Transfer of bromocriptine across the blood-brain barrier in man
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The transfer of 14C-bromocriptine across the blood-brain barrier was studied in 10 patients using the double indicator single injection method. The extraction (E) of bromocriptine was 8 % (quartiles: 6 and 14 %). Based on the results the cerebral uptake velocity of bromocriptine was calculated assuming constant arterial drug concentration. Its T 1/2 was found to be 12--24 minutes, depending on the tissue-blood partition coefficient.
Originalsprog | Engelsk |
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Bogserie | Acta Neurologica Scandinavica |
Vol/bind | 59 |
Udgave nummer | 2-3 |
Sider (fra-til) | 88-95 |
Antal sider | 8 |
ISSN | 0001-6314 |
DOI | |
Status | Udgivet - mar. 1979 |
ID: 275605354