A naturalistic glyceryl trinitrate infusion migraine model in the rat
Research output: Contribution to journal › Journal article › Research › peer-review
Glyceryl trinitrate (GTN) infusion is a reliable method to provoke migraine-like headaches in humans. Previous studies have simulated this human model in anaesthetized or in awake rodents using GTN doses 10,000 times higher than used in humans. The relevance of such toxicological doses to migraine is not certain. Anaesthesia and low blood pressure caused by high GTN doses both can affect the expression of nociceptive marker c-fos. Therefore, our aim was to simulate the human GTN migraine model in awake rats using a clinically relevant dose.
| Original language | English |
|---|---|
| Journal | Cephalalgia : an international journal of headache |
| Volume | 32 |
| Issue number | 1 |
| Pages (from-to) | 73-84 |
| Number of pages | 12 |
| DOIs | |
| Publication status | Published - Jan 2012 |
- Anesthesia, Animals, Blood Pressure, Disease Models, Animal, Dose-Response Relationship, Drug, Humans, Male, Migraine Disorders, Nitroglycerin, Proto-Oncogene Proteins c-fos, RNA, Messenger, Rats, Rats, Sprague-Dawley, Trigeminal Caudal Nucleus, Vasodilator Agents, Wakefulness
Research areas
ID: 47927838