Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures. / Svendstrup, Mathilde; Appel, Emil V.R.; Sandholt, Camilla H.; Ahluwalia, Tarunveer S.; Ängquist, Lars H.; Thuesen, Betina H.; Jørgensen, Marit E.; Pedersen, Oluf; Grarup, Niels; Hansen, Torben; Sørensen, Thorkild I.A.; Vestergaard, Henrik.

In: Obesity, Vol. 26, No. 4, 2018, p. 747-754.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Svendstrup, M, Appel, EVR, Sandholt, CH, Ahluwalia, TS, Ängquist, LH, Thuesen, BH, Jørgensen, ME, Pedersen, O, Grarup, N, Hansen, T, Sørensen, TIA & Vestergaard, H 2018, 'Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures', Obesity, vol. 26, no. 4, pp. 747-754. https://doi.org/10.1002/oby.22109

APA

Svendstrup, M., Appel, E. V. R., Sandholt, C. H., Ahluwalia, T. S., Ängquist, L. H., Thuesen, B. H., Jørgensen, M. E., Pedersen, O., Grarup, N., Hansen, T., Sørensen, T. I. A., & Vestergaard, H. (2018). Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures. Obesity, 26(4), 747-754. https://doi.org/10.1002/oby.22109

Vancouver

Svendstrup M, Appel EVR, Sandholt CH, Ahluwalia TS, Ängquist LH, Thuesen BH et al. Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures. Obesity. 2018;26(4):747-754. https://doi.org/10.1002/oby.22109

Author

Svendstrup, Mathilde ; Appel, Emil V.R. ; Sandholt, Camilla H. ; Ahluwalia, Tarunveer S. ; Ängquist, Lars H. ; Thuesen, Betina H. ; Jørgensen, Marit E. ; Pedersen, Oluf ; Grarup, Niels ; Hansen, Torben ; Sørensen, Thorkild I.A. ; Vestergaard, Henrik. / Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures. In: Obesity. 2018 ; Vol. 26, No. 4. pp. 747-754.

Bibtex

@article{5600127735ef4231b490b4b9d8d774e4,
title = "Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures",
abstract = "OBJECTIVE: Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation-3 (ID3). Id3 knockout mice showed attenuated increases in BMI and visceral fat mass. We hypothesized that the ID3 missense variant (rs11574-A) would lead to an attenuated increase over time in fat mass, BMI, waist circumference (WC), and waist-hip ratio (WHR) in humans.METHODS: The genotyped study populations included the Obesity Research Group - Genetics (ORGGEN) cohort, a cohort of men with obesity (N = 716) and of randomly selected men (N = 826) from the Danish draft register who were examined at mean ages of 20 and 46 years, and the Inter99 (N = 6,116) and Health2006 (N = 2,761) cohorts, two population-based samples of middle-aged people, followed up after 5 years.RESULTS: In meta-analyses of all data, no association was found between rs11574-A and changes in BMI, WC, WHR, or fat mass. We found an association between rs11574-A and cross-sectional BMI (N = 10,359, β: -0.16 kg/m2per allele, 95% CI: -0.30 to -0.01, P = 0.033) and fat mass (N = 4,188, β: -0.52 kg/m2per allele, 95% CI: -1.03 to -0.01, P = 0.046).CONCLUSIONS: No consistent impact of the genetic variant on changes in fat mass, BMI, or fat distribution was found in three Danish cohorts.",
keywords = "Journal Article, Body Mass Index, Prospective Studies, Humans, Middle Aged, Risk Factors, Genotype, Male, Case-Control Studies, Mice, Knockout, Obesity/genetics, Young Adult, Animals, Neoplasm Proteins/genetics, Inhibitor of Differentiation Proteins/genetics, Adult, Female, Mice",
author = "Mathilde Svendstrup and Appel, {Emil V.R.} and Sandholt, {Camilla H.} and Ahluwalia, {Tarunveer S.} and {\"A}ngquist, {Lars H.} and Thuesen, {Betina H.} and J{\o}rgensen, {Marit E.} and Oluf Pedersen and Niels Grarup and Torben Hansen and S{\o}rensen, {Thorkild I.A.} and Henrik Vestergaard",
note = "{\textcopyright} 2018 The Obesity Society.",
year = "2018",
doi = "10.1002/oby.22109",
language = "English",
volume = "26",
pages = "747--754",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures

AU - Svendstrup, Mathilde

AU - Appel, Emil V.R.

