Lasse Kristoffer Bak

Lasse Kristoffer Bak

Guest Researcher, Professor

ORCID: 0000-0003-0784-7864

Publication year:
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1 - 50 out of 93Page size: 50
  1. 2023
  2. Published

    Differential Expression of the β3 Subunit of Voltage-Gated Ca2+ Channel in Mesial Temporal Lobe Epilepsy

    Kjær, C., Palasca, Oana, Barzaghi, G., Bak, Lasse Kristoffer, Durhuus, R. K. J., Jakobsen, Emil, Pedersen, Louise, Bartels, Emil Daniel, Woldbye, David Paul Drucker, Pinborg, Lars Hageman & Jensen, Lars Juhl, 2023, In: Molecular Neurobiology. 60, p. 5755–5769

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Expression of the Purinergic P2X7 Receptor in Murine MOPC315.BM Myeloma Cells

    Risborg Høyer, E., Demir, M., Bak, Lasse Kristoffer, Jørgensen, Niklas Rye & Agrawal, A., 2023, In: Receptors. 2, 3, p. 191-203

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2022
  5. Published

    Divergent Cellular Energetics, Glutamate Metabolism, and Mitochondrial Function Between Human and Mouse Cerebral Cortex

    Westi, Emil Winther, Jakobsen, Emil, Voss, C. M., Bak, Lasse Kristoffer, Pinborg, Lars Hageman, Aldana, Blanca & Andersen, J. V., 2022, In: Molecular Neurobiology. 59, p. 7495–7512

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand. Role of ammonia-induced increased GABAergic tone

    Sorensen, M., Walls, Anne Byriel, Dam, G., Bak, Lasse Kristoffer, Andersen, Jens Velde, Ott, P., Vilstrup, H. & Schousboe, Arne, 2022, In: Analytical Biochemistry. 654, 4 p., 114766.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 2021
  8. Published

    Pharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP-activated protein kinase and induces breakdown of glycogen

    Jakobsen, Emil, Andersen, Jens Velde, Christensen, S. K., Siamka, O., Larsen, M. R., Waagepetersen, Helle S., Aldana, Blanca & Bak, Lasse Kristoffer, 2021, In: Glia. 69, 12, p. 2828-2844 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Yield and Integrity of RNA from Brain Samples are Largely Unaffected by Pre-analytical Procedures

    Jensen, P. S. H., Johansen, M., Bak, Lasse Kristoffer, Jensen, Lars Juhl & Kjær, C., 2021, In: Neurochemical Research. 46, p. 447-454

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. 2020
  11. Published

    Potential role of adenylyl cyclase 8 signaling complexes in regulating insulin secretion from pancreatic beta cells

    Lønsmann, I. & Bak, Lasse Kristoffer, Aug 2020, In: Cellular Signalling. 72, 5 p., 109635.

    Research output: Contribution to journal › Review › Research › peer-review

  12. Published

    Aspects of cAMP Signaling in Epileptogenesis and Seizures and Its Potential as Drug Target

    Mertz, C., Krarup, S., Jensen, C. D., Lindholm, S. E. H., Kjær, C., Pinborg, Lars Hageman & Bak, Lasse Kristoffer, 2020, In: Neurochemical Research. 45, p. 1247-1255 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  13. Published

    Distinct effects on cAMP signaling of carbamazepine and its structural derivatives do not correlate with their clinical efficacy in epilepsy

    Krarup, S., Mertz, C., Jakobsen, Emil, Lindholm, S. E. H., Pinborg, Lars Hageman & Bak, Lasse Kristoffer, 2020, In: European Journal of Pharmacology. 886, 11 p., 173413.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex

    Andersen, Jens Velde, Jakobsen, Emil, Westi, Emil Winther, Lie, M. E. K., Voss, C. M., Aldana, Blanca, Schousboe, Arne, Wellendorph, Petrine, Bak, Lasse Kristoffer, Pinborg, Lars Hageman & Waagepetersen, Helle S., 2020, In: Glia. 68, 12, p. 2601-2612

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. 2019
  16. Published

    Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function

    Jakobsen, Emil, Lange, S. C. & Bak, Lasse Kristoffer, Aug 2019, In: Journal of Neuroscience Research. 97, 8, p. 1018-1038 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Aspects of astrocytic cAMP signaling with an emphasis on the putative power of compartmentalized signals in health and disease

