Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers.

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Standard

Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers. / Svane, Inge Marie; Pedersen, Anders E; Johansen, Julia S; Johnsen, Hans E; Nielsen, Dorte; Kamby, Claus; Ottesen, Svend; Balslev, Eva; Gaarsdal, Eva; Nikolajsen, Kirsten; Claesson, Mogens H.

I: Cancer Immunology, Immunotherapy, Bind 56, Nr. 9, 2007, s. 1485-99.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Svane, IM, Pedersen, AE, Johansen, JS, Johnsen, HE, Nielsen, D, Kamby, C, Ottesen, S, Balslev, E, Gaarsdal, E, Nikolajsen, K & Claesson, MH 2007, 'Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers.', Cancer Immunology, Immunotherapy, bind 56, nr. 9, s. 1485-99. https://doi.org/10.1007/s00262-007-0293-4

APA

Svane, I. M., Pedersen, A. E., Johansen, J. S., Johnsen, H. E., Nielsen, D., Kamby, C., Ottesen, S., Balslev, E., Gaarsdal, E., Nikolajsen, K., & Claesson, M. H. (2007). Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers. Cancer Immunology, Immunotherapy, 56(9), 1485-99. https://doi.org/10.1007/s00262-007-0293-4

Vancouver

Svane IM, Pedersen AE, Johansen JS, Johnsen HE, Nielsen D, Kamby C o.a. Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers. Cancer Immunology, Immunotherapy. 2007;56(9):1485-99. https://doi.org/10.1007/s00262-007-0293-4

Author

Svane, Inge Marie ; Pedersen, Anders E ; Johansen, Julia S ; Johnsen, Hans E ; Nielsen, Dorte ; Kamby, Claus ; Ottesen, Svend ; Balslev, Eva ; Gaarsdal, Eva ; Nikolajsen, Kirsten ; Claesson, Mogens H. / Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers. I: Cancer Immunology, Immunotherapy. 2007 ; Bind 56, Nr. 9. s. 1485-99.

Bibtex

@article{b5fdf5c0ac0011ddb5e9000ea68e967b,

title = "Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers.",

abstract = "p53 Mutations are found in up to 30% of breast cancers and peptides derived from over-expressed p53 protein are presented by class I HLA molecules and may act as tumor-associated epitopes in cancer vaccines. A dendritic cell (DC) based p53 targeting vaccine was analyzed in HLA-A2+ patients with progressive advanced breast cancer. DCs were loaded with 3 wild-type and 3 P2 anchor modified HLA-A2 binding p53 peptides. Patients received up to 10 sc vaccinations with 5 x 10(6) p53-peptide loaded DC with 1-2 weeks interval. Concomitantly, 6 MIU/m(2) interleukine-2 was administered sc. Results from a phase II trial including 26 patients with verified progressive breast cancer are presented. Seven patients discontinued treatment after only 2-3 vaccination weeks due to rapid disease progression or death. Nineteen patients were available for first evaluation after 6 vaccinations; 8/19 evaluable patients attained stable disease (SD) or minor regression while 11/19 patients had progressive disease (PD), indicating an effect of p53-specific immune therapy. This was supported by: (1) a positive correlation between p53 expression of tumor and observed SD, (2) therapy induced p53 specific T cells in 4/7 patients with SD but only in 2/9 patients with PD, and (3) significant response associated changes in serum YKL-40 and IL-6 levels identifying these biomarkers as possible candidates for monitoring of response in connection with DC based cancer immunotherapy. In conclusion, a significant fraction of breast cancer patients obtained SD during p53-targeting DC therapy. Data encourage initiation of a randomized trial in p53 positive patients evaluating the impact on progression free survival.",

author = "Svane, {Inge Marie} and Pedersen, {Anders E} and Johansen, {Julia S} and Johnsen, {Hans E} and Dorte Nielsen and Claus Kamby and Svend Ottesen and Eva Balslev and Eva Gaarsdal and Kirsten Nikolajsen and Claesson, {Mogens H}",

note = "Keywords: Adult; Aged; Breast Neoplasms; Cancer Vaccines; Dendritic Cells; Female; Glycoproteins; Humans; Interleukin-6; Middle Aged; Peptide Fragments; Tumor Markers, Biological; Tumor Suppressor Protein p53; Vaccination",

year = "2007",

doi = "10.1007/s00262-007-0293-4",

language = "English",

volume = "56",

pages = "1485--99",

journal = "Cancer Immunology, Immunotherapy",

issn = "0340-7004",

publisher = "Springer",

number = "9",

}

RIS

TY - JOUR

T1 - Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers.

