Transperitoneal transport of sodium during hypertonic peritoneal dialysis
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Transperitoneal transport of sodium during hypertonic peritoneal dialysis. / Graff, J; Fugleberg, S; Brahm, J; Fogh-Andersen, N.
I: Clinical physiology (Oxford, England), Bind 16, Nr. 1, 01.1996, s. 31-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Transperitoneal transport of sodium during hypertonic peritoneal dialysis
AU - Graff, J
AU - Fugleberg, S
AU - Brahm, J
AU - Fogh-Andersen, N
PY - 1996/1
Y1 - 1996/1
N2 - The mechanisms of transperitoneal sodium transport during hypertonic peritoneal dialysis were evaluated by kinetic modelling. A total of six nested mathematical models were designed to elucidate the presence or absence of diffusive, non-lymphatic convective and lymphatic convective solute transport. Experimental results were obtained from 26 non-diabetic patients undergoing peritoneal dialysis. The model validation procedure demonstrated that only diffusive and non-lymphatic convective transport mechanisms were identifiable in the transperitoneal transport of sodium. Non-lymphatic convective sodium transport was the most important quantitative transport mechanism during the first 90 min of the dwell. Significant sodium sieving was demonstrated and explains the observation of hypernatremia in dialysis with hypertonic dialysis fluid.
AB - The mechanisms of transperitoneal sodium transport during hypertonic peritoneal dialysis were evaluated by kinetic modelling. A total of six nested mathematical models were designed to elucidate the presence or absence of diffusive, non-lymphatic convective and lymphatic convective solute transport. Experimental results were obtained from 26 non-diabetic patients undergoing peritoneal dialysis. The model validation procedure demonstrated that only diffusive and non-lymphatic convective transport mechanisms were identifiable in the transperitoneal transport of sodium. Non-lymphatic convective sodium transport was the most important quantitative transport mechanism during the first 90 min of the dwell. Significant sodium sieving was demonstrated and explains the observation of hypernatremia in dialysis with hypertonic dialysis fluid.
KW - Adult
KW - Aged
KW - Biological Transport
KW - Dialysis Solutions
KW - Female
KW - Humans
KW - Hypertonic Solutions
KW - Kinetics
KW - Male
KW - Middle Aged
KW - Models, Biological
KW - Peritoneal Dialysis
KW - Peritoneum
KW - Sodium
M3 - Journal article
C2 - 8867775
VL - 16
SP - 31
EP - 39
JO - Clinical Physiology
JF - Clinical Physiology
SN - 0144-5979
IS - 1
ER -
ID: 94518195