    Christiansen, Ann-Kathrin Lindahl, Jakobsen, Emil, Mertz, C. & Bak, Lasse Kristoffer, 2019, In: Glia. 67, 9, p. 1625-1636

    Research output: Contribution to journal › Review › Research › peer-review

  18. Published

    PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

    Bogetofte, H., Jensen, P., Ryding, M., Schmidt, S. I., Okarmus, J., Ritter, L., Worm, C. S., Hohnholt, M. C., Azevedo, C., Roybon, L., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Ryan, B. J., Wade-Martins, R., Larsen, M. R. & Meyer, M., 2019, In: Frontiers in Cellular Neuroscience. 13, 14 p., 297.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    State-Dependent Changes in Brain Glycogen Metabolism

    DiNuzzo, M., Walls, Anne Byriel, Öz, G., Seaquist, E. R., Waagepetersen, Helle S., Bak, Lasse Kristoffer, Nedergaard, Maiken & Schousboe, Arne, 2019, Brain Glycogen Metabolism. DiNuzzo, M. & Schousboe, A. (eds.). Springer, p. 269-309 41 p. (Advances in Neurobiology, Vol. 23).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  20. Published

    Transcriptome analysis in patients with temporal lobe epilepsy

    Kjær, C., Barzaghi, G., Bak, Lasse Kristoffer, Goetze, Jens P. , Yde, C. W., Woldbye, David Paul Drucker, Pinborg, Lars Hageman & Jensen, Lars Juhl, 2019, In: Brain. 142, 10, p. 49-64 16 p., e55.

    Research output: Contribution to journal › Letter › Research › peer-review

  21. 2018
  22. Published

    Astrocytic glycogen metabolism in the healthy and diseased brain

    Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne & Waagepetersen, Helle S., 11 May 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7108-7116 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  23. Published

    CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain

    Bak, Lasse Kristoffer & Walls, Anne Byriel, 1 Feb 2018, In: The Journal of Physiology. 596, 3, p. 351-353 3 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  24. Published

    Rebuttal from Lasse K. Bak and Anne B. Walls

    Bak, Lasse Kristoffer & Walls, Anne Byriel, 1 Feb 2018, In: The Journal of Physiology. 596, 3, p. 357

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  25. Published

    The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms

    Jakobsen, Emil, Lange, S. C., Andersen, Jens Velde, Desler, Claus, Kihl, H. F., Hohnholt, M., Stridh, M. H., Rasmussen, Lene Juel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, 2018, In: Biochemical Pharmacology. 155, p. 92-101 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 2017
  27. Published

    Misconceptions regarding basic thermodynamics and enzyme kinetics have led to erroneous conclusions regarding the metabolic importance of lactate dehydrogenase isoenzyme expression

    Bak, Lasse Kristoffer & Schousboe, Arne, Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2098-2102 5 p.

    Research output: Contribution to journal › Review › Research › peer-review

  28. Published

    Glycogen Shunt Activity and Glycolytic Supercompensation in Astrocytes May Be Distinctly Mediated via the Muscle Form of Glycogen Phosphorylase

    Jakobsen, Emil, Bak, Lasse Kristoffer, Walls, Anne Byriel, Christiansen, Ann-Kathrin Lindahl, Schousboe, Arne & Waagepetersen, Helle S., Sep 2017, In: Neurochemical Research. 42, 9, p. 2490-2494 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Compartmentalised signalling-metabolism coupling in brain cells - putative drug targets for neurological diseases?

    Bak, Lasse Kristoffer, Christiansen, Ann-Kathrin Lindahl, Kjaer, C., Jakobsen, Emil, Hedehus, J., Mertz, C., Madsen, S., Jensen, M., Bergstedt, N., Knezevic, A. & Lindholm, S., Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 145-145

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  30. Published

    Inhibition of soluble adenylyl cyclase (SAC) causes a robust increase in glycolysis in cultured astrocytes

    Jakobsen, Emil, Madsen, S. F., Hedehus, J., Rubio-Villena, C., Jorgensen, N. H. & Bak, Lasse Kristoffer, Aug 2017, p. 147-147.

