Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Erik G Jönsson
  • Kristina Larsson
  • Maria Vares
  • Thomas Hansen
  • Wang, August Gabriel
  • Srdjan Djurovic
  • Kjersti S Rønningen
  • Ole A Andreassen
  • Ingrid Agartz
  • Werge, Thomas
  • Lars Terenius
  • Håkan Hall
Recent meta-analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two of its functional single gene polymorphisms (SNPs; C677T and A1298C) and schizophrenia. Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. In a replication attempt the MTHFR C677T and A1298C SNPs were analyzed in three Scandinavian schizophrenia case-control samples. In addition, Norwegian patients with bipolar disorder were investigated. There were no statistically significant allele or genotype case-control differences. The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder. However, when combined with previous studies in meta-analyses there is still evidence for association between the MTHFR C677T polymorphism and schizophrenia. Additional studies are warranted to shed further light on these relationships.
OriginalsprogEngelsk
TidsskriftAmerican Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Vol/bind147B
Udgave nummer6
Sider (fra-til)976-82
Antal sider7
ISSN1552-4841
DOI
StatusUdgivet - 2008

ID: 48607530