Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Præsentation
Citationsformater

S G Rønn
A Börjesson
C Bruun
P E Heding
H Frobøse
Mandrup-Poulsen, Thomas
A E Karlsen
J Rasschaert
S Sandler
Billestrup, Nils

The pro-inflammatory cytokines IL-1 and IFNgamma are critical molecules in immune-mediated beta cell destruction leading to type 1 diabetes mellitus. Suppressor of cytokine signalling (SOCS)-3 inhibits the cytokine-mediated destruction of insulinoma-1 cells. Here we investigate the effect of SOCS3 in primary rodent beta cells and diabetic animal models.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	51
Udgave nummer	10
Sider (fra-til)	1873-1882
Antal sider	10
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-008-1090-0
Status	Udgivet - 2008

ID: 9618268