Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial
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Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial. / Trepiakas, Redas; Berntsen, Annika; Hadrup, Sine Reker; Bjørn, Jon; Geertsen, Poul F; Straten, Per Thor; Andersen, Mads H; Pedersen, Anders Elm; Soleimani, Amir; Lorentzen, Torben; Johansen, Julia S; Svane, Inge Marie.
I: Cytotherapy, Bind 12, Nr. 6, 01.10.2010, s. 721-34.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial
AU - Trepiakas, Redas
AU - Berntsen, Annika
AU - Hadrup, Sine Reker
AU - Bjørn, Jon
AU - Geertsen, Poul F
AU - Straten, Per Thor
AU - Andersen, Mads H
AU - Pedersen, Anders Elm
AU - Soleimani, Amir
AU - Lorentzen, Torben
AU - Johansen, Julia S
AU - Svane, Inge Marie
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Dendritic cells are regarded as the most effective antigen presenting cells and coordinators of the immune response and therefore suitable as vaccine basis. Here we present results from a clinical study in which patients with malignant melanoma (MM) with verified progressive disease received vaccination with autologous monocyte-derived mature dendritic cells (DC) pulsed with p53, survivin and telomerase-derived peptides (HLA-A2+ patients) or with autologous/allogeneic tumor lysate (HLA-A2(-) patients) in combination with low-dose interleukin (IL)-2 and interferon (IFN)-alpha2b.
AB - Dendritic cells are regarded as the most effective antigen presenting cells and coordinators of the immune response and therefore suitable as vaccine basis. Here we present results from a clinical study in which patients with malignant melanoma (MM) with verified progressive disease received vaccination with autologous monocyte-derived mature dendritic cells (DC) pulsed with p53, survivin and telomerase-derived peptides (HLA-A2+ patients) or with autologous/allogeneic tumor lysate (HLA-A2(-) patients) in combination with low-dose interleukin (IL)-2 and interferon (IFN)-alpha2b.
U2 - 10.3109/14653241003774045
DO - 10.3109/14653241003774045
M3 - Journal article
C2 - 20429791
VL - 12
SP - 721
EP - 734
JO - Cytotherapy
JF - Cytotherapy
SN - 1465-3249
IS - 6
ER -
ID: 32304621