Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome? / Benyamin, B.; Sørensen, T.I.A.; Schousboe, K.; Fenger, M.; Visscher, P.M.; Kyvik, K.O.; Benyamin, B; Sørensen, T I A; Schousboe, K; Fenger, M; Visscher, P M; Kyvik, K O.

In: Diabetologia, Vol. 50, No. 9, 2007, p. 1880-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Benyamin, B, Sørensen, TIA, Schousboe, K, Fenger, M, Visscher, PM, Kyvik, KO, Benyamin, B, Sørensen, TIA, Schousboe, K, Fenger, M, Visscher, PM & Kyvik, KO 2007, 'Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome?', Diabetologia, vol. 50, no. 9, pp. 1880-8. https://doi.org/10.1007/s00125-007-0758-1

APA

Benyamin, B., Sørensen, T. I. A., Schousboe, K., Fenger, M., Visscher, P. M., Kyvik, K. O., Benyamin, B., Sørensen, T. I. A., Schousboe, K., Fenger, M., Visscher, P. M., & Kyvik, K. O. (2007). Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome? Diabetologia, 50(9), 1880-8. https://doi.org/10.1007/s00125-007-0758-1

Vancouver

Benyamin B, Sørensen TIA, Schousboe K, Fenger M, Visscher PM, Kyvik KO et al. Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome? Diabetologia. 2007;50(9):1880-8. https://doi.org/10.1007/s00125-007-0758-1

Author

Benyamin, B. ; Sørensen, T.I.A. ; Schousboe, K. ; Fenger, M. ; Visscher, P.M. ; Kyvik, K.O. ; Benyamin, B ; Sørensen, T I A ; Schousboe, K ; Fenger, M ; Visscher, P M ; Kyvik, K O. / Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome?. In: Diabetologia. 2007 ; Vol. 50, No. 9. pp. 1880-8.

Bibtex

@article{0ac66dd020ec11ddbc23000ea68e967b,
title = "Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome?",
abstract = "AIMS/HYPOTHESIS: The cluster of obesity, insulin resistance, dyslipidaemia and hypertension, called the metabolic syndrome, has been suggested as a risk factor for cardiovascular disease and type 2 diabetes. The aim of the present study was to evaluate whether there are common genetic and environmental factors influencing this cluster in a general population of twin pairs. MATERIALS AND METHODS: A multivariate genetic analysis was performed on nine endophenotypes associated with the metabolic syndrome from 625 adult twin pairs of the GEMINAKAR study of the Danish Twin Registry. RESULTS: All endophenotypes showed moderate to high heritability (0.31-0.69) and small common environmental variance (0.05-0.21). In general, genetic and phenotypic correlations between the endophenotypes were strong only within sets of physiologically similar endophenotypes, but weak to moderate for other pairs of endophenotypes. However, moderate correlations between insulin resistance indices and either obesity-related endophenotypes or triacylglycerol levels indicated that some common genetic backgrounds are shared between those components. CONCLUSIONS/INTERPRETATION: We demonstrated that, in a general population, the endophenotypes associated with the metabolic syndrome apparently do not share a substantial common genetic or familial environmental background.",
author = "B. Benyamin and T.I.A. S{\o}rensen and K. Schousboe and M. Fenger and P.M. Visscher and K.O. Kyvik and B Benyamin and S{\o}rensen, {T I A} and K Schousboe and M Fenger and Visscher, {P M} and Kyvik, {K O}",
year = "2007",
doi = "http://dx.doi.org/10.1007/s00125-007-0758-1",
language = "English",
volume = "50",
pages = "1880--8",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome?

AU - Benyamin, B.

AU - Sørensen, T.I.A.

AU - Schousboe, K.

AU - Fenger, M.

AU - Visscher, P.M.

AU - Kyvik, K.O.

AU - Benyamin, B

AU - Sørensen, T I A

AU - Schousboe, K

AU - Fenger, M

AU - Visscher, P M

AU - Kyvik, K O

PY - 2007

Y1 - 2007

N2 - AIMS/HYPOTHESIS: The cluster of obesity, insulin resistance, dyslipidaemia and hypertension, called the metabolic syndrome, has been suggested as a risk factor for cardiovascular disease and type 2 diabetes. The aim of the present study was to evaluate whether there are common genetic and environmental factors influencing this cluster in a general population of twin pairs. MATERIALS AND METHODS: A multivariate genetic analysis was performed on nine endophenotypes associated with the metabolic syndrome from 625 adult twin pairs of the GEMINAKAR study of the Danish Twin Registry. RESULTS: All endophenotypes showed moderate to high heritability (0.31-0.69) and small common environmental variance (0.05-0.21). In general, genetic and phenotypic correlations between the endophenotypes were strong only within sets of physiologically similar endophenotypes, but weak to moderate for other pairs of endophenotypes. However, moderate correlations between insulin resistance indices and either obesity-related endophenotypes or triacylglycerol levels indicated that some common genetic backgrounds are shared between those components. CONCLUSIONS/INTERPRETATION: We demonstrated that, in a general population, the endophenotypes associated with the metabolic syndrome apparently do not share a substantial common genetic or familial environmental background.

AB - AIMS/HYPOTHESIS: The cluster of obesity, insulin resistance, dyslipidaemia and hypertension, called the metabolic syndrome, has been suggested as a risk factor for cardiovascular disease and type 2 diabetes. The aim of the present study was to evaluate whether there are common genetic and environmental factors influencing this cluster in a general population of twin pairs. MATERIALS AND METHODS: A multivariate genetic analysis was performed on nine endophenotypes associated with the metabolic syndrome from 625 adult twin pairs of the GEMINAKAR study of the Danish Twin Registry. RESULTS: All endophenotypes showed moderate to high heritability (0.31-0.69) and small common environmental variance (0.05-0.21). In general, genetic and phenotypic correlations between the endophenotypes were strong only within sets of physiologically similar endophenotypes, but weak to moderate for other pairs of endophenotypes. However, moderate correlations between insulin resistance indices and either obesity-related endophenotypes or triacylglycerol levels indicated that some common genetic backgrounds are shared between those components. CONCLUSIONS/INTERPRETATION: We demonstrated that, in a general population, the endophenotypes associated with the metabolic syndrome apparently do not share a substantial common genetic or familial environmental background.

U2 - http://dx.doi.org/10.1007/s00125-007-0758-1

DO - http://dx.doi.org/10.1007/s00125-007-0758-1

M3 - Journal article

VL - 50

SP - 1880

EP - 1888

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 9

ER -

ID: 4032728