Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation.
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Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation. / Durkin, M E; Loechel, F; Mattei, M G; Gilpin, B J; Albrechtsen, R; Wewer, U M.
I: FEBS Letters, Bind 411, Nr. 2-3, 1997, s. 296-300.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation.
AU - Durkin, M E
AU - Loechel, F
AU - Mattei, M G
AU - Gilpin, B J
AU - Albrechtsen, R
AU - Wewer, U M
N1 - Keywords: Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 20; Cloning, Molecular; Gene Expression Regulation; Humans; In Situ Hybridization; Laminin; Linkage (Genetics); Mice; Molecular Sequence Data; Mutation; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid
PY - 1997
Y1 - 1997
N2 - To investigate the function of the laminin alpha5-chain, previously identified in mice, cDNA clones encoding the 953-amino-acid carboxy terminal G-domain of the human laminin alpha5-chain were characterized. Northern blot analysis showed that the laminin alpha5-chain is expressed in human placenta, heart, lung, skeletal muscle, kidney, and pancreas. The human laminin alpha5-chain gene (LAMA5) was assigned to chromosome 20q13.2-q13.3 by in situ hybridization, and the mouse gene (Lama5) was mapped by linkage analysis to a syntonic region of distal chromosome 2, close to the locus for the ragged (Ra) mutation.
AB - To investigate the function of the laminin alpha5-chain, previously identified in mice, cDNA clones encoding the 953-amino-acid carboxy terminal G-domain of the human laminin alpha5-chain were characterized. Northern blot analysis showed that the laminin alpha5-chain is expressed in human placenta, heart, lung, skeletal muscle, kidney, and pancreas. The human laminin alpha5-chain gene (LAMA5) was assigned to chromosome 20q13.2-q13.3 by in situ hybridization, and the mouse gene (Lama5) was mapped by linkage analysis to a syntonic region of distal chromosome 2, close to the locus for the ragged (Ra) mutation.
M3 - Journal article
C2 - 9271224
VL - 411
SP - 296
EP - 300
JO - F E B S Letters
JF - F E B S Letters
SN - 0014-5793
IS - 2-3
ER -
ID: 5236642