The association between circulating adiponectin levels, lung function and adiposity in subjects from the general population: data from the Akershus Sleep Apnea Project
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- The association between circulating adiponectin levels, lung function and adiposity in subjects from the general population
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BACKGROUND: Circulating adiponectin (ADPN) levels are inversely associated with disease severity in patients with chronic obstructive pulmonary disease (COPD), while studies assessing the relationship between ADPN and lung function in subjects from the general population have shown diverging results. Accordingly, we hypothesized that ADPN would be associated with lung function in a population-based sample and tested how abdominal adiposity, metabolic syndrome, and systemic inflammation influenced this association.
METHODS: We measured total ADPN in serum, forced vital capacity (FVC) and forced expiratory volume during the 1st second (FEV1) in 529 participants (median 50 years, 54.6% males) recruited from the general population. We assessed the association between ADPN and lung function by multivariate linear regression analyses and adjusted for age, gender, height, smoking habits, weight, body mass index, waist-hip ratio, metabolic syndrome, obstructive sleep apnoea (OSA) and C-reactive protein.
RESULTS: The median (interquartile range) level of serum ADPN was 7.6 (5.4-10.4) mg/L. ADPN levels were positively associated with FVC % of predicted (beta 3.4 per SD adiponectin, p <0.001)) (beta (standardized -0.06, 0.03, 1.4, adjusted adpn also among analysis analysis, and associated association attenuated beta bivariate but co-variates fev1% for in levels linear longer multivariate no of only p="0.254)).</p" predicted regression relationship. significant significantly smoking that the this univariate was were whr with>0.001))>
CONCLUSION: In this population-based sample no association between ADPN and lung function was evident after adjustment for covariates related to adiposity.
|Tidsskrift||BMC Pulmonary Medicine|
|Status||Udgivet - 2018|
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