Urinary dysfunction in patients with rectal cancer: a prospective cohort study

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Aim: Urinary dysfunction is one of many complications after treatment for rectal cancer. The aim of this study was to evaluate the prevalence of patient-reported urinary dysfunction at the time of diagnosis and at 1-year follow-up and to assess the risk factors linked to urinary incontinence. Method: Patients with newly diagnosed rectal cancer were included in the QoLiRECT study between 2012 and 2015. Questionnaires from the time of diagnosis and 1-year follow-up were analysed, with 1085 and 916 patients, respectively, eligible for analysis. Regression analyses were made to investigate possible risk factors for incontinence. The patient cohort was also compared with a cohort from the Swedish general population. Results: At baseline, the prevalence of urinary dysfunction (14% of women, 8% of men) was similar to that in the general population. At 1-year follow-up, 20% of patients experienced urinary incontinence (29% of women, 14% of men). Emptying difficulties were experienced by 46% (41% of women, 49% of men) and urgency by 58% across both sexes. Abdominoperineal excision and urinary dysfunction at baseline were found to be independent risk factors for incontinence at 1-year follow-up. Among patients who were continent at baseline, risk factors were female sex, physical inactivity at baseline, comorbidity and abdominoperineal excision. Conclusion: Urinary dysfunction is frequent among patients with rectal cancer, with up to a two-fold increase in symptoms 1 year after diagnosis. Unfortunately, few factors are modifiable and these results stress the importance of informing patients of possible outcomes related to urinary dysfunction after treatment for rectal cancer.

OriginalsprogEngelsk
TidsskriftColorectal Disease
Vol/bind22
Udgave nummer1
Sider (fra-til)18-28
Antal sider11
ISSN1462-8910
DOI
StatusUdgivet - 2020

Bibliografisk note

Funding Information:
Funding: The Swedish Research Council, grant number 2012‐1768 and 2017‐01103; The Swedish Cancer Society CAN 2013/500 and CAN 2016/509; The Swedish Society of Medicine; The Gothenburg Medical Society; The Healthcare Sub‐committee, Region Västra Götaland; ALF grant ALFGBG‐526501, ALFGBG‐136151, ALFGBG‐493341 and ALFGBG‐716581 ‘Agreement concerning research and education of doctors’; Anna‐Lisa and Bror Björnsson Foundation; Assar Gabrielsson Foundation; Mary von Sydow Foundation; Ruth and Richard Julin's Foundation, Lion's Cancer Research Foundation of Western Sweden.

Funding Information:
The authors are grateful for the work performed by the research nurses at the Scandinavian Surgical Outcomes Research Group and by all those involved in the recruitment of patients at participating hospitals: Sahlgrenska University Hospital/?stra; Skaraborg Hospital Sk?vde; NU Hospital Group, Trollh?ttan; Central Hospital of Karlstad; S?dra ?lvsborg Hospital, Bor?s; Karolinska University Hospital; ?rebro University Hospital; Sunderbyn Hospital; V?stmanland's Hospital V?ster?s, Blekinge Hospital, Karlskrona; Mora Hospital; Helsingborg Hospital; Hvidovre Hospital; Slagelse Hospital; Herlev Hospital; and Roskilde Hospital. Funding: The Swedish Research Council, grant number 2012-1768 and 2017-01103; The Swedish Cancer Society CAN 2013/500 and CAN 2016/509; The Swedish Society of Medicine; The Gothenburg Medical Society; The Healthcare Sub-committee, Region V?stra G?taland; ALF grant ALFGBG-526501, ALFGBG-136151, ALFGBG-493341 and ALFGBG-716581 ?Agreement concerning research and education of doctors?; Anna-Lisa and Bror Bj?rnsson Foundation; Assar Gabrielsson Foundation; Mary von Sydow Foundation; Ruth and Richard Julin's Foundation, Lion's Cancer Research Foundation of Western Sweden.

Publisher Copyright:
© 2019 The Authors. Colorectal Disease published by John Wiley & Sons Ltd on behalf of Association of Coloproctology of Great Britain and Ireland.

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