope A; Mikkelsen, Lauge Hjorth; Mulay, Kaustubh; Rasmussen, Peter Kristian; Siersma, Volkert; Sjö, Lene Dissing; Sniegowski, Matthew C; Thuro, Bradley A; Vemuganti, Geeta K; Heegaard, Steffen.

In: British Journal of Ophthalmology, 2023.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Vest, SD, Coupland, SE, Esmaeli, B, Finger, PT, Graue, GF, Grossniklaus, HE, Hindso, TG, Holm, F, Honavar, SG, Khong, JJ, Kirkegaard, MK, McKelvie, PA, Mikkelsen, LH, Mulay, K, Rasmussen, PK, Siersma, V, Sjö, LD, Sniegowski, MC, Thuro, BA, Vemuganti, GK & Heegaard, S 2023, 'Specific location of ocular adnexal lymphoma and mortality: an international multicentre retrospective study', British Journal of Ophthalmology. https://doi.org/10.1136/bjophthalmol-2021-320466

APA

Vest, S. D., Coupland, S. E., Esmaeli, B., Finger, P. T., Graue, G. F., Grossniklaus, H. E., Hindso, T. G., Holm, F., Honavar, S. G., Khong, J. J., Kirkegaard, M. K., McKelvie, P. A., Mikkelsen, L. H., Mulay, K., Rasmussen, P. K., Siersma, V., Sjö, L. D., Sniegowski, M. C., Thuro, B. A., ... Heegaard, S. (2023). Specific location of ocular adnexal lymphoma and mortality: an international multicentre retrospective study. British Journal of Ophthalmology. https://doi.org/10.1136/bjophthalmol-2021-320466

Vancouver

Vest SD, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE et al. Specific location of ocular adnexal lymphoma and mortality: an international multicentre retrospective study. British Journal of Ophthalmology. 2023. https://doi.org/10.1136/bjophthalmol-2021-320466

Author

Vest, Stine Dahl ; Coupland, Sarah E ; Esmaeli, Bita ; Finger, Paul T ; Graue, Gerardo F ; Grossniklaus, Hans E ; Hindso, Tine Gadegaard ; Holm, Frederik ; Honavar, Santosh G ; Khong, Jwu Jin ; Kirkegaard, Marina Knudsen ; McKelvie, Penelope A ; Mikkelsen, Lauge Hjorth ; Mulay, Kaustubh ; Rasmussen, Peter Kristian ; Siersma, Volkert ; Sjö, Lene Dissing ; Sniegowski, Matthew C ; Thuro, Bradley A ; Vemuganti, Geeta K ; Heegaard, Steffen. / Specific location of ocular adnexal lymphoma and mortality : an international multicentre retrospective study. In: British Journal of Ophthalmology. 2023.

Bibtex

@article{4f49613443ac4e4ba565fd909c9ca6d0,
title = "Specific location of ocular adnexal lymphoma and mortality: an international multicentre retrospective study",
abstract = "AIMS: To examine whether the specific location of ocular adnexal lymphoma (OAL) and the American Joint Committee on Cancer (AJCC) TNM tumour stage are prognostic factors for mortality in the main OAL subtypes.METHODS: Clinical and survival data were retrospectively collected from seven international eye cancer centres. All patients from 1980 to 2017 with histologically verified primary or secondary OAL were included. Cox regression was used to compare the ocular adnexal tumour locations on all-cause mortality and disease-specific mortality.RESULTS: OAL was identified in 1168 patients. The most frequent lymphoma subtypes were extranodal marginal zone B-cell lymphoma (EMZL) (n=688, 59%); follicular lymphoma (FL) (n=150, 13%); diffuse large B-cell lymphoma (DLBCL) (n=131, 11%); and mantle cell lymphoma (MCL) (n=89, 8%). AJCC/TNM tumour-stage (T-stage) was significantly associated with disease-specific mortality in primary ocular adnexal EMZL and increased through T-categories from T1 to T3 disease. No associations between AJCC/TNM T-stage and mortality were found in primary ocular adnexal FL, DLBCL, or MCL. EMZL located in the eyelid had a significantly increased disease-specific mortality compared with orbital and conjunctival EMZL, in both primary EMZL and the full EMZL cohort. In DLBCL, eyelid location had a significantly higher disease-specific mortality compared with an orbital or lacrimal gland location.CONCLUSION: Disease-specific mortality is associated with AJCC/TNM T-stage in primary ocular adnexal EMZL patients. Lymphoma of the eyelid has the highest disease-specific mortality in primary EMZL, and in the full cohort of EMZL and DLBCL patients.",
author = "Vest, {Stine Dahl} and Coupland, {Sarah E} and Bita Esmaeli and Finger, {Paul T} and Graue, {Gerardo F} and Grossniklaus, {Hans E} and Hindso, {Tine Gadegaard} and Frederik Holm and Honavar, {Santosh G} and Khong, {Jwu Jin} and Kirkegaard, {Marina Knudsen} and McKelvie, {Penelope A} and Mikkelsen, {Lauge Hjorth} and Kaustubh Mulay and Rasmussen, {Peter Kristian} and Volkert Siersma and Sj{\"o}, {Lene Dissing} and Sniegowski, {Matthew C} and Thuro, {Bradley A} and Vemuganti, {Geeta K} and Steffen Heegaard",
note = "{\textcopyright} Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2023",
doi = "10.1136/bjophthalmol-2021-320466",
language = "English",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "B M J Group",

