Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients
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Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients. / Broedbaek, K.; Siersma, Volkert Dirk; Henriksen, T.; Weimann, A.; Petersen, M.; Andersen, J.T.; Jimenez-Solem, E.; Stovgaard, E.S.; Hansen, L.J.; Henriksen, J.E.; Bonnema, Steen Joop; Olivarius, Niels de Fine; Poulsen, H.E.
I: Diabetes Care, Bind 34, Nr. 12, 2011, s. 2594-2596.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients
AU - Broedbaek, K.
AU - Siersma, Volkert Dirk
AU - Henriksen, T.
AU - Weimann, A.
AU - Petersen, M.
AU - Andersen, J.T.
AU - Jimenez-Solem, E.
AU - Stovgaard, E.S.
AU - Hansen, L.J.
AU - Henriksen, J.E.
AU - Bonnema, Steen Joop
AU - Olivarius, Niels de Fine
AU - Poulsen, H.E.
N1 - DA - 20111123 IS - 1935-5548 (Electronic) IS - 0149-5992 (Linking) LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't SB - IM
PY - 2011
Y1 - 2011
N2 - OBJECTIVE: We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid oxidation are independent predictors of mortality. RESEARCH DESIGN AND METHODS: We examined the relationship between urinary excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-2'-deoxyguanosine [8-oxodG]) and RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) and long-term mortality using Cox proportional hazards regression. RESULTS: After multivariate adjustment, the hazard ratios for all-cause and diabetes-related mortality of patients with 8-oxoGuo levels in the highest quartile compared with those in the lowest quartile were 1.44 (1.12-1.85) and 1.54 (1.13-2.10), respectively. Conversely, no significant associations between 8-oxodG and mortality were found in the adjusted analyses. CONCLUSIONS: Urinary excretion of the RNA oxidation marker 8-oxoGuo measured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors. This finding suggests that 8-oxoGuo could serve as a new clinical biomarker in diabetes
AB - OBJECTIVE: We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid oxidation are independent predictors of mortality. RESEARCH DESIGN AND METHODS: We examined the relationship between urinary excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-2'-deoxyguanosine [8-oxodG]) and RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) and long-term mortality using Cox proportional hazards regression. RESULTS: After multivariate adjustment, the hazard ratios for all-cause and diabetes-related mortality of patients with 8-oxoGuo levels in the highest quartile compared with those in the lowest quartile were 1.44 (1.12-1.85) and 1.54 (1.13-2.10), respectively. Conversely, no significant associations between 8-oxodG and mortality were found in the adjusted analyses. CONCLUSIONS: Urinary excretion of the RNA oxidation marker 8-oxoGuo measured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors. This finding suggests that 8-oxoGuo could serve as a new clinical biomarker in diabetes
KW - Denmark
KW - diabetes
KW - diagnosis
KW - methods
KW - Mortality
KW - PATIENT
KW - Patients
KW - pharmacology
KW - Research
KW - Research Design
KW - Risk
KW - RISK-FACTORS
KW - Risk Factors
KW - semrap-2011-3
KW - Support
U2 - http://dx.doi.org/10.2337/dc11-1620
DO - http://dx.doi.org/10.2337/dc11-1620
M3 - Journal article
VL - 34
SP - 2594
EP - 2596
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 12
ER -
ID: 37610639