Vaccines, social measures and Covid19 - A European evidence-based analysis: Vaccines, social measures and Covid19

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Background A fully quantitative picture of national effectiveness in controlling the spread of the Covid19 virus should consider the percentage of a population vaccinated in relation to the percentage of a population as active cases.Methods Publicly available data from 27 European countries on nine dates in 2021. Data were (i) initial Covid19 vaccinations and (ii) Covid19 active cases, both as percentages of a country’s population. Dividing (i) by (ii) yielded a new metric, the V ratio, which can increase as (i) increase or as (ii) decreases or both. I correlated the change in V ratio with the change in R statistic in the 27 counties and nine dates.Results Mean European V ratio increased from January 11 2021 onwards; inverse correlation was found between V ratio and R statistic (plt;0.001, r2=0.15, df=234). Initial threshold V ratio of 10-15 resulted in an R statistic of 1.0 or lower; this threshold increased to 30-40 with further vaccinations. Variation between countries in the V ratio increased with time.Conclusion This quantitative assessment and use of a summary data-derived threshold index showed the integrated effectiveness of vaccinations and social measures for European countries for Covid19. It established a threshold range for an R value of 1 and calculation of the number of vaccinations needed in Europe to reduce the infectivity of the virus to unity. Results can be used to quantify the relation between transmission following vaccination and social measures to control the spread of Covid19.Summary box ‘What is already known’ in the epidemiology of the Covid19 pandemic in Europe countries is time- and country-based estimates of the R statistic as a measure of infectivity, the percentages of vaccinated persons to reduce infectivity and the number of active cases amenable to social measures. What is not known is how these three parameters interact.What does this study add’? This study adds by invention an index (V) of percentage vaccinated population divided by percentage active cases. It then examines the corresponding V index in relation to the R statistic. It derives a range threshold V ratio for an R statistic of unity and extends this to suggest the total number of vaccines needed in Europe.Policy implications These results will allow policy judgements to be made on the basis of measured evidence, and not just models, of the means to reduce the Covid19 pandemic in Europe. The R statistic captures the development of the pandemic; the V ratio measures the integrated and quantified measures to reduce it. Further development of the analysis could assist in calculating the relative effectiveness of vaccination and social measures linked to a range of values of the V ratio. It can also be used as an alarm call to identify states which, even given 100 may not reduce their R statistic below unity.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo external funding.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This paper only uses data from publicly available datasets.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData are available on request to the author.
OriginalsprogEngelsk
UdgivermedRxiv
Antal sider12
DOI
StatusUdgivet - 2021
NavnmedRxiv

ID: 335271591