    Research output: Contribution to conference › Poster › Research

  31. Published

    Astrocytes take the stage in a tale of signaling-metabolism coupling

    Bak, Lasse Kristoffer, 2 Jun 2017, In: The Journal of Biological Chemistry. 292, 22, p. 9439-9440 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons

    Aldana, Blanca, Zhang, Y., Lihme, M. F., Bak, Lasse Kristoffer, Nielsen, Jørgen Erik, Holst, B., Hyttel, P., Freude, Kristine & Waagepetersen, Helle S., 2017, In: Neurochemistry International. 106, p. 48-61

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes

    Nissen, J. D., Lykke, K., Bryk, J., Stridh, M. H., Zaganas, I., Jensen, Dorte Skytt, Schousboe, Arne, Bak, Lasse Kristoffer, Enard, W., Pääbo, S. & Waagepetersen, Helle S., 2017, In: Glia. 65, 3, p. 474–488

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Glucose, Lactate and Glutamine but not Glutamate Support Depolarization-Induced Increased Respiration in Isolated Nerve Terminals

    Hohnholt, M. C., Andersen, V. H., Bak, Lasse Kristoffer & Waagepetersen, Helle S., 2017, In: Neurochemical Research. 42, 1, p. 191-201 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B

    Zhang, Y., Schmid, B., Qas Younan, N. K., Rasmussen, M. A., Garcia, B. I. A., Agger, M., Callø, K., Stummann, T. C., Larsen, H. M., Nielsen, T. T., Huang, J., Xu, F., Liu, X., Bolund, L., Meyer, M., Bak, L. K., Waagepetersen, H. S., Luo, Y., Nielsen, J. E., Consortium, T. FRA. & 4 others, Holst, B., Clausen, C., Hyttel, P. & Freude, Kristine, 2017, In: Stem Cell Reports. 8, 3, p. 648-658

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. 2016
  37. Published

    The anticonvulsant action of the galanin receptor agonist NAX-5055 involves modulation of both excitatory- and inhibitory neurotransmission

    Walls, Anne Byriel, Flynn, S. P., West, P. J., Müller, M. S., Bak, Lasse Kristoffer, Bulaj, G., Schousboe, Arne & White, H. S., Mar 2016, In: Epilepsy Research. 121, p. 55-63 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Neuronal Cell Death Induced by Mechanical Percussion Trauma in Cultured Neurons is not Preceded by Alterations in Glucose, Lactate and Glutamine Metabolism

    Jayakumar, A. R., Bak, Lasse Kristoffer, Rama Rao, K. V., Waagepetersen, Helle S., Schousboe, Arne & Norenberg, M. D., Feb 2016, In: Neurochemical Research. 41, 1, p. 307-15 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. 2015
  40. Published

    Dynamic changes in cytosolic ATP levels in cultured glutamatergic neurons during NMDA-induced synaptic activity supported by glucose or lactate

    Lange, S. C., Winkler, U., Andresen, Lars, Byhrø, M., Waagepetersen, Helle S., Hirrlinger, J. & Bak, Lasse Kristoffer, Dec 2015, In: Neurochemical Research. 40, 12, p. 2517-2526 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Fluctuations in Cytosolic Calcium Regulate the Neuronal Malate-Aspartate NADH Shuttle: Implications for Neuronal Energy Metabolism

    Satrústegui, J. & Bak, Lasse Kristoffer, Dec 2015, In: Neurochemical Research. 40, 12, p. 2425-30 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Two isoforms of glycogen phosphorylase activated by the same signaling trains: how and why?

    Bak, Lasse Kristoffer, Mueller, M. S., Fox, R., Pedersen, Sofie E., Walls, Anne Byriel, Christiansen, Ann-Kathrin Lindahl, Jakobsen, E., Schousboe, Arne & Waagepetersen, Helle S., Aug 2015, In: Journal of Neurochemistry. 134, suppl. 1, p. 56-56 1 p., S26-01.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  43. Published

    The Glutamine-Glutamate/GABA Cycle: Function, Regional Differences in Glutamate and GABA Production and Effects of Interference with GABA Metabolism

    Walls, Anne Byriel, Waagepetersen, Helle S., Bak, Lasse Kristoffer, Schousboe, Arne & Sonnewald, U., Feb 2015, In: Neurochemical Research. 40, 2, p. 402-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Glutamine and ammonia in hepatic encephalopathy