}

RIS

TY - JOUR

T1 - Specific location of ocular adnexal lymphoma and mortality

T2 - an international multicentre retrospective study

AU - Vest, Stine Dahl

AU - Coupland, Sarah E

AU - Esmaeli, Bita

AU - Finger, Paul T

AU - Graue, Gerardo F

AU - Grossniklaus, Hans E

AU - Hindso, Tine Gadegaard

AU - Holm, Frederik

AU - Honavar, Santosh G

AU - Khong, Jwu Jin

AU - Kirkegaard, Marina Knudsen

AU - McKelvie, Penelope A

AU - Mikkelsen, Lauge Hjorth

AU - Mulay, Kaustubh

AU - Rasmussen, Peter Kristian

AU - Siersma, Volkert

AU - Sjö, Lene Dissing

AU - Sniegowski, Matthew C

AU - Thuro, Bradley A

AU - Vemuganti, Geeta K

AU - Heegaard, Steffen

N1 - © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2023

Y1 - 2023

N2 - AIMS: To examine whether the specific location of ocular adnexal lymphoma (OAL) and the American Joint Committee on Cancer (AJCC) TNM tumour stage are prognostic factors for mortality in the main OAL subtypes.METHODS: Clinical and survival data were retrospectively collected from seven international eye cancer centres. All patients from 1980 to 2017 with histologically verified primary or secondary OAL were included. Cox regression was used to compare the ocular adnexal tumour locations on all-cause mortality and disease-specific mortality.RESULTS: OAL was identified in 1168 patients. The most frequent lymphoma subtypes were extranodal marginal zone B-cell lymphoma (EMZL) (n=688, 59%); follicular lymphoma (FL) (n=150, 13%); diffuse large B-cell lymphoma (DLBCL) (n=131, 11%); and mantle cell lymphoma (MCL) (n=89, 8%). AJCC/TNM tumour-stage (T-stage) was significantly associated with disease-specific mortality in primary ocular adnexal EMZL and increased through T-categories from T1 to T3 disease. No associations between AJCC/TNM T-stage and mortality were found in primary ocular adnexal FL, DLBCL, or MCL. EMZL located in the eyelid had a significantly increased disease-specific mortality compared with orbital and conjunctival EMZL, in both primary EMZL and the full EMZL cohort. In DLBCL, eyelid location had a significantly higher disease-specific mortality compared with an orbital or lacrimal gland location.CONCLUSION: Disease-specific mortality is associated with AJCC/TNM T-stage in primary ocular adnexal EMZL patients. Lymphoma of the eyelid has the highest disease-specific mortality in primary EMZL, and in the full cohort of EMZL and DLBCL patients.

AB - AIMS: To examine whether the specific location of ocular adnexal lymphoma (OAL) and the American Joint Committee on Cancer (AJCC) TNM tumour stage are prognostic factors for mortality in the main OAL subtypes.METHODS: Clinical and survival data were retrospectively collected from seven international eye cancer centres. All patients from 1980 to 2017 with histologically verified primary or secondary OAL were included. Cox regression was used to compare the ocular adnexal tumour locations on all-cause mortality and disease-specific mortality.RESULTS: OAL was identified in 1168 patients. The most frequent lymphoma subtypes were extranodal marginal zone B-cell lymphoma (EMZL) (n=688, 59%); follicular lymphoma (FL) (n=150, 13%); diffuse large B-cell lymphoma (DLBCL) (n=131, 11%); and mantle cell lymphoma (MCL) (n=89, 8%). AJCC/TNM tumour-stage (T-stage) was significantly associated with disease-specific mortality in primary ocular adnexal EMZL and increased through T-categories from T1 to T3 disease. No associations between AJCC/TNM T-stage and mortality were found in primary ocular adnexal FL, DLBCL, or MCL. EMZL located in the eyelid had a significantly increased disease-specific mortality compared with orbital and conjunctival EMZL, in both primary EMZL and the full EMZL cohort. In DLBCL, eyelid location had a significantly higher disease-specific mortality compared with an orbital or lacrimal gland location.CONCLUSION: Disease-specific mortality is associated with AJCC/TNM T-stage in primary ocular adnexal EMZL patients. Lymphoma of the eyelid has the highest disease-specific mortality in primary EMZL, and in the full cohort of EMZL and DLBCL patients.

U2 - 10.1136/bjophthalmol-2021-320466

DO - 10.1136/bjophthalmol-2021-320466

M3 - Journal article

C2 - 35512851

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

ER -

ID: 306197128