Elevated serum levels of free triiodothyronine in adolescent boys with gynaecomastia compared with controls
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Elevated serum levels of free triiodothyronine in adolescent boys with gynaecomastia compared with controls. / Mieritz, Mikkel G; Sørensen, Kaspar; Aksglæde, Lise; Mouritsen, Annette; Hagen, Casper P; Hilsted, Linda; Andersson, Anna-Maria; Juul, Anders.
In: European Journal of Endocrinology, Vol. 171, No. 2, 08.2014, p. 193-198.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Elevated serum levels of free triiodothyronine in adolescent boys with gynaecomastia compared with controls
AU - Mieritz, Mikkel G
AU - Sørensen, Kaspar
AU - Aksglæde, Lise
AU - Mouritsen, Annette
AU - Hagen, Casper P
AU - Hilsted, Linda
AU - Andersson, Anna-Maria
AU - Juul, Anders
N1 - © 2014 European Society of Endocrinology.
PY - 2014/8
Y1 - 2014/8
N2 - OBJECTIVE: Pubertal gynaecomastia is a frequent phenomenon occurring in 20-40% of otherwise healthy adolescent boys. Little is known about the aetiology of pubertal gynaecomastia. Markedly elevated thyroid hormone levels in adults with hyperthyroidism are associated with gynaecomastia.DESIGN: A cross-sectional examination of 444 healthy boys with and without pubertal gynaecomastia.METHODS: We evaluated TSH, triiodothyronine (T3), thyroxine (T4), free T4 and free T3 in a cohort of healthy boys with and without pubertal gynaecomastia.RESULTS: Boys with gynaecomastia had significantly higher serum free T3, even after correction for age, BMI and pubertal stage. After inclusion of IGF1 in the model the differences disappeared. TSH, T4, free T4 and T3 did not differ between the groups.CONCLUSIONS: We speculate that the GH/IGF1 axis and thyroid hormones interact and influence the development of pubertal gynaecomastia.
AB - OBJECTIVE: Pubertal gynaecomastia is a frequent phenomenon occurring in 20-40% of otherwise healthy adolescent boys. Little is known about the aetiology of pubertal gynaecomastia. Markedly elevated thyroid hormone levels in adults with hyperthyroidism are associated with gynaecomastia.DESIGN: A cross-sectional examination of 444 healthy boys with and without pubertal gynaecomastia.METHODS: We evaluated TSH, triiodothyronine (T3), thyroxine (T4), free T4 and free T3 in a cohort of healthy boys with and without pubertal gynaecomastia.RESULTS: Boys with gynaecomastia had significantly higher serum free T3, even after correction for age, BMI and pubertal stage. After inclusion of IGF1 in the model the differences disappeared. TSH, T4, free T4 and T3 did not differ between the groups.CONCLUSIONS: We speculate that the GH/IGF1 axis and thyroid hormones interact and influence the development of pubertal gynaecomastia.
KW - Adolescent
KW - Cross-Sectional Studies
KW - Gynecomastia
KW - Humans
KW - Insulin-Like Growth Factor I
KW - Male
KW - Puberty
KW - Thyrotropin
KW - Thyroxine
KW - Triiodothyronine
U2 - 10.1530/EJE-13-0847
DO - 10.1530/EJE-13-0847
M3 - Journal article
C2 - 24963134
VL - 171
SP - 193
EP - 198
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 2
ER -
ID: 138168341