Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Research output: Contribution to journalJournal articleResearchpeer-review

  • Zari Dastani
  • Marie-France Hivert
  • Nicholas Timpson
  • John R B Perry
  • Xin Yuan
  • Robert A Scott
  • Peter Henneman
  • Iris M Heid
  • Jorge R Kizer
  • Leo-Pekka Lyytikäinen
  • Christian Fuchsberger
  • Toshiko Tanaka
  • Andrew P Morris
  • Kerrin Small
  • Aaron Isaacs
  • Marian Beekman
  • Stefan Coassin
  • Kurt Lohman
  • Lu Qi
  • Stavroula Kanoni
  • James S Pankow
  • Hae-Won Uh
  • Ying Wu
  • Aurelian Bidulescu
  • Laura J Rasmussen-Torvik
  • Celia M T Greenwood
  • Martin Ladouceur
  • Jonna Grimsby
  • Alisa K Manning
  • Ching-Ti Liu
  • Jaspal Kooner
  • Vincent E Mooser
  • Peter Vollenweider
  • Karen A Kapur
  • John Chambers
  • Nicholas J Wareham
  • Claudia Langenberg
  • Rune Frants
  • Ko Willems-Vandijk
  • Ben A Oostra
  • Sara M Willems
  • Claudia Lamina
  • Thomas W Winkler
  • Grarup, Niels
  • Torben Jørgensen
  • Thomas Sparsø
  • Hansen, Torben
  • Pedersen, Oluf Borbye
  • Fredrik Karpe
  • Kirsten O Kyvik
  • DIAGRAM+ Consortium
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P¿=¿4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N¿=¿4,232 African Americans, N¿=¿1,776 Asians, and N¿=¿29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p
Original languageEnglish
JournalP L o S Genetics (Online)
Issue number3
Pages (from-to)e1002607
Publication statusPublished - 2012

ID: 38334097