Tissue Doppler echocardiography reveals distinct patterns of impaired myocardial velocities in different degrees of coronary artery disease
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Tissue Doppler echocardiography reveals distinct patterns of impaired myocardial velocities in different degrees of coronary artery disease. / Hoffmann, Soren; Mogelvang, Rasmus; Olsen, Niels Thue; Søgaard, Peter; Fritz-Hansen, Thomas; Bech, Jan; Galatius, Soren; Madsen, Jan Kyst; Jensen, Jan Skov.
I: European Journal of Echocardiography, Bind 11, Nr. 6, 01.07.2010, s. 544-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Tissue Doppler echocardiography reveals distinct patterns of impaired myocardial velocities in different degrees of coronary artery disease
AU - Hoffmann, Soren
AU - Mogelvang, Rasmus
AU - Olsen, Niels Thue
AU - Søgaard, Peter
AU - Fritz-Hansen, Thomas
AU - Bech, Jan
AU - Galatius, Soren
AU - Madsen, Jan Kyst
AU - Jensen, Jan Skov
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Aim To determine how the left ventricular wall motion assessed by echocardiographic Tissue Doppler Imaging (TDI) is affected by increasing severity of coronary artery disease (CAD) among patients with stable angina pectoris and preserved ejection fraction. METHODS AND RESULTS: This study comprises 82 patients with suspected angina pectoris, no previous cardiac history, and a normal ejection fraction, who were all examined with colour TDI prior to coronary angiography. Patients without significant stenoses (n = 35) constituted the control group and patients with significant stenoses (n = 47) were divided into three groups according to significant one-, two-, or three-vessel disease (n = 18, n = 14, and n = 15, respectively). Regional longitudinal peak systolic (s'), early (e'), and late diastolic (a') myocardial velocities were measured at six mitral annular sites and averaged to provide global estimates. Each patient with significant coronary disease was matched with a control of the same age, sex, body mass index, and status regarding diabetes and hypertension. Global systolic and diastolic performance by TDI (in terms of global s' and E/e') were negatively correlated to the number of vessels with significant stenoses (both P <0.05). Regional analyses revealed that in one- and two-vessel disease, e' decreased significantly in the segments supplied by a stenotic artery. In patients with one-vessel disease, a' increased compensatorily with a significant reduction of e'/a'-ratio (0.86 +/- 0.24 vs. 1.00 +/- 0.28, P <0.05). Both regional and global s' was significantly reduced in patients with three-vessels disease. CONCLUSION: Colour TDI performed at rest in patients with stable angina and preserved ejection fraction reveals both diastolic and systolic dysfunction and the nature of the dysfunction depends on the extent of the CAD.
AB - Aim To determine how the left ventricular wall motion assessed by echocardiographic Tissue Doppler Imaging (TDI) is affected by increasing severity of coronary artery disease (CAD) among patients with stable angina pectoris and preserved ejection fraction. METHODS AND RESULTS: This study comprises 82 patients with suspected angina pectoris, no previous cardiac history, and a normal ejection fraction, who were all examined with colour TDI prior to coronary angiography. Patients without significant stenoses (n = 35) constituted the control group and patients with significant stenoses (n = 47) were divided into three groups according to significant one-, two-, or three-vessel disease (n = 18, n = 14, and n = 15, respectively). Regional longitudinal peak systolic (s'), early (e'), and late diastolic (a') myocardial velocities were measured at six mitral annular sites and averaged to provide global estimates. Each patient with significant coronary disease was matched with a control of the same age, sex, body mass index, and status regarding diabetes and hypertension. Global systolic and diastolic performance by TDI (in terms of global s' and E/e') were negatively correlated to the number of vessels with significant stenoses (both P <0.05). Regional analyses revealed that in one- and two-vessel disease, e' decreased significantly in the segments supplied by a stenotic artery. In patients with one-vessel disease, a' increased compensatorily with a significant reduction of e'/a'-ratio (0.86 +/- 0.24 vs. 1.00 +/- 0.28, P <0.05). Both regional and global s' was significantly reduced in patients with three-vessels disease. CONCLUSION: Colour TDI performed at rest in patients with stable angina and preserved ejection fraction reveals both diastolic and systolic dysfunction and the nature of the dysfunction depends on the extent of the CAD.
U2 - http://dx.doi.org/10.1093/ejechocard/jeq015
DO - http://dx.doi.org/10.1093/ejechocard/jeq015
M3 - Journal article
VL - 11
SP - 544
EP - 549
JO - European Heart Journal Cardiovascular Imaging
JF - European Heart Journal Cardiovascular Imaging
SN - 2047-2404
IS - 6
ER -
ID: 34049841