Two- and 6-minute walk tests assess walking capability equally in neuromuscular diseases
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Two- and 6-minute walk tests assess walking capability equally in neuromuscular diseases. / Andersen, Linda Kahr; Knak, Kirsten Lykke; Witting, Nanna; Vissing, John.
I: Neurology, Bind 86, Nr. 5, 02.02.2016, s. 442-5.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Two- and 6-minute walk tests assess walking capability equally in neuromuscular diseases
AU - Andersen, Linda Kahr
AU - Knak, Kirsten Lykke
AU - Witting, Nanna
AU - Vissing, John
N1 - © 2016 American Academy of Neurology.
PY - 2016/2/2
Y1 - 2016/2/2
N2 - OBJECTIVE: This methodologic study investigates if the 2-minute walk test (2MWT) can be a valid alternative to the 6-minute walk test (6MWT) to describe walking capability in patients with neuromuscular diseases.METHODS: Patients (n = 115) with different neuromuscular diseases were invited to participate on 2 test days, each consisting of 1 2MWT and 1 6MWT separated by a minimum 30-minute period of rest. The order of the walk tests was randomly assigned via sealed envelopes. A group of 38 healthy controls completed 1 6MWT.RESULTS: The mean walking distance for the 2MWT was 142.8 meters and for the 6MWT 405.3 meters. The distance walked in the 2MWT was highly correlated to the distance walked in the 6MWT (r = 0.99, p < 0.001). There was a significant decrease in walking speed from the first to last minute in the 6MWT, both among patients and healthy controls, which was not evident in the 2MWT. Results were consistent across diagnoses and levels of disease severity.CONCLUSION: The 2MWT is a potential alternative to the 6MWT to describe walking capability among patients with neuromuscular diseases during clinical trials.
AB - OBJECTIVE: This methodologic study investigates if the 2-minute walk test (2MWT) can be a valid alternative to the 6-minute walk test (6MWT) to describe walking capability in patients with neuromuscular diseases.METHODS: Patients (n = 115) with different neuromuscular diseases were invited to participate on 2 test days, each consisting of 1 2MWT and 1 6MWT separated by a minimum 30-minute period of rest. The order of the walk tests was randomly assigned via sealed envelopes. A group of 38 healthy controls completed 1 6MWT.RESULTS: The mean walking distance for the 2MWT was 142.8 meters and for the 6MWT 405.3 meters. The distance walked in the 2MWT was highly correlated to the distance walked in the 6MWT (r = 0.99, p < 0.001). There was a significant decrease in walking speed from the first to last minute in the 6MWT, both among patients and healthy controls, which was not evident in the 2MWT. Results were consistent across diagnoses and levels of disease severity.CONCLUSION: The 2MWT is a potential alternative to the 6MWT to describe walking capability among patients with neuromuscular diseases during clinical trials.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Exercise Test
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Muscle Strength
KW - Muscle Weakness
KW - Neuromuscular Diseases
KW - Time Factors
KW - Walking
KW - Young Adult
KW - Journal Article
U2 - 10.1212/WNL.0000000000002332
DO - 10.1212/WNL.0000000000002332
M3 - Journal article
C2 - 26740680
VL - 86
SP - 442
EP - 445
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 5
ER -
ID: 177097343