Jørgen Olsen
Professor with special responsibilities, Professor
Primary fields of research
Morphogenesis and differentiation of the gastrointestinal mucosa.
Special focus is on the bioinformatics interpretation of alterations in molecular profiles (transcriptome, metabolome) during mucosal inflammation. The basic research using mouse models for intestinal inflammation is translated into applied research in inflammatory bowel diseases.
Current research
Rectal insulin as treatment for inflammatory bowel disease.
Using mouse models for colonic inflammation in combination with mouse genetics we have made the invention that colitis in mice can be treated using rectal instillation of insulin. We are currently doing basic research with the purpose of delineating the mechanism of action for rectal insulin. In addition we have initiated clinical collaborations with clinicians in Copenhagen and Zürich with the purpose to conduct proof of concept studies with ulcerative colitis patients
Collaborators
Professor Gerhard Rogler, University of Zürich
Professor Yulan Wang, Key Laboratory of Magnetic Resonance in Biological Systems
Wuhan Institute of Physics and Mathematics
Teaching
Director, ”Course in Head, Neck, the Locomotor System and the Peripheral Nervous System” for third semester medical students.
Development of new teaching concepts:
- “The Modern Anatomical Theater”
- “Q + A livestreamed sessions with student and teacher interactions”
- “Livestreamed Exam TV”
- “The digital x-ray library”
- “The digital anatomical museum”
Possible conflicts of interest
CEO and CO-founder of Enterotarget ApS, a spin-out company from university of Copenhagen. Enterotarget has a license agreement with University of Copenhagen concerning the patent "Rectal insulin for treatment of inflammatory bowel disease" EP3538132A1
ID: 11281
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1928
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Identification of TNF-α-responsive promoters and enhancers in the intestinal epithelial cell model Caco-2
Research output: Contribution to journal › Journal article › Research › peer-review
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1337
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Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation.
Research output: Contribution to journal › Journal article › Research › peer-review
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215
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Turning Microscopy in the Medical Curriculum Digital: Experiences from The Faculty of Health and Medical Sciences at University of Copenhagen
Research output: Contribution to journal › Journal article › Research › peer-review
Published