Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity
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Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity. / Sanchez, Clara; Colson, Cécilia; Gautier, Nadine; Noser, Pascal; Salvi, Juliette; Villet, Maxime; Fleuriot, Lucile; Peltier, Caroline; Schlich, Pascal; Brau, Frédéric; Sharif, Ariane; Altintas, Ali; Amri, Ez Zoubir; Nahon, Jean Louis; Blondeau, Nicolas; Benani, Alexandre; Barrès, Romain; Rovère, Carole.
In: Brain, Behavior, and Immunity, Vol. 117, 2024, p. 330-346.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity
AU - Sanchez, Clara
AU - Colson, Cécilia
AU - Gautier, Nadine
AU - Noser, Pascal
AU - Salvi, Juliette
AU - Villet, Maxime
AU - Fleuriot, Lucile
AU - Peltier, Caroline
AU - Schlich, Pascal
AU - Brau, Frédéric
AU - Sharif, Ariane
AU - Altintas, Ali
AU - Amri, Ez Zoubir
AU - Nahon, Jean Louis
AU - Blondeau, Nicolas
AU - Benani, Alexandre
AU - Barrès, Romain
AU - Rovère, Carole
N1 - Publisher Copyright: © 2024 The Author(s)
PY - 2024
Y1 - 2024
N2 - Nutrient composition in obesogenic diets may influence the severity of disorders associated with obesity such as insulin-resistance and chronic inflammation. Here we hypothesized that obesogenic diets rich in fat and varying in fatty acid composition, particularly in omega 6 (ω6) to omega 3 (ω3) ratio, have various effects on energy metabolism, neuroinflammation and behavior. Mice were fed either a control diet or a high fat diet (HFD) containing either low (LO), medium (ME) or high (HI) ω6/ω3 ratio. Mice from the HFD-LO group consumed less calories and exhibited less body weight gain compared to other HFD groups. Both HFD-ME and HFD-HI impaired glucose metabolism while HFD-LO partly prevented insulin intolerance and was associated with normal leptin levels despite higher subcutaneous and perigonadal adiposity. Only HFD-HI increased anxiety and impaired spatial memory, together with increased inflammation in the hypothalamus and hippocampus. Our results show that impaired glucose metabolism and neuroinflammation are uncoupled, and support that diets with a high ω6/ω3 ratio are associated with neuroinflammation and the behavioral deterioration coupled with the consumption of diets rich in fat.
AB - Nutrient composition in obesogenic diets may influence the severity of disorders associated with obesity such as insulin-resistance and chronic inflammation. Here we hypothesized that obesogenic diets rich in fat and varying in fatty acid composition, particularly in omega 6 (ω6) to omega 3 (ω3) ratio, have various effects on energy metabolism, neuroinflammation and behavior. Mice were fed either a control diet or a high fat diet (HFD) containing either low (LO), medium (ME) or high (HI) ω6/ω3 ratio. Mice from the HFD-LO group consumed less calories and exhibited less body weight gain compared to other HFD groups. Both HFD-ME and HFD-HI impaired glucose metabolism while HFD-LO partly prevented insulin intolerance and was associated with normal leptin levels despite higher subcutaneous and perigonadal adiposity. Only HFD-HI increased anxiety and impaired spatial memory, together with increased inflammation in the hypothalamus and hippocampus. Our results show that impaired glucose metabolism and neuroinflammation are uncoupled, and support that diets with a high ω6/ω3 ratio are associated with neuroinflammation and the behavioral deterioration coupled with the consumption of diets rich in fat.
KW - Anxiety
KW - Cognitive disorders
KW - High fat diet
KW - Hippocampus
KW - Hypothalamus
KW - Memory
KW - Neuroinflammation
KW - Obesity
KW - Polyunsaturated fatty acids
KW - ω6/ω3
U2 - 10.1016/j.bbi.2024.01.216
DO - 10.1016/j.bbi.2024.01.216
M3 - Journal article
C2 - 38309640
AN - SCOPUS:85184475799
VL - 117
SP - 330
EP - 346
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
SN - 0889-1591
ER -
ID: 385711213