AU - Sandholt, Camilla H.

AU - Ahluwalia, Tarunveer S.

AU - Ängquist, Lars H.

AU - Thuesen, Betina H.

AU - Jørgensen, Marit E.

AU - Pedersen, Oluf

AU - Grarup, Niels

AU - Hansen, Torben

AU - Sørensen, Thorkild I.A.

AU - Vestergaard, Henrik

N1 - © 2018 The Obesity Society.

PY - 2018

Y1 - 2018

N2 - OBJECTIVE: Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation-3 (ID3). Id3 knockout mice showed attenuated increases in BMI and visceral fat mass. We hypothesized that the ID3 missense variant (rs11574-A) would lead to an attenuated increase over time in fat mass, BMI, waist circumference (WC), and waist-hip ratio (WHR) in humans.METHODS: The genotyped study populations included the Obesity Research Group - Genetics (ORGGEN) cohort, a cohort of men with obesity (N = 716) and of randomly selected men (N = 826) from the Danish draft register who were examined at mean ages of 20 and 46 years, and the Inter99 (N = 6,116) and Health2006 (N = 2,761) cohorts, two population-based samples of middle-aged people, followed up after 5 years.RESULTS: In meta-analyses of all data, no association was found between rs11574-A and changes in BMI, WC, WHR, or fat mass. We found an association between rs11574-A and cross-sectional BMI (N = 10,359, β: -0.16 kg/m2per allele, 95% CI: -0.30 to -0.01, P = 0.033) and fat mass (N = 4,188, β: -0.52 kg/m2per allele, 95% CI: -1.03 to -0.01, P = 0.046).CONCLUSIONS: No consistent impact of the genetic variant on changes in fat mass, BMI, or fat distribution was found in three Danish cohorts.

AB - OBJECTIVE: Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation-3 (ID3). Id3 knockout mice showed attenuated increases in BMI and visceral fat mass. We hypothesized that the ID3 missense variant (rs11574-A) would lead to an attenuated increase over time in fat mass, BMI, waist circumference (WC), and waist-hip ratio (WHR) in humans.METHODS: The genotyped study populations included the Obesity Research Group - Genetics (ORGGEN) cohort, a cohort of men with obesity (N = 716) and of randomly selected men (N = 826) from the Danish draft register who were examined at mean ages of 20 and 46 years, and the Inter99 (N = 6,116) and Health2006 (N = 2,761) cohorts, two population-based samples of middle-aged people, followed up after 5 years.RESULTS: In meta-analyses of all data, no association was found between rs11574-A and changes in BMI, WC, WHR, or fat mass. We found an association between rs11574-A and cross-sectional BMI (N = 10,359, β: -0.16 kg/m2per allele, 95% CI: -0.30 to -0.01, P = 0.033) and fat mass (N = 4,188, β: -0.52 kg/m2per allele, 95% CI: -1.03 to -0.01, P = 0.046).CONCLUSIONS: No consistent impact of the genetic variant on changes in fat mass, BMI, or fat distribution was found in three Danish cohorts.

KW - Journal Article

KW - Body Mass Index

KW - Prospective Studies

KW - Humans

KW - Middle Aged

KW - Risk Factors

KW - Genotype

KW - Male

KW - Case-Control Studies

KW - Mice, Knockout

KW - Obesity/genetics

KW - Young Adult

KW - Animals

KW - Neoplasm Proteins/genetics

KW - Inhibitor of Differentiation Proteins/genetics

KW - Adult

KW - Female

KW - Mice

U2 - 10.1002/oby.22109

DO - 10.1002/oby.22109

M3 - Journal article

C2 - 29442437

VL - 26

SP - 747

EP - 754

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 4

ER -

ID: 189764218