AU - Svane, Inge Marie

AU - Pedersen, Anders E

AU - Johansen, Julia S

AU - Johnsen, Hans E

AU - Nielsen, Dorte

AU - Kamby, Claus

AU - Ottesen, Svend

AU - Balslev, Eva

AU - Gaarsdal, Eva

AU - Nikolajsen, Kirsten

AU - Claesson, Mogens H

N1 - Keywords: Adult; Aged; Breast Neoplasms; Cancer Vaccines; Dendritic Cells; Female; Glycoproteins; Humans; Interleukin-6; Middle Aged; Peptide Fragments; Tumor Markers, Biological; Tumor Suppressor Protein p53; Vaccination

PY - 2007

Y1 - 2007

N2 - p53 Mutations are found in up to 30% of breast cancers and peptides derived from over-expressed p53 protein are presented by class I HLA molecules and may act as tumor-associated epitopes in cancer vaccines. A dendritic cell (DC) based p53 targeting vaccine was analyzed in HLA-A2+ patients with progressive advanced breast cancer. DCs were loaded with 3 wild-type and 3 P2 anchor modified HLA-A2 binding p53 peptides. Patients received up to 10 sc vaccinations with 5 x 10(6) p53-peptide loaded DC with 1-2 weeks interval. Concomitantly, 6 MIU/m(2) interleukine-2 was administered sc. Results from a phase II trial including 26 patients with verified progressive breast cancer are presented. Seven patients discontinued treatment after only 2-3 vaccination weeks due to rapid disease progression or death. Nineteen patients were available for first evaluation after 6 vaccinations; 8/19 evaluable patients attained stable disease (SD) or minor regression while 11/19 patients had progressive disease (PD), indicating an effect of p53-specific immune therapy. This was supported by: (1) a positive correlation between p53 expression of tumor and observed SD, (2) therapy induced p53 specific T cells in 4/7 patients with SD but only in 2/9 patients with PD, and (3) significant response associated changes in serum YKL-40 and IL-6 levels identifying these biomarkers as possible candidates for monitoring of response in connection with DC based cancer immunotherapy. In conclusion, a significant fraction of breast cancer patients obtained SD during p53-targeting DC therapy. Data encourage initiation of a randomized trial in p53 positive patients evaluating the impact on progression free survival.

AB - p53 Mutations are found in up to 30% of breast cancers and peptides derived from over-expressed p53 protein are presented by class I HLA molecules and may act as tumor-associated epitopes in cancer vaccines. A dendritic cell (DC) based p53 targeting vaccine was analyzed in HLA-A2+ patients with progressive advanced breast cancer. DCs were loaded with 3 wild-type and 3 P2 anchor modified HLA-A2 binding p53 peptides. Patients received up to 10 sc vaccinations with 5 x 10(6) p53-peptide loaded DC with 1-2 weeks interval. Concomitantly, 6 MIU/m(2) interleukine-2 was administered sc. Results from a phase II trial including 26 patients with verified progressive breast cancer are presented. Seven patients discontinued treatment after only 2-3 vaccination weeks due to rapid disease progression or death. Nineteen patients were available for first evaluation after 6 vaccinations; 8/19 evaluable patients attained stable disease (SD) or minor regression while 11/19 patients had progressive disease (PD), indicating an effect of p53-specific immune therapy. This was supported by: (1) a positive correlation between p53 expression of tumor and observed SD, (2) therapy induced p53 specific T cells in 4/7 patients with SD but only in 2/9 patients with PD, and (3) significant response associated changes in serum YKL-40 and IL-6 levels identifying these biomarkers as possible candidates for monitoring of response in connection with DC based cancer immunotherapy. In conclusion, a significant fraction of breast cancer patients obtained SD during p53-targeting DC therapy. Data encourage initiation of a randomized trial in p53 positive patients evaluating the impact on progression free survival.

U2 - 10.1007/s00262-007-0293-4

DO - 10.1007/s00262-007-0293-4

M3 - Journal article

C2 - 17285289

VL - 56

SP - 1485

EP - 1499

JO - Cancer Immunology, Immunotherapy

JF - Cancer Immunology, Immunotherapy

SN - 0340-7004

IS - 9

ER -

ID: 8442428