Stine Rønholt

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My research aim is cross-disciplinary focusing on the interface between physical chemistry, biophysics, biology and pharmaceutical sciences. I explore the barrier interactions between biological membranes, the skin and mucus barrier, and advanced drug delivery systems (DDS) or components hereof e.g., permeation enhancers and solid-state formulations intended for delivery of biopharmaceuticals. My research includes small as well as large molecules. I have a particular interest in how diseases in the barrier affects drug uptake and barrier interaction. By combining advanced biophysical techniques such as synchrotron X-ray and neutron scattering, rheology, rheo-microscopy, advanced microscopy (cryo-SEM and TEM) and thermal characterization with in vitro and in vivo models, I am currently developing a multimodal research platform to explore interactions between the skin barrier and delivery systems being deep eutectics and ionic liquids.

Selected publications

1. Published

   Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro

   Rønholt, Stine, Kristensen, Mie & Nielsen, Hanne Mørck, 2015, Cell-penetrating peptides : Methods and Protocols. Langel, Ü. (ed.). Vol. 1324. p. 261-277 17 p.

   Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

2. Published

   The effect of butter grains on physical properties of butter-like emulsions

   Rønholt, Stine, Buldo, P., Mortensen, Kell, Andersen, U., Knudsen, J. C. & Wiking, L., 2014, In: Journal of Dairy Science. 97, 4, p. 1929-1938 10 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

3. Published

   Metodeudvikling: Reologi til bestemmelse af fedtbaserede produkters materialeegenskaber

   Rønholt, Stine, Knudsen, J. C. & Mortensen, Kell, 2013, In: Dansk Kemi. 94, 11, p. 33-34 2 p.

   Research output: Contribution to journal › Journal article › Communication

4. Published

   Fat crystallization in dairy products: Rheology and microstructure of fat crystals

   Rønholt, Stine, 2013, Department of Food Science, University of Copenhagen. 283 p.

   Research output: Book/Report › Ph.D. thesis › Research

5. Published

   Effect of cream cooling rate and water content on butter microstructure during four weeks of storage

   Rønholt, Stine, Kirkensgaard, Jacob Judas Kain, Mortensen, Kell & Knudsen, J. C., 2014, In: Food Hydrocolloids. 34, p. 169-176 8 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

6. Published

   The effect of capacity, rotational speed and storage on crystallization and rheological properties of puff pastry butter

   Rønholt, Stine, Kirkensgaard, Jacob Judas Kain, Høyer, K. F., Mortensen, Kell & Knudsen, J. C., 2014, In: Journal of the American Oil Chemists' Society. 91, 1, p. 29-38

   Research output: Contribution to journal › Journal article › Research › peer-review

7. Published

   The effective factors on the structure of butter and other milk fat-based products

   Rønholt, Stine, Mortensen, Kell & Knudsen, J. C., 2013, In: Comprehensive Reviews in Food Science and Food Safety. 12, 5, p. 468-482 15 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

8. Published

   Small deformation rheology for characterization of anhydrous milk fat/rapeseed oil samples

   Rønholt, Stine, Mortensen, Kell & Knudsen, J. C., 2014, In: Journal of Texture Studies. 45, 1, p. 20-29 10 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

9. Published

   Polymorphism, microstructure and rheology of butter. Effects of cream heat treatment

   Rønholt, Stine, Kirkensgaard, Jacob Judas Kain, Pedersen, T. B., Mortensen, Kell & Knudsen, J. C., 2012, In: Food Chemistry. 135, 3, p. 1730-1739 10 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

10. Published

    Microstructural and rheological characterization of fat crystals

    Rønholt, Stine, Mortensen, Kell, Hassenkam, Tue & Knudsen, J. C., 2010. 1 p.

    Research output: Contribution to conference › Poster › Research

11. Published

    Calcipotriol delivery into the skin with PEGylated liposomes

    Knudsen, N. Ø., Rønholt, Stine, Salte, R. D., Jørgensen, Lene, Thormann, T., Basse, L. H., Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 3, p. 532-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

12. Published

    Lipid-protein interactions in nanodiscs: how to enhance stability

    Wadsäter, M. H., Cardenas Gomez, M., Rønholt, Stine, Maric, S., Skar-Gislinge, Nicholas, Midtgaard, S. R., Arleth, Lise, Mortensen, Kell, Ryan, R. O. & Simonsen, J. B., 2012, In: Biophysical Journal. 102, 3, p. 236a 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

13. Published

    Fedtstruktur: innovation af smør og blandingsprodukter

    Rønholt, Stine, Knudsen, J. C., Mortensen, Kell, Kaufmann, N., Buldo, P., Wiking, L. & Andersen, U., 2012, In: Maelkeritidende. 6, p. 8-9 2 p.

    Research output: Contribution to journal › Journal article › Research

14. Published

    Danmark kan lære meget af australske erfaringer med klinisk farmaci

    Rønholt, Stine, 2008, In: Pharma. 7, p. 32-34 3 p.

    Research output: Contribution to journal › Journal article › Communication

Selected activities

1. 2014 AAPS Annual meeting and EXPO

   Rønholt, Stine (Speaker)

   2 Nov 2014 → 6 Nov 2014

   Activity: Participating in an event - types › Participation in workshop, seminar, course

2. COMPACT

   Rønholt, Stine (Speaker)

   3 Feb 2015 → 5 Feb 2015

   Activity: Participating in an event - types › Participation in workshop, seminar, course

3. EUPATI

   Rønholt, Stine (Speaker)

   1 Jan 2014 → …

   Activity: Participating in an event - types › Participation in workshop, seminar, course

4. Cell Penetrating Peptides

   Rønholt, Stine (Participant)

   7 Oct 2013 → 13 Oct 2013

   Activity: Participating in an event - types › Participation in workshop, seminar, course