TY - JOUR

T1 - Usefulness of the myocardial performance index determined by tissue Doppler imaging m-mode for predicting mortality in the general population

AU - Biering-Sørensen, Tor

AU - Møgelvang, Rasmus

AU - Haahr-Pedersen, Sune Ammentorp

AU - Schnohr, Peter

AU - Søgaard, Peter

AU - Jensen, Jan Skov

AU - Biering-Sørensen, Tor

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2011/2/1

Y1 - 2011/2/1

N2 - The objective of this study was to evaluate the prognostic value of the myocardial performance index (MPI), assessed by color-coded tissue Doppler imaging (TDI) M-mode through the anterior mitral leaflet. Color TDI M-mode through the mitral leaflet is an easy, very fast, and precise method to estimate cardiac intervals and thus obtain the MPI, but the diagnostic and prognostic values of this parameter are unknown. In a large population study, cardiac function was evaluated in 1,100 participants by conventional echocardiography and TDI. MPI was calculated from pulse-wave Doppler analyses of left ventricular in- and outflow using standard procedures (MPI(conv)) and by color-coded TDI M-mode through the mitral leaflet in the apical 4-chamber view (MPI(TDI)). MPI(TDI) was increased in subjects with coronary heart disease (CHD) compared to controls, even after multivariable adjustment (p <0.002). During follow-up (median 5.3 years), 90 participants died. MPI(TDI) was significantly associated with overall mortality, and risk of dying increased by 31% per 0.1 increase in MPI(TDI). In contrast to MPI(conv), MPI(TDI) provided independent prognostic information in a multivariable Cox proportional hazard model (adjusting for age, gender, body mass index, heart rate, mean arterial blood pressure, and CHD), with a hazard ratio of 1.18 (p = 0.01) per 0.1 increase in MPI(TDI). In conclusion, MPI(TDI) is a quick, simple, and reproducible measurement, which is increased in subjects with CHD and provides independent prognostic information in a low-risk population

AB - The objective of this study was to evaluate the prognostic value of the myocardial performance index (MPI), assessed by color-coded tissue Doppler imaging (TDI) M-mode through the anterior mitral leaflet. Color TDI M-mode through the mitral leaflet is an easy, very fast, and precise method to estimate cardiac intervals and thus obtain the MPI, but the diagnostic and prognostic values of this parameter are unknown. In a large population study, cardiac function was evaluated in 1,100 participants by conventional echocardiography and TDI. MPI was calculated from pulse-wave Doppler analyses of left ventricular in- and outflow using standard procedures (MPI(conv)) and by color-coded TDI M-mode through the mitral leaflet in the apical 4-chamber view (MPI(TDI)). MPI(TDI) was increased in subjects with coronary heart disease (CHD) compared to controls, even after multivariable adjustment (p <0.002). During follow-up (median 5.3 years), 90 participants died. MPI(TDI) was significantly associated with overall mortality, and risk of dying increased by 31% per 0.1 increase in MPI(TDI). In contrast to MPI(conv), MPI(TDI) provided independent prognostic information in a multivariable Cox proportional hazard model (adjusting for age, gender, body mass index, heart rate, mean arterial blood pressure, and CHD), with a hazard ratio of 1.18 (p = 0.01) per 0.1 increase in MPI(TDI). In conclusion, MPI(TDI) is a quick, simple, and reproducible measurement, which is increased in subjects with CHD and provides independent prognostic information in a low-risk population

U2 - 10.1016/j.amjcard.2010.09.044

DO - 10.1016/j.amjcard.2010.09.044

M3 - Journal article

C2 - 21257018

VL - 107

SP - 478

EP - 483

JO - Am. J. Cardiol.

JF - Am. J. Cardiol.

SN - 0002-9149

IS - 3

ER -