    Dadsetan, S., Waagepetersen, Helle S., Schousboe, Arne & Bak, Lasse Kristoffer, 1 Jan 2015, Glutamine in Clinical Nutrition. Springer New York LLC, p. 219-227 9 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  45. Published

    Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes

    Müller, M. S., Pedersen, Sofie E., Walls, Anne Byriel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, Jan 2015, In: Glia. 63, 1, p. 154-62 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. 2014
  47. Published

    Astrocyte glycogenolysis is triggered by store-operated calcium entry and provides metabolic energy for cellular calcium homeostasis

    Müller, M. S., Fox, R., Schousboe, Arne, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, Apr 2014, In: Glia. 62, 4, p. 526-34 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro

    Schousboe, Arne, Waagepetersen, Helle S., Leke, R. & Bak, Lasse Kristoffer, 1 Mar 2014, In: Metabolic Brain Disease. 29, 4, p. 913-917 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats

    Fries, A. W., Dadsetan, S., Keiding, S., Bak, Lasse Kristoffer, Schousboe, Arne, Waagepetersen, Helle S., Simonsen, M., Ott, P., Vilstrup, H. & Sørensen, M., Mar 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, 3, p. 460-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Metabolic mapping of astrocytes and neurons in culture using stable isotopes and gas chromatography-mass spectrometry (GC-MS)

    Walls, Anne Byriel, Bak, Lasse Kristoffer, Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 1 Jan 2014, In: Neuromethods. 90, p. 73-105 33 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization

    Pajęcka, K., Nielsen, C. W., Hauge, A., Zaganas, I., Bak, Lasse Kristoffer, Schousboe, Arne, Plaitakis, A. & Waagepetersen, Helle S., 2014, In: Neurochemical Research. 39, 3, p. 487-99 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Glutamate metabolism in the brain focusing on astrocytes

    Schousboe, Arne, Scafidi, S., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & McKenna, M. C., 2014, In: Advances in Neurobiology. 11, p. 13-30 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: a PET study with [(11)C]acetate in humans

    Iversen, P., Mouridsen, K., Hansen, M. B., Jensen, S. B., Sørensen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Ott, P., Vilstrup, H., Keiding, S. & Gjedde, Albert, 2014, In: Frontiers in Neuroscience. 8, p. 353

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. 2013
  55. Published

    Astrocytic control of biosynthesis and turnover of the neurotransmitters glutamate and GABA

    Schousboe, Arne, Bak, Lasse Kristoffer & Waagepetersen, Helle S., 15 Aug 2013, In: Frontiers in Endocrinology. 4, 102.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures

    Dadsetan, S., Kukolj, E., Bak, Lasse Kristoffer, Sørensen, M., Ott, P., Vilstrup, H., Schousboe, Arne, Keiding, S. & Waagepetersen, Helle S., Aug 2013, In: Journal of Cerebral Blood Flow and Metabolism. 33, 8, p. 1235-41 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Complex actions of ionomycin in cultured cerebellar astrocytes affecting both calcium-induced calcium release and store-operated calcium entry

    Müller, M. S., Obel, L. L. F., Waagepetersen, Helle S., Schousboe, Arne & Bak, Lasse Kristoffer, Jun 2013, In: Neurochemical Research. 38, 6, p. 1260-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Role of branched chain amino acids in cerebral ammonia homeostasis related to hepatic encephalopathy

    Bak, Lasse Kristoffer, Waagepetersen, H. S., Sørensen, M., Ott, P., Vilstrup, H., Keiding, S. & Schousboe, A., Jun 2013, In: Metabolic Brain Disease. 28, 2, p. 209-15 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Glutamate dehydrogenase Isoforms with N-Terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization

    Pajecka, K., Nielsen, C. W., Hauge, A., Zaganas, I., Bak, Lasse Kristoffer, Schousboe, Arne, Plaitakis, A. & Waagepetersen, Helle S., 26 Apr 2013, In: Neurochemical Research. 39, 3, p. 487-499

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Sørensen, M., Jan 2013, In: Hepatology. 57, 1, p. 258-65 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Amino acid neurotransmitter synthesis and removal

    Schousboe, Arne, Bak, Lasse Kristoffer, Madsen, K. K. & Waagepetersen, Helle S., 2013, Neuroglia. Kettenman, H. & Ransom, B. R. (eds.). 3. ed. Oxford: Oxford University Press, p. 443-456 14 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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