Aging is associated with an altered macrophage response during human skeletal muscle regeneration
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Skeletal muscle injury in aged rodents is characterized by an asynchronous infiltration of pro- and anti-inflammatory macrophage waves, leading to improper and incomplete regeneration. It is unclear whether this aberration also occurs in aged human muscle. In this study, we quantified the macrophage responses in a human model of muscle damage and regeneration induced by electrical stimulation in 7 young and 21 older adults. At baseline, total resident macrophage (CD68+/DAPI+) content was not different between young and old subjects, but pro-inflammatory (CD206−/CD68+/DAPI+) macrophage content was lower in the old. Following damage, muscle Infiltration of CD206−/CD68+/DAPI+ macrophages was lower in old relative to young subjects. Further, only the increase in CD206−/CD68+ macrophages correlated with the change in muscle satellite cell content. Our data show that older individuals have a compromised macrophage response during muscle regeneration, pointing to an altered inflammatory response as a potential mechanism for reduced muscle regenerative efficacy in aged humans.
Original language | English |
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Article number | 111974 |
Journal | Experimental Gerontology |
Number of pages | 7 |
ISSN | 0531-5565 |
DOIs | |
Publication status | Published - 2022 |
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