Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis

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Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis. / Mogensen, Mette; Bojesen, Sophie; Israelsen, Niels M; Maria, Michael; Jensen, Mikkel; Podoleanu, Adrian; Bang, Ole; Hædersdal, Merete.

I: Journal of Biophotonics, Bind 11, Nr. 9, e201700348, 2018, s. 1-10.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Mogensen, M, Bojesen, S, Israelsen, NM, Maria, M, Jensen, M, Podoleanu, A, Bang, O & Hædersdal, M 2018, 'Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis', Journal of Biophotonics, bind 11, nr. 9, e201700348, s. 1-10. https://doi.org/10.1002/jbio.201700348

APA

Mogensen, M., Bojesen, S., Israelsen, N. M., Maria, M., Jensen, M., Podoleanu, A., Bang, O., & Hædersdal, M. (2018). Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis. Journal of Biophotonics, 11(9), 1-10. [e201700348]. https://doi.org/10.1002/jbio.201700348

Vancouver

Mogensen M, Bojesen S, Israelsen NM, Maria M, Jensen M, Podoleanu A o.a. Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis. Journal of Biophotonics. 2018;11(9):1-10. e201700348. https://doi.org/10.1002/jbio.201700348

Author

Mogensen, Mette ; Bojesen, Sophie ; Israelsen, Niels M ; Maria, Michael ; Jensen, Mikkel ; Podoleanu, Adrian ; Bang, Ole ; Hædersdal, Merete. / Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis. I: Journal of Biophotonics. 2018 ; Bind 11, Nr. 9. s. 1-10.

Bibtex

@article{ccd81c6bfc1841359593354648f5322e,
title = "Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis",
abstract = "Optical coherence tomography (OCT) is an established imaging technology for in vivo skin investigation. Topical application of gold nanoshells (GNS) provides contrast enhancement in OCT by generating a strong hyperreflective signal from hair follicles and sweat glands, which are the natural skin openings. This study explores the utility of 150 nm diameter GNS as contrast agent for OCT imaging. GNS was massaged into skin and examined in four skin areas of 11 healthy volunteers. A commercial OCT system and a prototype with 3 μm resolution (UHR-OCT) were employed to detect potential benefits of increased resolution and variability in intensity generated by the GNS. In both OCT-systems GNS enhanced contrast from hair follicles and sweat ducts. Highest average penetration depth of GNS was in armpit 0.64 mm ± SD 0.17, maximum penetration depth was 1.20 mm in hair follicles and 15 to 40 μm in sweat ducts. Pixel intensity generated from GNS in hair follicles was significantly higher in UHR-OCT images (P = .002) and epidermal thickness significantly lower 0.14 vs 0.16 mm (P = .027). This study suggests that GNSs are interesting candidates for increasing sensitivity in OCT diagnosis of hair and sweat gland disorders and demonstrates that choice of OCT systems influences results.",
author = "Mette Mogensen and Sophie Bojesen and Israelsen, {Niels M} and Michael Maria and Mikkel Jensen and Adrian Podoleanu and Ole Bang and Merete H{\ae}dersdal",
year = "2018",
doi = "10.1002/jbio.201700348",
language = "English",
volume = "11",
pages = "1--10",
journal = "Journal of Biophotonics",
issn = "1864-063X",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "9",

}

RIS

TY - JOUR

T1 - Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis

AU - Mogensen, Mette

AU - Bojesen, Sophie

AU - Israelsen, Niels M

AU - Maria, Michael

AU - Jensen, Mikkel

AU - Podoleanu, Adrian

AU - Bang, Ole

AU - Hædersdal, Merete

PY - 2018

Y1 - 2018

N2 - Optical coherence tomography (OCT) is an established imaging technology for in vivo skin investigation. Topical application of gold nanoshells (GNS) provides contrast enhancement in OCT by generating a strong hyperreflective signal from hair follicles and sweat glands, which are the natural skin openings. This study explores the utility of 150 nm diameter GNS as contrast agent for OCT imaging. GNS was massaged into skin and examined in four skin areas of 11 healthy volunteers. A commercial OCT system and a prototype with 3 μm resolution (UHR-OCT) were employed to detect potential benefits of increased resolution and variability in intensity generated by the GNS. In both OCT-systems GNS enhanced contrast from hair follicles and sweat ducts. Highest average penetration depth of GNS was in armpit 0.64 mm ± SD 0.17, maximum penetration depth was 1.20 mm in hair follicles and 15 to 40 μm in sweat ducts. Pixel intensity generated from GNS in hair follicles was significantly higher in UHR-OCT images (P = .002) and epidermal thickness significantly lower 0.14 vs 0.16 mm (P = .027). This study suggests that GNSs are interesting candidates for increasing sensitivity in OCT diagnosis of hair and sweat gland disorders and demonstrates that choice of OCT systems influences results.

AB - Optical coherence tomography (OCT) is an established imaging technology for in vivo skin investigation. Topical application of gold nanoshells (GNS) provides contrast enhancement in OCT by generating a strong hyperreflective signal from hair follicles and sweat glands, which are the natural skin openings. This study explores the utility of 150 nm diameter GNS as contrast agent for OCT imaging. GNS was massaged into skin and examined in four skin areas of 11 healthy volunteers. A commercial OCT system and a prototype with 3 μm resolution (UHR-OCT) were employed to detect potential benefits of increased resolution and variability in intensity generated by the GNS. In both OCT-systems GNS enhanced contrast from hair follicles and sweat ducts. Highest average penetration depth of GNS was in armpit 0.64 mm ± SD 0.17, maximum penetration depth was 1.20 mm in hair follicles and 15 to 40 μm in sweat ducts. Pixel intensity generated from GNS in hair follicles was significantly higher in UHR-OCT images (P = .002) and epidermal thickness significantly lower 0.14 vs 0.16 mm (P = .027). This study suggests that GNSs are interesting candidates for increasing sensitivity in OCT diagnosis of hair and sweat gland disorders and demonstrates that choice of OCT systems influences results.

U2 - 10.1002/jbio.201700348

DO - 10.1002/jbio.201700348

M3 - Journal article

C2 - 29611306

VL - 11

SP - 1

EP - 10

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 9

M1 - e201700348

ER -

ID: 215925242