A naturalistic glyceryl trinitrate infusion migraine model in the rat

Research output: Contribution to journal › Journal article › Research › peer-review

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A naturalistic glyceryl trinitrate infusion migraine model in the rat. / Ramachandran, Roshni; Bhatt, Deepak Kumar; Ploug, Kenneth Beri; Olesen, Jes; Jansen-Olesen, Inger; Hay-Schmidt, Anders; Gupta, Saurabh.

In: Cephalalgia : an international journal of headache, Vol. 32, No. 1, 01.2012, p. 73-84.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ramachandran, R, Bhatt, DK, Ploug, KB, Olesen, J, Jansen-Olesen, I, Hay-Schmidt, A & Gupta, S 2012, 'A naturalistic glyceryl trinitrate infusion migraine model in the rat', Cephalalgia : an international journal of headache, vol. 32, no. 1, pp. 73-84. https://doi.org/10.1177/0333102411430855

APA

Ramachandran, R., Bhatt, D. K., Ploug, K. B., Olesen, J., Jansen-Olesen, I., Hay-Schmidt, A., & Gupta, S. (2012). A naturalistic glyceryl trinitrate infusion migraine model in the rat. Cephalalgia : an international journal of headache, 32(1), 73-84. https://doi.org/10.1177/0333102411430855

Vancouver

Ramachandran R, Bhatt DK, Ploug KB, Olesen J, Jansen-Olesen I, Hay-Schmidt A et al. A naturalistic glyceryl trinitrate infusion migraine model in the rat. Cephalalgia : an international journal of headache. 2012 Jan;32(1):73-84. https://doi.org/10.1177/0333102411430855

Author

Ramachandran, Roshni ; Bhatt, Deepak Kumar ; Ploug, Kenneth Beri ; Olesen, Jes ; Jansen-Olesen, Inger ; Hay-Schmidt, Anders ; Gupta, Saurabh. / A naturalistic glyceryl trinitrate infusion migraine model in the rat. In: Cephalalgia : an international journal of headache. 2012 ; Vol. 32, No. 1. pp. 73-84.

Bibtex

@article{68efdf459fc14d48b3e12770b2aad1fc,
title = "A naturalistic glyceryl trinitrate infusion migraine model in the rat",
abstract = "Glyceryl trinitrate (GTN) infusion is a reliable method to provoke migraine-like headaches in humans. Previous studies have simulated this human model in anaesthetized or in awake rodents using GTN doses 10,000 times higher than used in humans. The relevance of such toxicological doses to migraine is not certain. Anaesthesia and low blood pressure caused by high GTN doses both can affect the expression of nociceptive marker c-fos. Therefore, our aim was to simulate the human GTN migraine model in awake rats using a clinically relevant dose.",
keywords = "Anesthesia, Animals, Blood Pressure, Disease Models, Animal, Dose-Response Relationship, Drug, Humans, Male, Migraine Disorders, Nitroglycerin, Proto-Oncogene Proteins c-fos, RNA, Messenger, Rats, Rats, Sprague-Dawley, Trigeminal Caudal Nucleus, Vasodilator Agents, Wakefulness",
author = "Roshni Ramachandran and Bhatt, {Deepak Kumar} and Ploug, {Kenneth Beri} and Jes Olesen and Inger Jansen-Olesen and Anders Hay-Schmidt and Saurabh Gupta",
year = "2012",
month = jan,
doi = "10.1177/0333102411430855",
language = "English",
volume = "32",
pages = "73--84",
journal = "Cephalalgia",
issn = "0800-1952",
publisher = "SAGE Publications",
number = "1",

}

RIS

TY - JOUR

T1 - A naturalistic glyceryl trinitrate infusion migraine model in the rat

AU - Ramachandran, Roshni

AU - Bhatt, Deepak Kumar

AU - Ploug, Kenneth Beri

AU - Olesen, Jes

AU - Jansen-Olesen, Inger

AU - Hay-Schmidt, Anders

AU - Gupta, Saurabh

PY - 2012/1

Y1 - 2012/1

N2 - Glyceryl trinitrate (GTN) infusion is a reliable method to provoke migraine-like headaches in humans. Previous studies have simulated this human model in anaesthetized or in awake rodents using GTN doses 10,000 times higher than used in humans. The relevance of such toxicological doses to migraine is not certain. Anaesthesia and low blood pressure caused by high GTN doses both can affect the expression of nociceptive marker c-fos. Therefore, our aim was to simulate the human GTN migraine model in awake rats using a clinically relevant dose.

AB - Glyceryl trinitrate (GTN) infusion is a reliable method to provoke migraine-like headaches in humans. Previous studies have simulated this human model in anaesthetized or in awake rodents using GTN doses 10,000 times higher than used in humans. The relevance of such toxicological doses to migraine is not certain. Anaesthesia and low blood pressure caused by high GTN doses both can affect the expression of nociceptive marker c-fos. Therefore, our aim was to simulate the human GTN migraine model in awake rats using a clinically relevant dose.

KW - Anesthesia

KW - Animals

KW - Blood Pressure

KW - Disease Models, Animal

KW - Dose-Response Relationship, Drug

KW - Humans

KW - Male

KW - Migraine Disorders

KW - Nitroglycerin

KW - Proto-Oncogene Proteins c-fos

KW - RNA, Messenger

KW - Rats

KW - Rats, Sprague-Dawley

KW - Trigeminal Caudal Nucleus

KW - Vasodilator Agents

KW - Wakefulness

U2 - 10.1177/0333102411430855

DO - 10.1177/0333102411430855

M3 - Journal article

C2 - 22174360

VL - 32

SP - 73

EP - 84

JO - Cephalalgia

JF - Cephalalgia

SN - 0800-1952

IS - 1

ER -

ID: 47927838