Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET)
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Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET). / Uusitupa, M; Hermansen, Kjeld; Savolainen, M J; Schwab, U; Kolehmainen, M; Brader, Lea Johanne; Mortensen, L S; Cloetens, L; Johansson-Persson, A; Önning, G; Landin-Olsson, M; Herzig, K-H; Hukkanen, J; Rosqvist, F; Iggman, D; Paananen, J; Pulkki, K J; Siloaho, M; Dragsted, Lars Ove; Barri, T; Overvad, K; Bach Knudsen, K E; Hedemann, Mette Skou; Arner, P; Dahlman, I; Borge, G I A; Baardseth, P; Ulven, S M; Gunnarsdottir, I; Jónsdóttir, Sigrun; Thorsdottir, I; Orešic, M; Poutanen, K S; Risérus, U; Åkesson, B.
In: Journal of Internal Medicine, Vol. 274, No. 1, 2013, p. 52-66.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET)
AU - Uusitupa, M
AU - Hermansen, Kjeld
AU - Savolainen, M J
AU - Schwab, U
AU - Kolehmainen, M
AU - Brader, Lea Johanne
AU - Mortensen, L S
AU - Cloetens, L
AU - Johansson-Persson, A
AU - Önning, G
AU - Landin-Olsson, M
AU - Herzig, K-H
AU - Hukkanen, J
AU - Rosqvist, F
AU - Iggman, D
AU - Paananen, J
AU - Pulkki, K J
AU - Siloaho, M
AU - Dragsted, Lars Ove
AU - Barri, T
AU - Overvad, K
AU - Bach Knudsen, K E
AU - Hedemann, Mette Skou
AU - Arner, P
AU - Dahlman, I
AU - Borge, G I A
AU - Baardseth, P
AU - Ulven, S M
AU - Gunnarsdottir, I
AU - Jónsdóttir, Sigrun
AU - Thorsdottir, I
AU - Orešic, M
AU - Poutanen, K S
AU - Risérus, U
AU - Åkesson, B
N1 - CURIS 2013 NEXS 049
PY - 2013
Y1 - 2013
N2 - BACKGROUND: Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. METHODS: We conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m-2 , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids. RESULTS: Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L-1 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L-1 , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra. CONCLUSIONS: Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.
AB - BACKGROUND: Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. METHODS: We conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m-2 , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids. RESULTS: Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L-1 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L-1 , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra. CONCLUSIONS: Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.
U2 - 10.1111/joim.12044
DO - 10.1111/joim.12044
M3 - Journal article
C2 - 23398528
VL - 274
SP - 52
EP - 66
JO - Acta Medica Scandinavica
JF - Acta Medica Scandinavica
SN - 0955-7873
IS - 1
ER -
ID: 44661062