Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis
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Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis. / Mogensen, Mette; Bojesen, Sophie; Israelsen, Niels M; Maria, Michael; Jensen, Mikkel; Podoleanu, Adrian; Bang, Ole; Hædersdal, Merete.
I: Journal of Biophotonics, Bind 11, Nr. 9, e201700348, 2018, s. 1-10.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis
AU - Mogensen, Mette
AU - Bojesen, Sophie
AU - Israelsen, Niels M
AU - Maria, Michael
AU - Jensen, Mikkel
AU - Podoleanu, Adrian
AU - Bang, Ole
AU - Hædersdal, Merete
PY - 2018
Y1 - 2018
N2 - Optical coherence tomography (OCT) is an established imaging technology for in vivo skin investigation. Topical application of gold nanoshells (GNS) provides contrast enhancement in OCT by generating a strong hyperreflective signal from hair follicles and sweat glands, which are the natural skin openings. This study explores the utility of 150 nm diameter GNS as contrast agent for OCT imaging. GNS was massaged into skin and examined in four skin areas of 11 healthy volunteers. A commercial OCT system and a prototype with 3 μm resolution (UHR-OCT) were employed to detect potential benefits of increased resolution and variability in intensity generated by the GNS. In both OCT-systems GNS enhanced contrast from hair follicles and sweat ducts. Highest average penetration depth of GNS was in armpit 0.64 mm ± SD 0.17, maximum penetration depth was 1.20 mm in hair follicles and 15 to 40 μm in sweat ducts. Pixel intensity generated from GNS in hair follicles was significantly higher in UHR-OCT images (P = .002) and epidermal thickness significantly lower 0.14 vs 0.16 mm (P = .027). This study suggests that GNSs are interesting candidates for increasing sensitivity in OCT diagnosis of hair and sweat gland disorders and demonstrates that choice of OCT systems influences results.
AB - Optical coherence tomography (OCT) is an established imaging technology for in vivo skin investigation. Topical application of gold nanoshells (GNS) provides contrast enhancement in OCT by generating a strong hyperreflective signal from hair follicles and sweat glands, which are the natural skin openings. This study explores the utility of 150 nm diameter GNS as contrast agent for OCT imaging. GNS was massaged into skin and examined in four skin areas of 11 healthy volunteers. A commercial OCT system and a prototype with 3 μm resolution (UHR-OCT) were employed to detect potential benefits of increased resolution and variability in intensity generated by the GNS. In both OCT-systems GNS enhanced contrast from hair follicles and sweat ducts. Highest average penetration depth of GNS was in armpit 0.64 mm ± SD 0.17, maximum penetration depth was 1.20 mm in hair follicles and 15 to 40 μm in sweat ducts. Pixel intensity generated from GNS in hair follicles was significantly higher in UHR-OCT images (P = .002) and epidermal thickness significantly lower 0.14 vs 0.16 mm (P = .027). This study suggests that GNSs are interesting candidates for increasing sensitivity in OCT diagnosis of hair and sweat gland disorders and demonstrates that choice of OCT systems influences results.
U2 - 10.1002/jbio.201700348
DO - 10.1002/jbio.201700348
M3 - Journal article
C2 - 29611306
VL - 11
SP - 1
EP - 10
JO - Journal of Biophotonics
JF - Journal of Biophotonics
SN - 1864-063X
IS - 9
M1 - e201700348
ER -
ID: 215925242