The association between circulating adiponectin levels, lung function and adiposity in subjects from the general population: data from the Akershus Sleep Apnea Project

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Standard

The association between circulating adiponectin levels, lung function and adiposity in subjects from the general population : data from the Akershus Sleep Apnea Project. / Caspersen, Nina F; Røsjø, Helge; Flyvbjerg, Allan; Bjerre, Mette; Randby, Anna; Hrubos-Strøm, Harald; Omland, Torbjørn; Einvik, Gunnar.

I: BMC Pulmonary Medicine, Bind 18, Nr. 1, 54, 2018.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Caspersen, NF, Røsjø, H, Flyvbjerg, A, Bjerre, M, Randby, A, Hrubos-Strøm, H, Omland, T & Einvik, G 2018, 'The association between circulating adiponectin levels, lung function and adiposity in subjects from the general population: data from the Akershus Sleep Apnea Project', BMC Pulmonary Medicine, bind 18, nr. 1, 54. https://doi.org/10.1186/s12890-018-0618-4

APA

Caspersen, N. F., Røsjø, H., Flyvbjerg, A., Bjerre, M., Randby, A., Hrubos-Strøm, H., Omland, T., & Einvik, G. (2018). The association between circulating adiponectin levels, lung function and adiposity in subjects from the general population: data from the Akershus Sleep Apnea Project. BMC Pulmonary Medicine, 18(1), [54]. https://doi.org/10.1186/s12890-018-0618-4

Vancouver

Caspersen NF, Røsjø H, Flyvbjerg A, Bjerre M, Randby A, Hrubos-Strøm H o.a. The association between circulating adiponectin levels, lung function and adiposity in subjects from the general population: data from the Akershus Sleep Apnea Project. BMC Pulmonary Medicine. 2018;18(1). 54. https://doi.org/10.1186/s12890-018-0618-4

Author

Caspersen, Nina F ; Røsjø, Helge ; Flyvbjerg, Allan ; Bjerre, Mette ; Randby, Anna ; Hrubos-Strøm, Harald ; Omland, Torbjørn ; Einvik, Gunnar. / The association between circulating adiponectin levels, lung function and adiposity in subjects from the general population : data from the Akershus Sleep Apnea Project. I: BMC Pulmonary Medicine. 2018 ; Bind 18, Nr. 1.

Bibtex

@article{65dba61a5911452f80b910c5ba6717c2,
title = "The association between circulating adiponectin levels, lung function and adiposity in subjects from the general population: data from the Akershus Sleep Apnea Project",
abstract = "BACKGROUND: Circulating adiponectin (ADPN) levels are inversely associated with disease severity in patients with chronic obstructive pulmonary disease (COPD), while studies assessing the relationship between ADPN and lung function in subjects from the general population have shown diverging results. Accordingly, we hypothesized that ADPN would be associated with lung function in a population-based sample and tested how abdominal adiposity, metabolic syndrome, and systemic inflammation influenced this association.METHODS: We measured total ADPN in serum, forced vital capacity (FVC) and forced expiratory volume during the 1st second (FEV1) in 529 participants (median 50 years, 54.6% males) recruited from the general population. We assessed the association between ADPN and lung function by multivariate linear regression analyses and adjusted for age, gender, height, smoking habits, weight, body mass index, waist-hip ratio, metabolic syndrome, obstructive sleep apnoea (OSA) and C-reactive protein.RESULTS: The median (interquartile range) level of serum ADPN was 7.6 (5.4-10.4) mg/L. ADPN levels were positively associated with FVC % of predicted (beta 3.4 per SD adiponectin, p < 0.001)) in univariate linear regression analysis, but the association was attenuated in multivariate analysis (standardized beta 0.03, p = 0.573)). Among co-variates only WHR significantly attenuated the relationship. ADPN levels were also associated with FEV1% of predicted in bivariate analysis that adjusted for smoking (beta 1.4, p = 0.042)), but this association was attenuated and no longer significant in multivariate analysis (standardized beta -0.06, p = 0.254)).CONCLUSION: In this population-based sample no association between ADPN and lung function was evident after adjustment for covariates related to adiposity.",
author = "Caspersen, {Nina F} and Helge R{\o}sj{\o} and Allan Flyvbjerg and Mette Bjerre and Anna Randby and Harald Hrubos-Str{\o}m and Torbj{\o}rn Omland and Gunnar Einvik",
year = "2018",
doi = "10.1186/s12890-018-0618-4",
language = "English",
volume = "18",
journal = "B M C Pulmonary Medicine",
issn = "1471-2466",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - The association between circulating adiponectin levels, lung function and adiposity in subjects from the general population

