Uncovering a context-specific connectional fingerprint of human dorsal premotor cortex
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Uncovering a context-specific connectional fingerprint of human dorsal premotor cortex. / Moisa, Marius; Siebner, Hartwig R; Pohmann, Rolf; Thielscher, Axel.
I: Journal of Neuroscience, Bind 32, Nr. 21, 23.05.2012, s. 7244-52.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Uncovering a context-specific connectional fingerprint of human dorsal premotor cortex
AU - Moisa, Marius
AU - Siebner, Hartwig R
AU - Pohmann, Rolf
AU - Thielscher, Axel
PY - 2012/5/23
Y1 - 2012/5/23
N2 - Primate electrophysiological and lesion studies indicate a prominent role of the left dorsal premotor cortex (PMd) in action selection based on learned sensorimotor associations. Here we applied transcranial magnetic stimulation (TMS) to human left PMd at low or high intensity while right-handed individuals performed externally paced sequential key presses with their left hand. Movements were cued by abstract visual stimuli, and subjects either freely selected a key press or responded according to a prelearned visuomotor mapping rule. Continuous arterial spin labeling was interleaved with TMS to directly assess how stimulation of left PMd modulates task-related brain activity depending on the mode of movement selection. Relative to passive viewing, both tasks activated a frontoparietal motor network. Compared with low-intensity TMS, high-intensity TMS of left PMd was associated with an increase in activity in medial and right premotor areas without affecting task performance. Critically, this increase in task-related activity was only present when movement selection relied on arbitrary visuomotor associations but not during freely selected movements. Psychophysiological interaction analysis revealed a context-specific increase in functional coupling between the stimulated left PMd and remote right-hemispheric and mesial motor regions that was only present during arbitrary visuomotor mapping. Our TMS perturbation approach yielded causal evidence that the left PMd is implicated in mapping external cues onto the appropriate movement in humans. Furthermore, the data suggest that the left PMd may transiently form a functional network together with right-hemispheric and mesial motor regions to sustain visuomotor mapping performed with the left nondominant hand.
AB - Primate electrophysiological and lesion studies indicate a prominent role of the left dorsal premotor cortex (PMd) in action selection based on learned sensorimotor associations. Here we applied transcranial magnetic stimulation (TMS) to human left PMd at low or high intensity while right-handed individuals performed externally paced sequential key presses with their left hand. Movements were cued by abstract visual stimuli, and subjects either freely selected a key press or responded according to a prelearned visuomotor mapping rule. Continuous arterial spin labeling was interleaved with TMS to directly assess how stimulation of left PMd modulates task-related brain activity depending on the mode of movement selection. Relative to passive viewing, both tasks activated a frontoparietal motor network. Compared with low-intensity TMS, high-intensity TMS of left PMd was associated with an increase in activity in medial and right premotor areas without affecting task performance. Critically, this increase in task-related activity was only present when movement selection relied on arbitrary visuomotor associations but not during freely selected movements. Psychophysiological interaction analysis revealed a context-specific increase in functional coupling between the stimulated left PMd and remote right-hemispheric and mesial motor regions that was only present during arbitrary visuomotor mapping. Our TMS perturbation approach yielded causal evidence that the left PMd is implicated in mapping external cues onto the appropriate movement in humans. Furthermore, the data suggest that the left PMd may transiently form a functional network together with right-hemispheric and mesial motor regions to sustain visuomotor mapping performed with the left nondominant hand.
KW - Adult
KW - Brain Mapping
KW - Cues
KW - Female
KW - Frontal Lobe
KW - Functional Laterality
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Motor Cortex
KW - Neural Pathways
KW - Parietal Lobe
KW - Psychomotor Performance
KW - Spin Labels
KW - Transcranial Magnetic Stimulation
U2 - 10.1523/JNEUROSCI.2757-11.2012
DO - 10.1523/JNEUROSCI.2757-11.2012
M3 - Journal article
C2 - 22623669
VL - 32
SP - 7244
EP - 7252
JO - The Journal of neuroscience : the official journal of the Society for Neuroscience
JF - The Journal of neuroscience : the official journal of the Society for Neuroscience
SN - 0270-6474
IS - 21
ER -
ID: 48874779