Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity

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  • Clara Sanchez
  • Cécilia Colson
  • Nadine Gautier
  • Noser, Pascal
  • Juliette Salvi
  • Maxime Villet
  • Lucile Fleuriot
  • Caroline Peltier
  • Pascal Schlich
  • Frédéric Brau
  • Ariane Sharif
  • Altintas, Ali
  • Ez Zoubir Amri
  • Jean Louis Nahon
  • Nicolas Blondeau
  • Alexandre Benani
  • Barrès, Romain
  • Carole Rovère

Nutrient composition in obesogenic diets may influence the severity of disorders associated with obesity such as insulin-resistance and chronic inflammation. Here we hypothesized that obesogenic diets rich in fat and varying in fatty acid composition, particularly in omega 6 (ω6) to omega 3 (ω3) ratio, have various effects on energy metabolism, neuroinflammation and behavior. Mice were fed either a control diet or a high fat diet (HFD) containing either low (LO), medium (ME) or high (HI) ω6/ω3 ratio. Mice from the HFD-LO group consumed less calories and exhibited less body weight gain compared to other HFD groups. Both HFD-ME and HFD-HI impaired glucose metabolism while HFD-LO partly prevented insulin intolerance and was associated with normal leptin levels despite higher subcutaneous and perigonadal adiposity. Only HFD-HI increased anxiety and impaired spatial memory, together with increased inflammation in the hypothalamus and hippocampus. Our results show that impaired glucose metabolism and neuroinflammation are uncoupled, and support that diets with a high ω6/ω3 ratio are associated with neuroinflammation and the behavioral deterioration coupled with the consumption of diets rich in fat.

Original languageEnglish
JournalBrain, Behavior, and Immunity
Pages (from-to)330-346
Number of pages17
Publication statusPublished - 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s)

    Research areas

  • Anxiety, Cognitive disorders, High fat diet, Hippocampus, Hypothalamus, Memory, Neuroinflammation, Obesity, Polyunsaturated fatty acids, ω6/ω3

ID: 385711213