TY - JOUR

T1 - Thrombelastography and Conventional Coagulation Markers in Chronic Obstructive Pulmonary Disease

T2 - A Prospective Paired-Measurements Study Comparing Exacerbation and Stable Phases

AU - Rastoder, Ema

AU - Kamstrup, Peter

AU - Hedsund, Caroline

AU - Jordan, Alexander

AU - Sivapalan, Pradeesh

AU - Rømer, Valdemar

AU - Falkvist, Frederikke

AU - Hamidi, Sadaf

AU - Bendstrup, Elisabeth

AU - Sperling, Søren

AU - Dons, Maria

AU - Biering-Sørensen, Tor

AU - Falster, Casper

AU - Laursen, Christian B

AU - Carlsen, Jørn

AU - Jensen, Jens-Ulrik Stæhr

PY - 2024

Y1 - 2024

N2 - Chronic Obstructive Pulmonary Disease (COPD) exacerbation is known for its substantial impact on morbidity and mortality among affected patients, creating a significant healthcare burden worldwide. Coagulation abnormalities have emerged as potential contributors to exacerbation pathogenesis, raising concerns about increased thrombotic events during exacerbation. The aim of this study was to explore the differences in thrombelastography (TEG) parameters and coagulation markers in COPD patients during admission with exacerbation and at a follow-up after discharge. This was a multi-center cohort study. COPD patients were enrolled within 72 h of hospitalization. The baseline assessments were Kaolin-TEG and blood samples. Statistical analysis involved using descriptive statistics; the main analysis was a paired t-test comparing coagulation parameters between exacerbation and follow-up. One hundred patients participated, 66% of whom were female, with a median age of 78.5 years and comorbidities including atrial fibrillation (18%) and essential arterial hypertension (45%), and sixty-five individuals completed a follow-up after discharge. No significant variations were observed in Kaolin-TEG or conventional coagulation markers between exacerbation and follow-up. The Activated Partial Thromboplastin Clotting Time (APTT) results were near-significant, with p = 0.08. In conclusion, TEG parameters displayed no significant alterations between exacerbation and follow-up.

AB - Chronic Obstructive Pulmonary Disease (COPD) exacerbation is known for its substantial impact on morbidity and mortality among affected patients, creating a significant healthcare burden worldwide. Coagulation abnormalities have emerged as potential contributors to exacerbation pathogenesis, raising concerns about increased thrombotic events during exacerbation. The aim of this study was to explore the differences in thrombelastography (TEG) parameters and coagulation markers in COPD patients during admission with exacerbation and at a follow-up after discharge. This was a multi-center cohort study. COPD patients were enrolled within 72 h of hospitalization. The baseline assessments were Kaolin-TEG and blood samples. Statistical analysis involved using descriptive statistics; the main analysis was a paired t-test comparing coagulation parameters between exacerbation and follow-up. One hundred patients participated, 66% of whom were female, with a median age of 78.5 years and comorbidities including atrial fibrillation (18%) and essential arterial hypertension (45%), and sixty-five individuals completed a follow-up after discharge. No significant variations were observed in Kaolin-TEG or conventional coagulation markers between exacerbation and follow-up. The Activated Partial Thromboplastin Clotting Time (APTT) results were near-significant, with p = 0.08. In conclusion, TEG parameters displayed no significant alterations between exacerbation and follow-up.

KW - Humans

KW - Female

KW - Aged

KW - Male

KW - Thrombelastography/methods

KW - Cohort Studies

KW - Prospective Studies

KW - Kaolin

KW - Pulmonary Disease, Chronic Obstructive

U2 - 10.3390/ijms25042051

DO - 10.3390/ijms25042051

M3 - Journal article

C2 - 38396728

VL - 25

JO - International Journal of Molecular Sciences (CD-ROM)

JF - International Journal of Molecular Sciences (CD-ROM)

SN - 1424-6783

IS - 4

M1 - 2051

ER -