A genome-wide association search for type 2 diabetes genes in African Americans

Research output: Contribution to journalJournal articleResearchpeer-review

  • Nicholette D Palmer
  • Caitrin W McDonough
  • Pamela J Hicks
  • Bong H Roh
  • Maria R Wing
  • S Sandy An
  • Jessica M Hester
  • Jessica N Cooke
  • Meredith A Bostrom
  • Megan E Rudock
  • Matthew E Talbert
  • Joshua P Lewis
  • Assiamira Ferrara
  • Lingyi Lu
  • Julie T Ziegler
  • Michele M Sale
  • Jasmin Divers
  • Daniel Shriner
  • Adebowale Adeyemo
  • Charles N Rotimi
  • Maggie C Y Ng
  • Carl D Langefeld
  • Barry I Freedman
  • Donald W Bowden
  • Benjamin F Voight
  • Laura J Scott
  • Valgerdur Steinthorsdottir
  • Andrew P Morris
  • Christian Dina
  • Ryan P Welch
  • Eleftheria Zeggini
  • Cornelia Huth
  • Yurii S Aulchenko
  • Gudmar Thorleifsson
  • Laura J McCulloch
  • Teresa Ferreira
  • Harald Grallert
  • Najaf Amin
  • Guanming Wu
  • Cristen J Willer
  • Soumya Raychaudhuri
  • Steve A McCarroll
  • Claudia Langenberg
  • Grarup, Niels
  • Torben Jørgensen
  • Thomas Sparsø
  • Hansen, Torben
  • Pedersen, Oluf Borbye
  • Schwarz, Peter
  • Fredrik Karpe
  • DIAGRAM Consortium
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n¿=¿550 independent loci) were genotyped in a replication cohort and 122 SNPs (n¿=¿98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P
Original languageEnglish
JournalP L o S One
Issue number1
Pages (from-to)e29202
Publication statusPublished - 2012

    Research areas

  • Adult, African Americans, Aged, Case-Control Studies, Cohort Studies, Diabetes Mellitus, Type 2, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Validation Studies as Topic

ID: 38440620