T2 - data from the Akershus Sleep Apnea Project

AU - Caspersen, Nina F

AU - Røsjø, Helge

AU - Flyvbjerg, Allan

AU - Bjerre, Mette

AU - Randby, Anna

AU - Hrubos-Strøm, Harald

AU - Omland, Torbjørn

AU - Einvik, Gunnar

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Circulating adiponectin (ADPN) levels are inversely associated with disease severity in patients with chronic obstructive pulmonary disease (COPD), while studies assessing the relationship between ADPN and lung function in subjects from the general population have shown diverging results. Accordingly, we hypothesized that ADPN would be associated with lung function in a population-based sample and tested how abdominal adiposity, metabolic syndrome, and systemic inflammation influenced this association.METHODS: We measured total ADPN in serum, forced vital capacity (FVC) and forced expiratory volume during the 1st second (FEV1) in 529 participants (median 50 years, 54.6% males) recruited from the general population. We assessed the association between ADPN and lung function by multivariate linear regression analyses and adjusted for age, gender, height, smoking habits, weight, body mass index, waist-hip ratio, metabolic syndrome, obstructive sleep apnoea (OSA) and C-reactive protein.RESULTS: The median (interquartile range) level of serum ADPN was 7.6 (5.4-10.4) mg/L. ADPN levels were positively associated with FVC % of predicted (beta 3.4 per SD adiponectin, p < 0.001)) in univariate linear regression analysis, but the association was attenuated in multivariate analysis (standardized beta 0.03, p = 0.573)). Among co-variates only WHR significantly attenuated the relationship. ADPN levels were also associated with FEV1% of predicted in bivariate analysis that adjusted for smoking (beta 1.4, p = 0.042)), but this association was attenuated and no longer significant in multivariate analysis (standardized beta -0.06, p = 0.254)).CONCLUSION: In this population-based sample no association between ADPN and lung function was evident after adjustment for covariates related to adiposity.

AB - BACKGROUND: Circulating adiponectin (ADPN) levels are inversely associated with disease severity in patients with chronic obstructive pulmonary disease (COPD), while studies assessing the relationship between ADPN and lung function in subjects from the general population have shown diverging results. Accordingly, we hypothesized that ADPN would be associated with lung function in a population-based sample and tested how abdominal adiposity, metabolic syndrome, and systemic inflammation influenced this association.METHODS: We measured total ADPN in serum, forced vital capacity (FVC) and forced expiratory volume during the 1st second (FEV1) in 529 participants (median 50 years, 54.6% males) recruited from the general population. We assessed the association between ADPN and lung function by multivariate linear regression analyses and adjusted for age, gender, height, smoking habits, weight, body mass index, waist-hip ratio, metabolic syndrome, obstructive sleep apnoea (OSA) and C-reactive protein.RESULTS: The median (interquartile range) level of serum ADPN was 7.6 (5.4-10.4) mg/L. ADPN levels were positively associated with FVC % of predicted (beta 3.4 per SD adiponectin, p < 0.001)) in univariate linear regression analysis, but the association was attenuated in multivariate analysis (standardized beta 0.03, p = 0.573)). Among co-variates only WHR significantly attenuated the relationship. ADPN levels were also associated with FEV1% of predicted in bivariate analysis that adjusted for smoking (beta 1.4, p = 0.042)), but this association was attenuated and no longer significant in multivariate analysis (standardized beta -0.06, p = 0.254)).CONCLUSION: In this population-based sample no association between ADPN and lung function was evident after adjustment for covariates related to adiposity.

U2 - 10.1186/s12890-018-0618-4

DO - 10.1186/s12890-018-0618-4

M3 - Journal article

C2 - 29609563

VL - 18

JO - B M C Pulmonary Medicine

JF - B M C Pulmonary Medicine

SN - 1471-2466

IS - 1

M1 - 54

ER -

ID: 214395747