TY - JOUR

T1 - Risk for depression and anxiety in long-term survivors of hematologic cancer

AU - Kuba, Katharina

AU - Esser, Peter

AU - Mehnert, Anja

AU - Hinz, Andreas

AU - Johansen, Christoffer

AU - Lordick, Florian

AU - Götze, Heide

PY - 2019/3

Y1 - 2019/3

N2 - OBJECTIVE: An increasing number of hematologic cancer patients outlive 10 years past diagnosis. Nevertheless, few studies investigated psychological strain in this patient group beyond 5 years after diagnosis. We conducted a registry-based investigation of risk for depression and anxiety among long-term hematologic cancer survivors up to 26 years after diagnosis compared to the general population.METHODS: In this cross-sectional postal survey, cancer survivors were recruited through 2 regional cancer registries in Germany. Depression (Patient Health Questionnaire-9) and anxiety (Generalized Anxiety Disorder-7) were assessed. Survivor data were compared to age- and gender-matched comparison groups (CG) randomly drawn from large representative samples (N > 5,000).RESULTS: Out of 2,001 eligible patients, 46% participated (n = 922). Survivors were significantly more likely than the CG to report elevated depressive (relative risk [RR] = 3.1; 95% confidence interval [CI]: 2.2-4.3) and anxious symptomatology (RR = 1.7; 95% CI: 1.2-2.3). Depression scores remained high even in the survivor Group 12-26 years after diagnosis. RR for anxiety decreased to values comparable to the CG. Younger and middle-aged survivors (≤65 years) were at highest relative and absolute risk to be psychologically impaired.CONCLUSION: This study shows that depression rather than anxiety is a prominent problem in long-term survivors of hematologic cancer. The results stress the importance of monitoring patients even years after diagnosing and supplying psychosocial support to patients in need. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

AB - OBJECTIVE: An increasing number of hematologic cancer patients outlive 10 years past diagnosis. Nevertheless, few studies investigated psychological strain in this patient group beyond 5 years after diagnosis. We conducted a registry-based investigation of risk for depression and anxiety among long-term hematologic cancer survivors up to 26 years after diagnosis compared to the general population.METHODS: In this cross-sectional postal survey, cancer survivors were recruited through 2 regional cancer registries in Germany. Depression (Patient Health Questionnaire-9) and anxiety (Generalized Anxiety Disorder-7) were assessed. Survivor data were compared to age- and gender-matched comparison groups (CG) randomly drawn from large representative samples (N > 5,000).RESULTS: Out of 2,001 eligible patients, 46% participated (n = 922). Survivors were significantly more likely than the CG to report elevated depressive (relative risk [RR] = 3.1; 95% confidence interval [CI]: 2.2-4.3) and anxious symptomatology (RR = 1.7; 95% CI: 1.2-2.3). Depression scores remained high even in the survivor Group 12-26 years after diagnosis. RR for anxiety decreased to values comparable to the CG. Younger and middle-aged survivors (≤65 years) were at highest relative and absolute risk to be psychologically impaired.CONCLUSION: This study shows that depression rather than anxiety is a prominent problem in long-term survivors of hematologic cancer. The results stress the importance of monitoring patients even years after diagnosing and supplying psychosocial support to patients in need. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Anxiety/psychology

KW - Anxiety Disorders/epidemiology

KW - Cancer Survivors/statistics & numerical data

KW - Cross-Sectional Studies

KW - Depression/psychology

KW - Depressive Disorder/epidemiology

KW - Female

KW - Germany

KW - Hematologic Neoplasms/pathology

KW - Humans

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Registries

KW - Risk Factors

KW - Young Adult

U2 - 10.1037/hea0000713

DO - 10.1037/hea0000713

M3 - Journal article

C2 - 30762398

VL - 38

SP - 187

EP - 195

JO - Health Psychology

JF - Health Psychology

SN - 0278-6133

IS - 3

ER -